| Full name: potassium inwardly rectifying channel subfamily J member 4 | Alias Symbol: Kir2.3|HIR|HRK1|hIRK2|IRK3 | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 3761 | HGNC ID: HGNC:6265 | Ensembl Gene: ENSG00000168135 | OMIM ID: 600504 |
| Drug and gene relationship at DGIdb | |||
KCNJ4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04921 | Oxytocin signaling pathway |
Expression of KCNJ4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNJ4 | 3761 | 208359_s_at | -0.0035 | 0.9924 | |
| GSE20347 | KCNJ4 | 3761 | 208359_s_at | 0.0573 | 0.4069 | |
| GSE23400 | KCNJ4 | 3761 | 211451_s_at | -0.1672 | 0.0000 | |
| GSE26886 | KCNJ4 | 3761 | 211451_s_at | 0.0401 | 0.7717 | |
| GSE29001 | KCNJ4 | 3761 | 208359_s_at | 0.0600 | 0.7940 | |
| GSE38129 | KCNJ4 | 3761 | 211451_s_at | -0.1007 | 0.1269 | |
| GSE45670 | KCNJ4 | 3761 | 211451_s_at | -0.1060 | 0.3034 | |
| GSE63941 | KCNJ4 | 3761 | 208359_s_at | 0.5991 | 0.0545 | |
| GSE77861 | KCNJ4 | 3761 | 211451_s_at | -0.3308 | 0.0907 | |
| GSE97050 | KCNJ4 | 3761 | A_24_P6125 | -0.0432 | 0.8853 | |
| TCGA | KCNJ4 | 3761 | RNAseq | 2.9800 | 0.0088 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by KCNJ4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KCNJ4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNJ4 | 3761 | 6 | 5 | 19 | |
| GSE20123 | KCNJ4 | 3761 | 6 | 4 | 20 | |
| GSE43470 | KCNJ4 | 3761 | 5 | 5 | 33 | |
| GSE46452 | KCNJ4 | 3761 | 32 | 2 | 25 | |
| GSE47630 | KCNJ4 | 3761 | 9 | 4 | 27 | |
| GSE54993 | KCNJ4 | 3761 | 3 | 6 | 61 | |
| GSE54994 | KCNJ4 | 3761 | 9 | 7 | 37 | |
| GSE60625 | KCNJ4 | 3761 | 5 | 0 | 6 | |
| GSE74703 | KCNJ4 | 3761 | 5 | 4 | 27 | |
| GSE74704 | KCNJ4 | 3761 | 3 | 2 | 15 | |
| TCGA | KCNJ4 | 3761 | 28 | 15 | 53 |
Total number of gains: 111; Total number of losses: 54; Total Number of normals: 323.
Somatic mutations of KCNJ4:
Generating mutation plots.
Highly correlated genes for KCNJ4:
Showing top 20/340 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNJ4 | AVPR1A | 0.748706 | 3 | 0 | 3 |
| KCNJ4 | OR3A1 | 0.738595 | 3 | 0 | 3 |
| KCNJ4 | HCG9 | 0.702191 | 3 | 0 | 3 |
| KCNJ4 | SPAG11A | 0.701499 | 3 | 0 | 3 |
| KCNJ4 | BRS3 | 0.699534 | 3 | 0 | 3 |
| KCNJ4 | KCNQ3 | 0.698893 | 3 | 0 | 3 |
| KCNJ4 | IGLL1 | 0.698356 | 4 | 0 | 4 |
| KCNJ4 | SLC6A3 | 0.686108 | 3 | 0 | 3 |
| KCNJ4 | MAG | 0.685009 | 3 | 0 | 3 |
| KCNJ4 | ACTR8 | 0.68487 | 3 | 0 | 3 |
| KCNJ4 | TAS2R1 | 0.681334 | 3 | 0 | 3 |
| KCNJ4 | BRINP2 | 0.679815 | 3 | 0 | 3 |
| KCNJ4 | NR1I3 | 0.6755 | 3 | 0 | 3 |
| KCNJ4 | FGF23 | 0.673949 | 3 | 0 | 3 |
| KCNJ4 | DUSP21 | 0.668205 | 3 | 0 | 3 |
| KCNJ4 | C4BPB | 0.666074 | 3 | 0 | 3 |
| KCNJ4 | S100A1 | 0.662406 | 4 | 0 | 3 |
| KCNJ4 | IL9 | 0.661853 | 3 | 0 | 3 |
| KCNJ4 | PGLYRP1 | 0.65681 | 4 | 0 | 3 |
| KCNJ4 | ADAM30 | 0.655729 | 4 | 0 | 4 |
For details and further investigation, click here
