| Full name: hydroxysteroid 17-beta dehydrogenase 2 | Alias Symbol: HSD17|SDR9C2 | ||
| Type: protein-coding gene | Cytoband: 16q23.3 | ||
| Entrez ID: 3294 | HGNC ID: HGNC:5211 | Ensembl Gene: ENSG00000086696 | OMIM ID: 109685 |
| Drug and gene relationship at DGIdb | |||
HSD17B2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04913 | Ovarian steroidogenesis |
Expression of HSD17B2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD17B2 | 3294 | 204818_at | 0.1887 | 0.9143 | |
| GSE20347 | HSD17B2 | 3294 | 204818_at | 0.2018 | 0.4279 | |
| GSE23400 | HSD17B2 | 3294 | 204818_at | -0.0765 | 0.0879 | |
| GSE26886 | HSD17B2 | 3294 | 204818_at | 0.1407 | 0.7167 | |
| GSE29001 | HSD17B2 | 3294 | 204818_at | 0.2275 | 0.7202 | |
| GSE38129 | HSD17B2 | 3294 | 204818_at | 0.3292 | 0.3297 | |
| GSE45670 | HSD17B2 | 3294 | 204818_at | 0.4008 | 0.4392 | |
| GSE53622 | HSD17B2 | 3294 | 101259 | -0.2698 | 0.3125 | |
| GSE53624 | HSD17B2 | 3294 | 101259 | -0.9237 | 0.0000 | |
| GSE63941 | HSD17B2 | 3294 | 204818_at | -4.7878 | 0.0002 | |
| GSE77861 | HSD17B2 | 3294 | 204818_at | 0.0783 | 0.6962 | |
| GSE97050 | HSD17B2 | 3294 | A_23_P118065 | 0.5674 | 0.3276 | |
| SRP064894 | HSD17B2 | 3294 | RNAseq | -1.3658 | 0.0034 | |
| SRP133303 | HSD17B2 | 3294 | RNAseq | -0.8079 | 0.1050 | |
| SRP159526 | HSD17B2 | 3294 | RNAseq | -0.9989 | 0.0730 | |
| TCGA | HSD17B2 | 3294 | RNAseq | -0.9215 | 0.0272 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HSD17B2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD17B2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD17B2 | 3294 | 5 | 3 | 22 | |
| GSE20123 | HSD17B2 | 3294 | 5 | 2 | 23 | |
| GSE43470 | HSD17B2 | 3294 | 2 | 9 | 32 | |
| GSE46452 | HSD17B2 | 3294 | 37 | 2 | 20 | |
| GSE47630 | HSD17B2 | 3294 | 11 | 9 | 20 | |
| GSE54993 | HSD17B2 | 3294 | 2 | 4 | 64 | |
| GSE54994 | HSD17B2 | 3294 | 7 | 10 | 36 | |
| GSE60625 | HSD17B2 | 3294 | 4 | 0 | 7 | |
| GSE74703 | HSD17B2 | 3294 | 2 | 7 | 27 | |
| GSE74704 | HSD17B2 | 3294 | 3 | 2 | 15 | |
| TCGA | HSD17B2 | 3294 | 24 | 16 | 56 |
Total number of gains: 102; Total number of losses: 64; Total Number of normals: 322.
Somatic mutations of HSD17B2:
Generating mutation plots.
Highly correlated genes for HSD17B2:
Showing top 20/88 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD17B2 | SMIM3 | 0.740383 | 3 | 0 | 3 |
| HSD17B2 | PCOLCE | 0.703459 | 3 | 0 | 3 |
| HSD17B2 | PLAT | 0.667823 | 4 | 0 | 4 |
| HSD17B2 | STARD13 | 0.665627 | 3 | 0 | 3 |
| HSD17B2 | REEP5 | 0.663224 | 3 | 0 | 3 |
| HSD17B2 | TCF21 | 0.662825 | 3 | 0 | 3 |
| HSD17B2 | CEMIP | 0.64705 | 3 | 0 | 3 |
| HSD17B2 | TPM4 | 0.642039 | 3 | 0 | 3 |
| HSD17B2 | EDNRA | 0.639185 | 3 | 0 | 3 |
| HSD17B2 | PLIN5 | 0.631674 | 4 | 0 | 3 |
| HSD17B2 | CHN1 | 0.62575 | 3 | 0 | 3 |
| HSD17B2 | MSRB1 | 0.625462 | 3 | 0 | 3 |
| HSD17B2 | SLC28A3 | 0.62537 | 4 | 0 | 3 |
| HSD17B2 | SLC22A4 | 0.618657 | 4 | 0 | 3 |
| HSD17B2 | TNFRSF11B | 0.618178 | 6 | 0 | 4 |
| HSD17B2 | LINC00597 | 0.615426 | 4 | 0 | 3 |
| HSD17B2 | LOX | 0.615047 | 4 | 0 | 3 |
| HSD17B2 | ADAMTS3 | 0.613077 | 4 | 0 | 3 |
| HSD17B2 | COLEC12 | 0.611478 | 4 | 0 | 3 |
| HSD17B2 | ARL15 | 0.611089 | 4 | 0 | 4 |
For details and further investigation, click here
