| Full name: LIM homeobox 2 | Alias Symbol: LH-2|hLhx2 | ||
| Type: protein-coding gene | Cytoband: 9q33.3 | ||
| Entrez ID: 9355 | HGNC ID: HGNC:6594 | Ensembl Gene: ENSG00000106689 | OMIM ID: 603759 |
| Drug and gene relationship at DGIdb | |||
Expression of LHX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LHX2 | 9355 | 211219_s_at | 0.3780 | 0.3212 | |
| GSE20347 | LHX2 | 9355 | 211219_s_at | 0.0672 | 0.2881 | |
| GSE23400 | LHX2 | 9355 | 211219_s_at | -0.0278 | 0.3796 | |
| GSE26886 | LHX2 | 9355 | 211219_s_at | 0.2668 | 0.0755 | |
| GSE29001 | LHX2 | 9355 | 206140_at | 3.9449 | 0.0000 | |
| GSE38129 | LHX2 | 9355 | 211219_s_at | 0.2230 | 0.0142 | |
| GSE45670 | LHX2 | 9355 | 211219_s_at | 0.4406 | 0.0032 | |
| GSE53622 | LHX2 | 9355 | 6933 | 1.7844 | 0.0000 | |
| GSE53624 | LHX2 | 9355 | 78775 | 4.3109 | 0.0000 | |
| GSE63941 | LHX2 | 9355 | 206140_at | 1.9387 | 0.1767 | |
| GSE77861 | LHX2 | 9355 | 211219_s_at | 0.0249 | 0.9022 | |
| GSE97050 | LHX2 | 9355 | A_23_P32165 | 0.6226 | 0.2079 | |
| SRP219564 | LHX2 | 9355 | RNAseq | 5.5878 | 0.0000 | |
| TCGA | LHX2 | 9355 | RNAseq | 3.1864 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by LHX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LHX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LHX2 | 9355 | 4 | 8 | 18 | |
| GSE20123 | LHX2 | 9355 | 4 | 8 | 18 | |
| GSE43470 | LHX2 | 9355 | 5 | 4 | 34 | |
| GSE46452 | LHX2 | 9355 | 6 | 13 | 40 | |
| GSE47630 | LHX2 | 9355 | 3 | 16 | 21 | |
| GSE54993 | LHX2 | 9355 | 3 | 3 | 64 | |
| GSE54994 | LHX2 | 9355 | 10 | 9 | 34 | |
| GSE60625 | LHX2 | 9355 | 0 | 0 | 11 | |
| GSE74703 | LHX2 | 9355 | 5 | 3 | 28 | |
| GSE74704 | LHX2 | 9355 | 2 | 6 | 12 | |
| TCGA | LHX2 | 9355 | 27 | 25 | 44 |
Total number of gains: 69; Total number of losses: 95; Total Number of normals: 324.
Somatic mutations of LHX2:
Generating mutation plots.
Highly correlated genes for LHX2:
Showing top 20/818 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LHX2 | ZIC5 | 0.720445 | 4 | 0 | 4 |
| LHX2 | SLC39A10 | 0.718413 | 3 | 0 | 3 |
| LHX2 | VAX1 | 0.704891 | 3 | 0 | 3 |
| LHX2 | LEPR | 0.694599 | 3 | 0 | 3 |
| LHX2 | PYCR2 | 0.683201 | 3 | 0 | 3 |
| LHX2 | FANCB | 0.675599 | 5 | 0 | 5 |
| LHX2 | MATN3 | 0.674471 | 4 | 0 | 4 |
| LHX2 | SLC19A1 | 0.670833 | 3 | 0 | 3 |
| LHX2 | CAGE1 | 0.669333 | 4 | 0 | 3 |
| LHX2 | AP3M2 | 0.667452 | 4 | 0 | 3 |
| LHX2 | SOX11 | 0.667211 | 3 | 0 | 3 |
| LHX2 | MCM8 | 0.665873 | 4 | 0 | 4 |
| LHX2 | C12orf60 | 0.662488 | 4 | 0 | 4 |
| LHX2 | MYPOP | 0.661757 | 4 | 0 | 4 |
| LHX2 | BTBD6 | 0.660406 | 4 | 0 | 3 |
| LHX2 | PRTFDC1 | 0.660172 | 3 | 0 | 3 |
| LHX2 | ANAPC1 | 0.659157 | 3 | 0 | 3 |
| LHX2 | PTPMT1 | 0.656747 | 3 | 0 | 3 |
| LHX2 | ATP13A3 | 0.654626 | 5 | 0 | 5 |
| LHX2 | CMTM3 | 0.65416 | 3 | 0 | 3 |
For details and further investigation, click here
