WNT2

 

Full name: Wnt family member 2 Alias Symbol: IRP
Type: protein-coding gene Cytoband: 7q31.2
Entrez ID: 7472 HGNC ID: HGNC:12780 Ensembl Gene: ENSG00000105989 OMIM ID: 147870
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

WNT2 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05217Basal cell carcinoma

 

Expression of WNT2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WNT2 7472 205648_at 1.0589 0.0357
GSE20347 WNT2 7472 205648_at 0.6729 0.0000
GSE23400 WNT2 7472 205648_at 0.1297 0.0113
GSE26886 WNT2 7472 205648_at 0.8156 0.0010
GSE29001 WNT2 7472 205648_at 0.2220 0.2615
GSE38129 WNT2 7472 205648_at 0.8404 0.0000
GSE45670 WNT2 7472 205648_at 0.6703 0.0203
GSE53622 WNT2 7472 64303 2.3904 0.0000
GSE53624 WNT2 7472 64303 4.2676 0.0000
GSE63941 WNT2 7472 205648_at -3.2417 0.0000
GSE77861 WNT2 7472 205648_at 0.1198 0.5291
SRP007169 WNT2 7472 RNAseq 7.8808 0.0000
SRP064894 WNT2 7472 RNAseq 5.3109 0.0000
SRP133303 WNT2 7472 RNAseq 6.6851 0.0000
SRP159526 WNT2 7472 RNAseq 5.5498 0.0000
SRP219564 WNT2 7472 RNAseq 5.0965 0.0000
TCGA WNT2 7472 RNAseq 2.1841 0.0000

Upregulated datasets: 9; Downregulated datasets: 1.  

 

Survival by WNT2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WNT2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WNT2 7472 9 2 19
GSE20123 WNT2 7472 10 2 18
GSE43470 WNT2 7472 3 2 38
GSE46452 WNT2 7472 8 1 50
GSE47630 WNT2 7472 7 4 29
GSE54993 WNT2 7472 2 7 61
GSE54994 WNT2 7472 12 5 36
GSE60625 WNT2 7472 0 0 11
GSE74703 WNT2 7472 3 2 31
GSE74704 WNT2 7472 7 2 11
TCGA WNT2 7472 33 17 46

Total number of gains: 94; Total number of losses: 44; Total Number of normals: 350.  

 

Somatic mutations of WNT2:

 

Generating mutation plots.

 

Highly correlated genes for WNT2:

 

Showing top 20/691 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WNT2LINC012520.698905303
WNT2CTHRC10.69547707
WNT2ADAM120.689853404
WNT2POSTN0.687782908
WNT2PTX30.686366303
WNT2COL10A10.6859181109
WNT2C18orf540.685248303
WNT2PEAK10.68303
WNT2THY10.67566310010
WNT2COL11A10.67539211010
WNT2FKBP70.674493404
WNT2S1PR30.670544303
WNT2RAB11FIP50.670232303
WNT2VCAN0.667643908
WNT2NOX40.6670711109
WNT2IFT430.665397404
WNT2ZNF7460.665289303
WNT2MMP110.664095907
WNT2ADAMTS120.662934907
WNT2CDH110.662197908

For details and further investigation, click here