| Full name: chromosome 6 open reading frame 58 | Alias Symbol: LEG1 | ||
| Type: protein-coding gene | Cytoband: 6q22.33 | ||
| Entrez ID: 352999 | HGNC ID: HGNC:20960 | Ensembl Gene: ENSG00000184530 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of C6orf58:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C6orf58 | 352999 | 238383_at | -1.4983 | 0.1809 | |
| GSE26886 | C6orf58 | 352999 | 238385_at | 0.1056 | 0.2841 | |
| GSE45670 | C6orf58 | 352999 | 238383_at | -1.6640 | 0.0306 | |
| GSE53622 | C6orf58 | 352999 | 89468 | -3.0799 | 0.0000 | |
| GSE53624 | C6orf58 | 352999 | 89468 | -3.0917 | 0.0000 | |
| GSE63941 | C6orf58 | 352999 | 238383_at | 0.0777 | 0.7276 | |
| GSE77861 | C6orf58 | 352999 | 238385_at | -0.0719 | 0.5116 | |
| GSE97050 | C6orf58 | 352999 | A_23_P93602 | -0.3482 | 0.2237 | |
| SRP133303 | C6orf58 | 352999 | RNAseq | -6.9888 | 0.0000 | |
| TCGA | C6orf58 | 352999 | RNAseq | -2.1981 | 0.1086 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by C6orf58 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of C6orf58:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C6orf58 | 352999 | 1 | 4 | 25 | |
| GSE20123 | C6orf58 | 352999 | 2 | 3 | 25 | |
| GSE43470 | C6orf58 | 352999 | 5 | 0 | 38 | |
| GSE46452 | C6orf58 | 352999 | 2 | 11 | 46 | |
| GSE47630 | C6orf58 | 352999 | 9 | 4 | 27 | |
| GSE54993 | C6orf58 | 352999 | 3 | 3 | 64 | |
| GSE54994 | C6orf58 | 352999 | 9 | 7 | 37 | |
| GSE60625 | C6orf58 | 352999 | 0 | 1 | 10 | |
| GSE74703 | C6orf58 | 352999 | 4 | 0 | 32 | |
| GSE74704 | C6orf58 | 352999 | 0 | 1 | 19 | |
| TCGA | C6orf58 | 352999 | 10 | 18 | 68 |
Total number of gains: 45; Total number of losses: 52; Total Number of normals: 391.
Somatic mutations of C6orf58:
Generating mutation plots.
Highly correlated genes for C6orf58:
Showing top 20/67 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C6orf58 | BPIFB1 | 0.896164 | 5 | 0 | 5 |
| C6orf58 | PIGR | 0.878666 | 4 | 0 | 4 |
| C6orf58 | SCGB2A2 | 0.846646 | 4 | 0 | 4 |
| C6orf58 | AZGP1 | 0.843323 | 5 | 0 | 5 |
| C6orf58 | TFF3 | 0.832303 | 6 | 0 | 6 |
| C6orf58 | MUC5B | 0.822525 | 6 | 0 | 5 |
| C6orf58 | BPIFB2 | 0.77927 | 7 | 0 | 5 |
| C6orf58 | TSPAN8 | 0.777046 | 6 | 0 | 5 |
| C6orf58 | STATH | 0.777028 | 5 | 0 | 5 |
| C6orf58 | ZG16B | 0.776161 | 6 | 0 | 5 |
| C6orf58 | SCGB3A1 | 0.763377 | 6 | 0 | 5 |
| C6orf58 | TFF1 | 0.763098 | 5 | 0 | 5 |
| C6orf58 | LRRC26 | 0.75502 | 3 | 0 | 3 |
| C6orf58 | CHRM1 | 0.740988 | 4 | 0 | 4 |
| C6orf58 | DMBT1 | 0.736871 | 5 | 0 | 5 |
| C6orf58 | SCGB1D2 | 0.729698 | 6 | 0 | 5 |
| C6orf58 | PIP | 0.71677 | 5 | 0 | 4 |
| C6orf58 | MSMB | 0.706535 | 5 | 0 | 5 |
| C6orf58 | GP2 | 0.70383 | 6 | 0 | 5 |
| C6orf58 | MIA | 0.702775 | 5 | 0 | 4 |
For details and further investigation, click here
