| Full name: dynein axonemal heavy chain 5 | Alias Symbol: Dnahc5|HL1|PCD|CILD3|KTGNR | ||
| Type: protein-coding gene | Cytoband: 5p15.2 | ||
| Entrez ID: 1767 | HGNC ID: HGNC:2950 | Ensembl Gene: ENSG00000039139 | OMIM ID: 603335 |
| Drug and gene relationship at DGIdb | |||
Expression of DNAH5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNAH5 | 1767 | 232381_s_at | 0.5946 | 0.2893 | |
| GSE26886 | DNAH5 | 1767 | 232381_s_at | 0.9640 | 0.0019 | |
| GSE45670 | DNAH5 | 1767 | 232381_s_at | 0.2236 | 0.3473 | |
| GSE53622 | DNAH5 | 1767 | 77949 | 1.0542 | 0.0001 | |
| GSE53624 | DNAH5 | 1767 | 77949 | 1.2858 | 0.0000 | |
| GSE63941 | DNAH5 | 1767 | 232381_s_at | -1.2845 | 0.0154 | |
| GSE77861 | DNAH5 | 1767 | 232381_s_at | -0.0208 | 0.8916 | |
| TCGA | DNAH5 | 1767 | RNAseq | -0.1185 | 0.7553 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by DNAH5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNAH5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNAH5 | 1767 | 12 | 0 | 18 | |
| GSE20123 | DNAH5 | 1767 | 12 | 0 | 18 | |
| GSE43470 | DNAH5 | 1767 | 18 | 0 | 25 | |
| GSE46452 | DNAH5 | 1767 | 6 | 22 | 31 | |
| GSE47630 | DNAH5 | 1767 | 6 | 11 | 23 | |
| GSE54993 | DNAH5 | 1767 | 5 | 5 | 60 | |
| GSE54994 | DNAH5 | 1767 | 29 | 1 | 23 | |
| GSE60625 | DNAH5 | 1767 | 0 | 0 | 11 | |
| GSE74703 | DNAH5 | 1767 | 14 | 0 | 22 | |
| GSE74704 | DNAH5 | 1767 | 11 | 0 | 9 | |
| TCGA | DNAH5 | 1767 | 59 | 3 | 34 |
Total number of gains: 172; Total number of losses: 42; Total Number of normals: 274.
Somatic mutations of DNAH5:
Generating mutation plots.
Highly correlated genes for DNAH5:
Showing top 20/38 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNAH5 | ADAMTS3 | 0.664621 | 3 | 0 | 3 |
| DNAH5 | PGM2L1 | 0.619987 | 3 | 0 | 3 |
| DNAH5 | CLN5 | 0.619877 | 3 | 0 | 3 |
| DNAH5 | SLC22A4 | 0.609949 | 4 | 0 | 3 |
| DNAH5 | ADD1 | 0.6088 | 3 | 0 | 3 |
| DNAH5 | GRK4 | 0.585151 | 4 | 0 | 3 |
| DNAH5 | DNER | 0.584491 | 4 | 0 | 3 |
| DNAH5 | TRABD2A | 0.580947 | 3 | 0 | 3 |
| DNAH5 | GALNT6 | 0.575594 | 5 | 0 | 3 |
| DNAH5 | LRPAP1 | 0.572927 | 4 | 0 | 4 |
| DNAH5 | GPR68 | 0.570851 | 6 | 0 | 3 |
| DNAH5 | GLIS2 | 0.570101 | 3 | 0 | 3 |
| DNAH5 | AP5S1 | 0.569749 | 3 | 0 | 3 |
| DNAH5 | VDR | 0.564129 | 3 | 0 | 3 |
| DNAH5 | PIGG | 0.562961 | 4 | 0 | 3 |
| DNAH5 | HOMER3 | 0.558635 | 5 | 0 | 3 |
| DNAH5 | PMEPA1 | 0.558171 | 5 | 0 | 3 |
| DNAH5 | NOSIP | 0.555289 | 3 | 0 | 3 |
| DNAH5 | MFSD10 | 0.555024 | 5 | 0 | 3 |
| DNAH5 | TGFBI | 0.550088 | 6 | 0 | 3 |
For details and further investigation, click here
