| Full name: chondroadherin | Alias Symbol: SLRR4A | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 1101 | HGNC ID: HGNC:1909 | Ensembl Gene: ENSG00000136457 | OMIM ID: 602178 |
| Drug and gene relationship at DGIdb | |||
CHAD involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of CHAD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHAD | 1101 | 206869_at | -0.2073 | 0.5676 | |
| GSE20347 | CHAD | 1101 | 206869_at | -0.1240 | 0.2429 | |
| GSE23400 | CHAD | 1101 | 206869_at | -0.1036 | 0.0007 | |
| GSE26886 | CHAD | 1101 | 206869_at | 0.0291 | 0.8243 | |
| GSE29001 | CHAD | 1101 | 206869_at | -0.3376 | 0.0049 | |
| GSE38129 | CHAD | 1101 | 206869_at | -0.1830 | 0.0226 | |
| GSE45670 | CHAD | 1101 | 206869_at | 0.0053 | 0.9667 | |
| GSE53622 | CHAD | 1101 | 66482 | -1.5252 | 0.0000 | |
| GSE53624 | CHAD | 1101 | 66482 | -1.4143 | 0.0000 | |
| GSE63941 | CHAD | 1101 | 206869_at | 0.1575 | 0.3518 | |
| GSE77861 | CHAD | 1101 | 206869_at | -0.1128 | 0.3719 | |
| SRP064894 | CHAD | 1101 | RNAseq | -2.0611 | 0.0000 | |
| SRP133303 | CHAD | 1101 | RNAseq | -1.2940 | 0.0000 | |
| SRP159526 | CHAD | 1101 | RNAseq | -0.8743 | 0.3337 | |
| TCGA | CHAD | 1101 | RNAseq | -2.1409 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by CHAD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHAD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHAD | 1101 | 5 | 2 | 23 | |
| GSE20123 | CHAD | 1101 | 5 | 2 | 23 | |
| GSE43470 | CHAD | 1101 | 3 | 2 | 38 | |
| GSE46452 | CHAD | 1101 | 32 | 0 | 27 | |
| GSE47630 | CHAD | 1101 | 9 | 0 | 31 | |
| GSE54993 | CHAD | 1101 | 2 | 4 | 64 | |
| GSE54994 | CHAD | 1101 | 9 | 6 | 38 | |
| GSE60625 | CHAD | 1101 | 4 | 0 | 7 | |
| GSE74703 | CHAD | 1101 | 3 | 2 | 31 | |
| GSE74704 | CHAD | 1101 | 4 | 1 | 15 | |
| TCGA | CHAD | 1101 | 27 | 7 | 62 |
Total number of gains: 103; Total number of losses: 26; Total Number of normals: 359.
Somatic mutations of CHAD:
Generating mutation plots.
Highly correlated genes for CHAD:
Showing top 20/511 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHAD | TUB | 0.724747 | 4 | 0 | 4 |
| CHAD | IL2RG | 0.705175 | 3 | 0 | 3 |
| CHAD | TUBB4A | 0.684046 | 4 | 0 | 4 |
| CHAD | RAX | 0.67775 | 5 | 0 | 4 |
| CHAD | EDA2R | 0.670239 | 5 | 0 | 5 |
| CHAD | TSSK2 | 0.665323 | 7 | 0 | 7 |
| CHAD | CYP2A6 | 0.662582 | 6 | 0 | 6 |
| CHAD | RHBG | 0.662212 | 5 | 0 | 5 |
| CHAD | NAAA | 0.661725 | 5 | 0 | 3 |
| CHAD | KIR2DS4 | 0.66162 | 4 | 0 | 4 |
| CHAD | GH2 | 0.660434 | 5 | 0 | 4 |
| CHAD | KRTAP5-9 | 0.649963 | 4 | 0 | 4 |
| CHAD | CHST9 | 0.649289 | 3 | 0 | 3 |
| CHAD | BTNL3 | 0.648976 | 5 | 0 | 5 |
| CHAD | NXPE4 | 0.648024 | 7 | 0 | 6 |
| CHAD | DSCR4 | 0.646604 | 6 | 0 | 6 |
| CHAD | SCTR | 0.646139 | 5 | 0 | 5 |
| CHAD | MUC5AC | 0.644639 | 7 | 0 | 6 |
| CHAD | FAM107B | 0.642757 | 3 | 0 | 3 |
| CHAD | DUX1 | 0.641114 | 6 | 0 | 5 |
For details and further investigation, click here
