| Full name: leucine rich repeat and Ig domain containing 1 | Alias Symbol: FLJ14594|LERN1 | ||
| Type: protein-coding gene | Cytoband: 15q24.3 | ||
| Entrez ID: 84894 | HGNC ID: HGNC:21205 | Ensembl Gene: ENSG00000169783 | OMIM ID: 609791 |
| Drug and gene relationship at DGIdb | |||
Expression of LINGO1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LINGO1 | 84894 | 227933_at | 0.3172 | 0.1787 | |
| GSE26886 | LINGO1 | 84894 | 227933_at | 0.5922 | 0.0184 | |
| GSE45670 | LINGO1 | 84894 | 227933_at | -0.1519 | 0.4275 | |
| GSE53622 | LINGO1 | 84894 | 35363 | 0.5077 | 0.0004 | |
| GSE53624 | LINGO1 | 84894 | 49853 | 1.0921 | 0.0000 | |
| GSE63941 | LINGO1 | 84894 | 227933_at | 0.6347 | 0.3091 | |
| GSE77861 | LINGO1 | 84894 | 227933_at | -0.0002 | 0.9989 | |
| GSE97050 | LINGO1 | 84894 | A_33_P3399228 | 0.3134 | 0.1839 | |
| SRP064894 | LINGO1 | 84894 | RNAseq | 0.7677 | 0.1144 | |
| SRP133303 | LINGO1 | 84894 | RNAseq | -0.3205 | 0.2119 | |
| SRP159526 | LINGO1 | 84894 | RNAseq | 2.2755 | 0.0013 | |
| TCGA | LINGO1 | 84894 | RNAseq | 0.4407 | 0.0262 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LINGO1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LINGO1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LINGO1 | 84894 | 7 | 1 | 22 | |
| GSE20123 | LINGO1 | 84894 | 7 | 1 | 22 | |
| GSE43470 | LINGO1 | 84894 | 4 | 5 | 34 | |
| GSE46452 | LINGO1 | 84894 | 3 | 7 | 49 | |
| GSE47630 | LINGO1 | 84894 | 8 | 10 | 22 | |
| GSE54993 | LINGO1 | 84894 | 5 | 6 | 59 | |
| GSE54994 | LINGO1 | 84894 | 5 | 6 | 42 | |
| GSE60625 | LINGO1 | 84894 | 4 | 0 | 7 | |
| GSE74703 | LINGO1 | 84894 | 4 | 3 | 29 | |
| GSE74704 | LINGO1 | 84894 | 4 | 1 | 15 | |
| TCGA | LINGO1 | 84894 | 14 | 15 | 67 |
Total number of gains: 65; Total number of losses: 55; Total Number of normals: 368.
Somatic mutations of LINGO1:
Generating mutation plots.
Highly correlated genes for LINGO1:
Showing top 20/456 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LINGO1 | PLEKHA4 | 0.797648 | 3 | 0 | 3 |
| LINGO1 | SUPT7L | 0.796407 | 3 | 0 | 3 |
| LINGO1 | ADCY3 | 0.792683 | 3 | 0 | 3 |
| LINGO1 | TNS4 | 0.784386 | 3 | 0 | 3 |
| LINGO1 | SUPT16H | 0.781916 | 3 | 0 | 3 |
| LINGO1 | RAB7B | 0.778829 | 3 | 0 | 3 |
| LINGO1 | PHRF1 | 0.770285 | 3 | 0 | 3 |
| LINGO1 | INO80E | 0.766441 | 3 | 0 | 3 |
| LINGO1 | KIAA0930 | 0.761306 | 3 | 0 | 3 |
| LINGO1 | WDR43 | 0.754765 | 3 | 0 | 3 |
| LINGO1 | TKT | 0.754093 | 3 | 0 | 3 |
| LINGO1 | RNF187 | 0.753364 | 3 | 0 | 3 |
| LINGO1 | PDGFB | 0.751978 | 3 | 0 | 3 |
| LINGO1 | MICALL2 | 0.749049 | 3 | 0 | 3 |
| LINGO1 | VAMP2 | 0.74614 | 3 | 0 | 3 |
| LINGO1 | PSMD2 | 0.742798 | 3 | 0 | 3 |
| LINGO1 | SLC9A1 | 0.740262 | 3 | 0 | 3 |
| LINGO1 | SSBP4 | 0.734067 | 3 | 0 | 3 |
| LINGO1 | AGTRAP | 0.734004 | 3 | 0 | 3 |
| LINGO1 | FKBP10 | 0.733053 | 3 | 0 | 3 |
For details and further investigation, click here
