| Full name: A-kinase anchoring protein 8 like | Alias Symbol: NAKAP95|HAP95 | ||
| Type: protein-coding gene | Cytoband: 19p13.12 | ||
| Entrez ID: 26993 | HGNC ID: HGNC:29857 | Ensembl Gene: ENSG00000011243 | OMIM ID: 609475 |
| Drug and gene relationship at DGIdb | |||
Expression of AKAP8L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKAP8L | 26993 | 218064_s_at | 0.1747 | 0.7309 | |
| GSE20347 | AKAP8L | 26993 | 222160_at | 0.0722 | 0.5169 | |
| GSE23400 | AKAP8L | 26993 | 222160_at | -0.0999 | 0.0007 | |
| GSE26886 | AKAP8L | 26993 | 240554_at | -0.1279 | 0.5342 | |
| GSE29001 | AKAP8L | 26993 | 222160_at | 0.2234 | 0.3814 | |
| GSE38129 | AKAP8L | 26993 | 218064_s_at | 0.3597 | 0.0334 | |
| GSE45670 | AKAP8L | 26993 | 218064_s_at | 0.2942 | 0.0435 | |
| GSE53622 | AKAP8L | 26993 | 93318 | 0.1802 | 0.0065 | |
| GSE53624 | AKAP8L | 26993 | 93318 | 0.3051 | 0.0000 | |
| GSE63941 | AKAP8L | 26993 | 218064_s_at | 1.4774 | 0.0033 | |
| GSE77861 | AKAP8L | 26993 | 222160_at | 0.0614 | 0.5377 | |
| GSE97050 | AKAP8L | 26993 | A_23_P153767 | 0.2498 | 0.3164 | |
| SRP007169 | AKAP8L | 26993 | RNAseq | -0.1565 | 0.7204 | |
| SRP008496 | AKAP8L | 26993 | RNAseq | 0.1374 | 0.6550 | |
| SRP064894 | AKAP8L | 26993 | RNAseq | 0.7514 | 0.0036 | |
| SRP133303 | AKAP8L | 26993 | RNAseq | 0.0052 | 0.9617 | |
| SRP159526 | AKAP8L | 26993 | RNAseq | 0.2363 | 0.4254 | |
| SRP193095 | AKAP8L | 26993 | RNAseq | 0.4786 | 0.0006 | |
| SRP219564 | AKAP8L | 26993 | RNAseq | 0.5057 | 0.2466 | |
| TCGA | AKAP8L | 26993 | RNAseq | 0.0280 | 0.5847 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by AKAP8L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKAP8L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKAP8L | 26993 | 4 | 2 | 24 | |
| GSE20123 | AKAP8L | 26993 | 3 | 1 | 26 | |
| GSE43470 | AKAP8L | 26993 | 2 | 6 | 35 | |
| GSE46452 | AKAP8L | 26993 | 47 | 1 | 11 | |
| GSE47630 | AKAP8L | 26993 | 4 | 7 | 29 | |
| GSE54993 | AKAP8L | 26993 | 15 | 4 | 51 | |
| GSE54994 | AKAP8L | 26993 | 6 | 14 | 33 | |
| GSE60625 | AKAP8L | 26993 | 9 | 0 | 2 | |
| GSE74703 | AKAP8L | 26993 | 2 | 4 | 30 | |
| GSE74704 | AKAP8L | 26993 | 0 | 1 | 19 | |
| TCGA | AKAP8L | 26993 | 20 | 10 | 66 |
Total number of gains: 112; Total number of losses: 50; Total Number of normals: 326.
Somatic mutations of AKAP8L:
Generating mutation plots.
Highly correlated genes for AKAP8L:
Showing top 20/297 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKAP8L | STRN4 | 0.804008 | 3 | 0 | 3 |
| AKAP8L | GATAD2B | 0.795014 | 3 | 0 | 3 |
| AKAP8L | PLEKHH1 | 0.750854 | 3 | 0 | 3 |
| AKAP8L | NEK8 | 0.749178 | 3 | 0 | 3 |
| AKAP8L | ARF1 | 0.749077 | 3 | 0 | 3 |
| AKAP8L | ZNF584 | 0.747274 | 3 | 0 | 3 |
| AKAP8L | SFMBT1 | 0.745227 | 3 | 0 | 3 |
| AKAP8L | DIS3L2 | 0.743996 | 3 | 0 | 3 |
| AKAP8L | SLC25A38 | 0.739617 | 3 | 0 | 3 |
| AKAP8L | VAMP2 | 0.732025 | 3 | 0 | 3 |
| AKAP8L | KDM5A | 0.71358 | 3 | 0 | 3 |
| AKAP8L | ZNF706 | 0.711934 | 3 | 0 | 3 |
| AKAP8L | CHD7 | 0.703686 | 4 | 0 | 3 |
| AKAP8L | ALKBH6 | 0.69891 | 4 | 0 | 3 |
| AKAP8L | ANKRD12 | 0.694548 | 3 | 0 | 3 |
| AKAP8L | LENG8 | 0.693959 | 3 | 0 | 3 |
| AKAP8L | EXOC3L4 | 0.686516 | 4 | 0 | 4 |
| AKAP8L | NAP1L4 | 0.685414 | 3 | 0 | 3 |
| AKAP8L | OCIAD1 | 0.676086 | 3 | 0 | 3 |
| AKAP8L | GTPBP1 | 0.673625 | 3 | 0 | 3 |
For details and further investigation, click here
