| Full name: N-acylsphingosine amidohydrolase 1 | Alias Symbol: AC|PHP32|FLJ21558|ACDase | ||
| Type: protein-coding gene | Cytoband: 8p22 | ||
| Entrez ID: 427 | HGNC ID: HGNC:735 | Ensembl Gene: ENSG00000104763 | OMIM ID: 613468 |
| Drug and gene relationship at DGIdb | |||
Expression of ASAH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASAH1 | 427 | 213702_x_at | -0.3428 | 0.2327 | |
| GSE20347 | ASAH1 | 427 | 213702_x_at | -0.9232 | 0.0000 | |
| GSE23400 | ASAH1 | 427 | 213702_x_at | -0.7319 | 0.0000 | |
| GSE26886 | ASAH1 | 427 | 213702_x_at | -1.0537 | 0.0000 | |
| GSE29001 | ASAH1 | 427 | 213702_x_at | -0.7744 | 0.0039 | |
| GSE38129 | ASAH1 | 427 | 213702_x_at | -0.9313 | 0.0000 | |
| GSE45670 | ASAH1 | 427 | 213702_x_at | -0.5637 | 0.0044 | |
| GSE53622 | ASAH1 | 427 | 142232 | -1.1843 | 0.0000 | |
| GSE53624 | ASAH1 | 427 | 142232 | -1.2059 | 0.0000 | |
| GSE63941 | ASAH1 | 427 | 213702_x_at | -1.3940 | 0.0140 | |
| GSE77861 | ASAH1 | 427 | 213702_x_at | -0.8208 | 0.0660 | |
| GSE97050 | ASAH1 | 427 | A_33_P3284463 | -0.7095 | 0.1852 | |
| SRP007169 | ASAH1 | 427 | RNAseq | -1.5634 | 0.0004 | |
| SRP008496 | ASAH1 | 427 | RNAseq | -1.6645 | 0.0000 | |
| SRP064894 | ASAH1 | 427 | RNAseq | -0.5372 | 0.0288 | |
| SRP133303 | ASAH1 | 427 | RNAseq | -0.7566 | 0.0001 | |
| SRP159526 | ASAH1 | 427 | RNAseq | -1.0565 | 0.0027 | |
| SRP193095 | ASAH1 | 427 | RNAseq | -1.2119 | 0.0000 | |
| SRP219564 | ASAH1 | 427 | RNAseq | -0.7895 | 0.0069 | |
| TCGA | ASAH1 | 427 | RNAseq | -0.2170 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by ASAH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASAH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASAH1 | 427 | 3 | 10 | 17 | |
| GSE20123 | ASAH1 | 427 | 4 | 10 | 16 | |
| GSE43470 | ASAH1 | 427 | 4 | 8 | 31 | |
| GSE46452 | ASAH1 | 427 | 14 | 13 | 32 | |
| GSE47630 | ASAH1 | 427 | 10 | 8 | 22 | |
| GSE54993 | ASAH1 | 427 | 2 | 14 | 54 | |
| GSE54994 | ASAH1 | 427 | 8 | 18 | 27 | |
| GSE60625 | ASAH1 | 427 | 3 | 0 | 8 | |
| GSE74703 | ASAH1 | 427 | 4 | 7 | 25 | |
| GSE74704 | ASAH1 | 427 | 3 | 7 | 10 | |
| TCGA | ASAH1 | 427 | 14 | 40 | 42 |
Total number of gains: 69; Total number of losses: 135; Total Number of normals: 284.
Somatic mutations of ASAH1:
Generating mutation plots.
Highly correlated genes for ASAH1:
Showing top 20/1728 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASAH1 | AK3 | 0.791589 | 6 | 0 | 6 |
| ASAH1 | CAPN14 | 0.781725 | 6 | 0 | 6 |
| ASAH1 | PLEKHA7 | 0.775612 | 7 | 0 | 7 |
| ASAH1 | SPAG17 | 0.768287 | 4 | 0 | 4 |
| ASAH1 | MAL | 0.76653 | 10 | 0 | 10 |
| ASAH1 | HPGD | 0.766424 | 11 | 0 | 11 |
| ASAH1 | PRSS27 | 0.760105 | 6 | 0 | 6 |
| ASAH1 | GPD1L | 0.757378 | 11 | 0 | 11 |
| ASAH1 | CAPNS2 | 0.756742 | 4 | 0 | 4 |
| ASAH1 | CCNG2 | 0.754484 | 12 | 0 | 12 |
| ASAH1 | SASH1 | 0.749797 | 12 | 0 | 12 |
| ASAH1 | SPINK7 | 0.74866 | 6 | 0 | 6 |
| ASAH1 | CLCA4 | 0.747016 | 10 | 0 | 10 |
| ASAH1 | GALNT12 | 0.746688 | 11 | 0 | 11 |
| ASAH1 | EMP1 | 0.745524 | 10 | 0 | 10 |
| ASAH1 | KAT2B | 0.744999 | 12 | 0 | 11 |
| ASAH1 | ST6GALNAC1 | 0.744708 | 7 | 0 | 7 |
| ASAH1 | CXCR2 | 0.744217 | 11 | 0 | 11 |
| ASAH1 | IMPACT | 0.742897 | 3 | 0 | 3 |
| ASAH1 | FAM214A | 0.741729 | 7 | 0 | 7 |
For details and further investigation, click here
