| Full name: glypican 1 | Alias Symbol: glypican | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 2817 | HGNC ID: HGNC:4449 | Ensembl Gene: ENSG00000063660 | OMIM ID: 600395 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
GPC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of GPC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPC1 | 2817 | 202756_s_at | 0.7834 | 0.3089 | |
| GSE20347 | GPC1 | 2817 | 202756_s_at | 0.4026 | 0.0585 | |
| GSE23400 | GPC1 | 2817 | 202756_s_at | 0.4860 | 0.0003 | |
| GSE26886 | GPC1 | 2817 | 202756_s_at | 0.6639 | 0.0018 | |
| GSE29001 | GPC1 | 2817 | 202756_s_at | 0.3624 | 0.5323 | |
| GSE38129 | GPC1 | 2817 | 202756_s_at | 0.7607 | 0.0005 | |
| GSE45670 | GPC1 | 2817 | 202756_s_at | 0.7745 | 0.0061 | |
| GSE53622 | GPC1 | 2817 | 11760 | 0.8776 | 0.0000 | |
| GSE53624 | GPC1 | 2817 | 11760 | 0.8541 | 0.0000 | |
| GSE63941 | GPC1 | 2817 | 202756_s_at | -0.1678 | 0.8293 | |
| GSE77861 | GPC1 | 2817 | 202756_s_at | 1.2103 | 0.0010 | |
| GSE97050 | GPC1 | 2817 | A_23_P209904 | 0.3752 | 0.2530 | |
| SRP007169 | GPC1 | 2817 | RNAseq | 1.2929 | 0.0003 | |
| SRP008496 | GPC1 | 2817 | RNAseq | 1.1993 | 0.0000 | |
| SRP064894 | GPC1 | 2817 | RNAseq | 0.2081 | 0.4625 | |
| SRP133303 | GPC1 | 2817 | RNAseq | 1.0621 | 0.0005 | |
| SRP159526 | GPC1 | 2817 | RNAseq | 1.1035 | 0.0110 | |
| SRP193095 | GPC1 | 2817 | RNAseq | 1.0799 | 0.0003 | |
| SRP219564 | GPC1 | 2817 | RNAseq | 0.0413 | 0.9400 | |
| TCGA | GPC1 | 2817 | RNAseq | 0.5388 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by GPC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPC1 | 2817 | 1 | 12 | 17 | |
| GSE20123 | GPC1 | 2817 | 1 | 12 | 17 | |
| GSE43470 | GPC1 | 2817 | 1 | 9 | 33 | |
| GSE46452 | GPC1 | 2817 | 0 | 5 | 54 | |
| GSE47630 | GPC1 | 2817 | 4 | 5 | 31 | |
| GSE54993 | GPC1 | 2817 | 3 | 3 | 64 | |
| GSE54994 | GPC1 | 2817 | 8 | 9 | 36 | |
| GSE60625 | GPC1 | 2817 | 0 | 3 | 8 | |
| GSE74703 | GPC1 | 2817 | 1 | 7 | 28 | |
| GSE74704 | GPC1 | 2817 | 1 | 5 | 14 | |
| TCGA | GPC1 | 2817 | 11 | 29 | 56 |
Total number of gains: 31; Total number of losses: 99; Total Number of normals: 358.
Somatic mutations of GPC1:
Generating mutation plots.
Highly correlated genes for GPC1:
Showing top 20/1117 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPC1 | RAB11FIP5 | 0.754977 | 3 | 0 | 3 |
| GPC1 | FKBP2 | 0.750869 | 3 | 0 | 3 |
| GPC1 | HES6 | 0.747866 | 4 | 0 | 4 |
| GPC1 | TRAF7 | 0.730907 | 4 | 0 | 4 |
| GPC1 | SGPP1 | 0.719814 | 3 | 0 | 3 |
| GPC1 | SLC26A11 | 0.719106 | 3 | 0 | 3 |
| GPC1 | ZNF317 | 0.718133 | 3 | 0 | 3 |
| GPC1 | CLCN7 | 0.717756 | 3 | 0 | 3 |
| GPC1 | GLIS2 | 0.715296 | 4 | 0 | 3 |
| GPC1 | CIAO1 | 0.715051 | 3 | 0 | 3 |
| GPC1 | DOCK11 | 0.706254 | 3 | 0 | 3 |
| GPC1 | ZC3H18 | 0.706037 | 3 | 0 | 3 |
| GPC1 | TENM2 | 0.700917 | 6 | 0 | 6 |
| GPC1 | FAM192A | 0.698451 | 3 | 0 | 3 |
| GPC1 | LRCH3 | 0.696717 | 3 | 0 | 3 |
| GPC1 | SPON2 | 0.695664 | 3 | 0 | 3 |
| GPC1 | DENND3 | 0.694732 | 3 | 0 | 3 |
| GPC1 | ADAMTS14 | 0.693487 | 3 | 0 | 3 |
| GPC1 | VAX2 | 0.69092 | 4 | 0 | 3 |
| GPC1 | SCYL1 | 0.690686 | 4 | 0 | 4 |
For details and further investigation, click here
