| Full name: dual specificity tyrosine phosphorylation regulated kinase 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p13.32 | ||
| Entrez ID: 8798 | HGNC ID: HGNC:3095 | Ensembl Gene: ENSG00000010219 | OMIM ID: 609181 |
| Drug and gene relationship at DGIdb | |||
Expression of DYRK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DYRK4 | 8798 | 212954_at | -0.0071 | 0.9934 | |
| GSE20347 | DYRK4 | 8798 | 212954_at | 0.0920 | 0.6890 | |
| GSE23400 | DYRK4 | 8798 | 212954_at | -0.0018 | 0.9768 | |
| GSE26886 | DYRK4 | 8798 | 212954_at | 0.3810 | 0.2463 | |
| GSE29001 | DYRK4 | 8798 | 212954_at | -0.0071 | 0.9809 | |
| GSE38129 | DYRK4 | 8798 | 212954_at | 0.0293 | 0.8722 | |
| GSE45670 | DYRK4 | 8798 | 212954_at | -0.0144 | 0.9646 | |
| GSE53622 | DYRK4 | 8798 | 85004 | 0.2994 | 0.0005 | |
| GSE53624 | DYRK4 | 8798 | 85004 | 0.4009 | 0.0000 | |
| GSE63941 | DYRK4 | 8798 | 212954_at | -0.2942 | 0.6625 | |
| GSE77861 | DYRK4 | 8798 | 212954_at | 0.3429 | 0.3517 | |
| GSE97050 | DYRK4 | 8798 | A_23_P87902 | 0.2481 | 0.3091 | |
| SRP007169 | DYRK4 | 8798 | RNAseq | -0.9574 | 0.0246 | |
| SRP008496 | DYRK4 | 8798 | RNAseq | -0.3043 | 0.3808 | |
| SRP064894 | DYRK4 | 8798 | RNAseq | 0.3275 | 0.2820 | |
| SRP133303 | DYRK4 | 8798 | RNAseq | 0.2914 | 0.1202 | |
| SRP159526 | DYRK4 | 8798 | RNAseq | 0.2248 | 0.4524 | |
| SRP193095 | DYRK4 | 8798 | RNAseq | -0.1305 | 0.3285 | |
| SRP219564 | DYRK4 | 8798 | RNAseq | -0.3548 | 0.4877 | |
| TCGA | DYRK4 | 8798 | RNAseq | 0.0933 | 0.2983 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DYRK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DYRK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DYRK4 | 8798 | 6 | 4 | 20 | |
| GSE20123 | DYRK4 | 8798 | 6 | 4 | 20 | |
| GSE43470 | DYRK4 | 8798 | 9 | 3 | 31 | |
| GSE46452 | DYRK4 | 8798 | 10 | 1 | 48 | |
| GSE47630 | DYRK4 | 8798 | 12 | 2 | 26 | |
| GSE54993 | DYRK4 | 8798 | 1 | 10 | 59 | |
| GSE54994 | DYRK4 | 8798 | 10 | 2 | 41 | |
| GSE60625 | DYRK4 | 8798 | 0 | 1 | 10 | |
| GSE74703 | DYRK4 | 8798 | 8 | 2 | 26 | |
| GSE74704 | DYRK4 | 8798 | 4 | 2 | 14 | |
| TCGA | DYRK4 | 8798 | 40 | 6 | 50 |
Total number of gains: 106; Total number of losses: 37; Total Number of normals: 345.
Somatic mutations of DYRK4:
Generating mutation plots.
Highly correlated genes for DYRK4:
Showing top 20/147 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DYRK4 | DHRSX | 0.71107 | 3 | 0 | 3 |
| DYRK4 | TLR1 | 0.689134 | 3 | 0 | 3 |
| DYRK4 | SOX18 | 0.686197 | 4 | 0 | 4 |
| DYRK4 | SERPINA12 | 0.684044 | 3 | 0 | 3 |
| DYRK4 | TMEM18 | 0.671364 | 3 | 0 | 3 |
| DYRK4 | KCNT2 | 0.667743 | 3 | 0 | 3 |
| DYRK4 | RPL38 | 0.647658 | 4 | 0 | 3 |
| DYRK4 | UBB | 0.646417 | 3 | 0 | 3 |
| DYRK4 | GSTA3 | 0.645777 | 3 | 0 | 3 |
| DYRK4 | FILIP1 | 0.642147 | 3 | 0 | 3 |
| DYRK4 | ACP1 | 0.636033 | 4 | 0 | 4 |
| DYRK4 | STRAP | 0.634739 | 6 | 0 | 5 |
| DYRK4 | ZNF384 | 0.633983 | 5 | 0 | 3 |
| DYRK4 | CCDC127 | 0.63081 | 3 | 0 | 3 |
| DYRK4 | PHB2 | 0.629659 | 7 | 0 | 6 |
| DYRK4 | LPGAT1 | 0.628101 | 3 | 0 | 3 |
| DYRK4 | POLK | 0.626458 | 3 | 0 | 3 |
| DYRK4 | PHTF1 | 0.625485 | 4 | 0 | 3 |
| DYRK4 | C12orf57 | 0.619646 | 7 | 0 | 5 |
| DYRK4 | NECAP1 | 0.619634 | 5 | 0 | 4 |
For details and further investigation, click here
