IL1B

 

Full name: interleukin 1 beta Alias Symbol: IL1F2|IL-1B|IL1-BETA
Type: protein-coding gene Cytoband: 2q14.1
Entrez ID: 3553 HGNC ID: HGNC:5992 Ensembl Gene: ENSG00000125538 OMIM ID: 147720
Drug and gene relationship at DGIdb

 

IL1B involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05132Salmonella infection
hsa05133Pertussis
hsa05134Legionellosis
hsa05152Tuberculosis
hsa05164Influenza A

 

Expression of IL1B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IL1B 3553 205067_at 1.6838 0.2917
GSE20347 IL1B 3553 39402_at 0.2017 0.4576
GSE23400 IL1B 3553 205067_at 0.0798 0.3325
GSE26886 IL1B 3553 39402_at -0.0673 0.8680
GSE29001 IL1B 3553 39402_at -0.5020 0.1139
GSE38129 IL1B 3553 39402_at 0.5200 0.1229
GSE45670 IL1B 3553 39402_at 1.4465 0.0076
GSE53622 IL1B 3553 33613 1.2362 0.0000
GSE53624 IL1B 3553 33613 1.1379 0.0000
GSE63941 IL1B 3553 205067_at 0.9663 0.4508
GSE77861 IL1B 3553 39402_at 1.4233 0.0028
GSE97050 IL1B 3553 A_23_P79518 1.2312 0.1834
SRP007169 IL1B 3553 RNAseq 1.2250 0.0067
SRP064894 IL1B 3553 RNAseq 2.6001 0.0000
SRP133303 IL1B 3553 RNAseq 2.9842 0.0000
SRP159526 IL1B 3553 RNAseq 1.6043 0.0017
SRP193095 IL1B 3553 RNAseq 2.5828 0.0000
SRP219564 IL1B 3553 RNAseq 1.4216 0.1410
TCGA IL1B 3553 RNAseq 0.4262 0.0443

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by IL1B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IL1B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IL1B 3553 6 2 22
GSE20123 IL1B 3553 6 2 22
GSE43470 IL1B 3553 3 1 39
GSE46452 IL1B 3553 1 4 54
GSE47630 IL1B 3553 7 0 33
GSE54993 IL1B 3553 0 6 64
GSE54994 IL1B 3553 10 0 43
GSE60625 IL1B 3553 0 3 8
GSE74703 IL1B 3553 3 1 32
GSE74704 IL1B 3553 3 2 15
TCGA IL1B 3553 31 6 59

Total number of gains: 70; Total number of losses: 27; Total Number of normals: 391.  

 

Somatic mutations of IL1B:

 

Generating mutation plots.

 

Highly correlated genes for IL1B:

 

Showing top 20/549 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IL1BADCY30.777362303
IL1BGCLC0.764969303
IL1BKHSRP0.743008303
IL1BCDCA20.736065404
IL1BDDX110.730975303
IL1BPTCD30.728283404
IL1BCHRNA50.722783303
IL1BSLC6A150.721658303
IL1BPOLR3D0.72139303
IL1BGSR0.708359404
IL1BSPRY4-IT10.707572303
IL1BRAB230.7034303
IL1BLEPROTL10.699287303
IL1BWDR540.696629606
IL1BIAH10.696138303
IL1BBLACAT10.694828303
IL1BCXCL80.6894091009
IL1BC12orf750.68626503
IL1BILF30.684448303
IL1BEME10.683063404

For details and further investigation, click here