| Full name: phospholipase A2 group III | Alias Symbol: GIII-SPLA2 | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 50487 | HGNC ID: HGNC:17934 | Ensembl Gene: ENSG00000100078 | OMIM ID: 611651 |
| Drug and gene relationship at DGIdb | |||
PLA2G3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04270 | Vascular smooth muscle contraction |
Expression of PLA2G3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLA2G3 | 50487 | 220780_at | -0.4264 | 0.5566 | |
| GSE20347 | PLA2G3 | 50487 | 220780_at | -0.2130 | 0.2702 | |
| GSE23400 | PLA2G3 | 50487 | 220780_at | -0.1958 | 0.0084 | |
| GSE26886 | PLA2G3 | 50487 | 220780_at | -0.2727 | 0.4130 | |
| GSE29001 | PLA2G3 | 50487 | 220780_at | -0.3158 | 0.4026 | |
| GSE38129 | PLA2G3 | 50487 | 220780_at | -0.1375 | 0.4992 | |
| GSE45670 | PLA2G3 | 50487 | 220780_at | 0.4844 | 0.2067 | |
| GSE53622 | PLA2G3 | 50487 | 19560 | -1.0389 | 0.0012 | |
| GSE53624 | PLA2G3 | 50487 | 19560 | -1.1350 | 0.0000 | |
| GSE63941 | PLA2G3 | 50487 | 220780_at | 0.2892 | 0.3645 | |
| GSE77861 | PLA2G3 | 50487 | 220780_at | 0.1048 | 0.7272 | |
| SRP007169 | PLA2G3 | 50487 | RNAseq | 0.1010 | 0.8782 | |
| SRP064894 | PLA2G3 | 50487 | RNAseq | -1.8860 | 0.0011 | |
| SRP133303 | PLA2G3 | 50487 | RNAseq | 0.4960 | 0.6346 | |
| SRP159526 | PLA2G3 | 50487 | RNAseq | -0.6212 | 0.4822 | |
| TCGA | PLA2G3 | 50487 | RNAseq | 0.8779 | 0.0862 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PLA2G3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLA2G3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLA2G3 | 50487 | 4 | 5 | 21 | |
| GSE20123 | PLA2G3 | 50487 | 4 | 4 | 22 | |
| GSE43470 | PLA2G3 | 50487 | 4 | 5 | 34 | |
| GSE46452 | PLA2G3 | 50487 | 31 | 1 | 27 | |
| GSE47630 | PLA2G3 | 50487 | 8 | 5 | 27 | |
| GSE54993 | PLA2G3 | 50487 | 3 | 6 | 61 | |
| GSE54994 | PLA2G3 | 50487 | 12 | 7 | 34 | |
| GSE60625 | PLA2G3 | 50487 | 5 | 0 | 6 | |
| GSE74703 | PLA2G3 | 50487 | 4 | 5 | 27 | |
| GSE74704 | PLA2G3 | 50487 | 1 | 1 | 18 | |
| TCGA | PLA2G3 | 50487 | 27 | 15 | 54 |
Total number of gains: 103; Total number of losses: 54; Total Number of normals: 331.
Somatic mutations of PLA2G3:
Generating mutation plots.
Highly correlated genes for PLA2G3:
Showing top 20/135 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLA2G3 | OGFOD1 | 0.676901 | 3 | 0 | 3 |
| PLA2G3 | KIAA1614 | 0.661255 | 3 | 0 | 3 |
| PLA2G3 | TMPRSS15 | 0.657036 | 3 | 0 | 3 |
| PLA2G3 | PHF7 | 0.648119 | 4 | 0 | 4 |
| PLA2G3 | FOXN3-AS1 | 0.645277 | 3 | 0 | 3 |
| PLA2G3 | IL11 | 0.642861 | 3 | 0 | 3 |
| PLA2G3 | RGSL1 | 0.64022 | 5 | 0 | 5 |
| PLA2G3 | ADCY8 | 0.632861 | 3 | 0 | 3 |
| PLA2G3 | F11 | 0.622193 | 3 | 0 | 3 |
| PLA2G3 | ITGB3 | 0.614346 | 3 | 0 | 3 |
| PLA2G3 | HDLBP | 0.612123 | 3 | 0 | 3 |
| PLA2G3 | RHAG | 0.605763 | 4 | 0 | 3 |
| PLA2G3 | CCDC30 | 0.604293 | 5 | 0 | 5 |
| PLA2G3 | OR12D2 | 0.601408 | 3 | 0 | 3 |
| PLA2G3 | NR5A1 | 0.598145 | 4 | 0 | 3 |
| PLA2G3 | AGTR2 | 0.597844 | 3 | 0 | 3 |
| PLA2G3 | BOK | 0.593859 | 4 | 0 | 3 |
| PLA2G3 | MMP8 | 0.592084 | 3 | 0 | 3 |
| PLA2G3 | LIPF | 0.591025 | 3 | 0 | 3 |
| PLA2G3 | NHLH1 | 0.586501 | 4 | 0 | 3 |
For details and further investigation, click here
