| Full name: spectrin beta, erythrocytic | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q23.3 | ||
| Entrez ID: 6710 | HGNC ID: HGNC:11274 | Ensembl Gene: ENSG00000070182 | OMIM ID: 182870 |
| Drug and gene relationship at DGIdb | |||
Expression of SPTB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPTB | 6710 | 208416_s_at | 0.1933 | 0.5324 | |
| GSE20347 | SPTB | 6710 | 208416_s_at | 0.0774 | 0.3752 | |
| GSE23400 | SPTB | 6710 | 208416_s_at | -0.0616 | 0.1365 | |
| GSE26886 | SPTB | 6710 | 214145_s_at | 0.1609 | 0.1432 | |
| GSE29001 | SPTB | 6710 | 214145_s_at | 0.0640 | 0.7203 | |
| GSE38129 | SPTB | 6710 | 208416_s_at | 0.0099 | 0.9089 | |
| GSE45670 | SPTB | 6710 | 208416_s_at | 0.3181 | 0.0003 | |
| GSE53622 | SPTB | 6710 | 33147 | 0.2069 | 0.0036 | |
| GSE53624 | SPTB | 6710 | 33147 | 0.3778 | 0.0000 | |
| GSE63941 | SPTB | 6710 | 208416_s_at | 0.0329 | 0.8644 | |
| GSE77861 | SPTB | 6710 | 214145_s_at | -0.0916 | 0.6010 | |
| GSE97050 | SPTB | 6710 | A_32_P134968 | -0.0717 | 0.8323 | |
| SRP133303 | SPTB | 6710 | RNAseq | 0.2790 | 0.3064 | |
| SRP159526 | SPTB | 6710 | RNAseq | 2.9289 | 0.0002 | |
| SRP219564 | SPTB | 6710 | RNAseq | 1.4604 | 0.0235 | |
| TCGA | SPTB | 6710 | RNAseq | 0.1161 | 0.2953 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SPTB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPTB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPTB | 6710 | 7 | 3 | 20 | |
| GSE20123 | SPTB | 6710 | 7 | 3 | 20 | |
| GSE43470 | SPTB | 6710 | 8 | 2 | 33 | |
| GSE46452 | SPTB | 6710 | 16 | 3 | 40 | |
| GSE47630 | SPTB | 6710 | 11 | 9 | 20 | |
| GSE54993 | SPTB | 6710 | 3 | 9 | 58 | |
| GSE54994 | SPTB | 6710 | 18 | 5 | 30 | |
| GSE60625 | SPTB | 6710 | 0 | 2 | 9 | |
| GSE74703 | SPTB | 6710 | 7 | 2 | 27 | |
| GSE74704 | SPTB | 6710 | 3 | 2 | 15 | |
| TCGA | SPTB | 6710 | 32 | 14 | 50 |
Total number of gains: 112; Total number of losses: 54; Total Number of normals: 322.
Somatic mutations of SPTB:
Generating mutation plots.
Highly correlated genes for SPTB:
Showing top 20/682 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPTB | RASL10B | 0.735867 | 3 | 0 | 3 |
| SPTB | ADRA2B | 0.728948 | 3 | 0 | 3 |
| SPTB | SLC18A3 | 0.721797 | 3 | 0 | 3 |
| SPTB | PSPN | 0.713632 | 4 | 0 | 4 |
| SPTB | SCNN1D | 0.711123 | 3 | 0 | 3 |
| SPTB | PRAMEF12 | 0.699611 | 5 | 0 | 5 |
| SPTB | OR1F1 | 0.69886 | 6 | 0 | 6 |
| SPTB | ZC3H10 | 0.695799 | 3 | 0 | 3 |
| SPTB | MYO15B | 0.693659 | 3 | 0 | 3 |
| SPTB | SIRPB1 | 0.693468 | 3 | 0 | 3 |
| SPTB | PRKAR1B | 0.692916 | 3 | 0 | 3 |
| SPTB | DAB1 | 0.692032 | 5 | 0 | 5 |
| SPTB | ISLR2 | 0.689366 | 4 | 0 | 3 |
| SPTB | CST8 | 0.684363 | 3 | 0 | 3 |
| SPTB | STK11 | 0.679881 | 3 | 0 | 3 |
| SPTB | ITGA2B | 0.6744 | 4 | 0 | 4 |
| SPTB | SPTA1 | 0.66739 | 4 | 0 | 3 |
| SPTB | SLC6A3 | 0.666388 | 6 | 0 | 5 |
| SPTB | FBXL18 | 0.665969 | 3 | 0 | 3 |
| SPTB | LMAN1L | 0.665896 | 6 | 0 | 5 |
For details and further investigation, click here
