| Full name: vesicle associated membrane protein 2 | Alias Symbol: VAMP-2 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 6844 | HGNC ID: HGNC:12643 | Ensembl Gene: ENSG00000220205 | OMIM ID: 185881 |
| Drug and gene relationship at DGIdb | |||
VAMP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04970 | Salivary secretion |
Expression of VAMP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VAMP2 | 6844 | 201556_s_at | -0.0814 | 0.8746 | |
| GSE20347 | VAMP2 | 6844 | 201557_at | -0.2773 | 0.0091 | |
| GSE23400 | VAMP2 | 6844 | 201557_at | -0.2696 | 0.0000 | |
| GSE26886 | VAMP2 | 6844 | 201557_at | 0.4833 | 0.0001 | |
| GSE29001 | VAMP2 | 6844 | 201556_s_at | -0.4125 | 0.1569 | |
| GSE38129 | VAMP2 | 6844 | 201557_at | -0.4958 | 0.0000 | |
| GSE45670 | VAMP2 | 6844 | 201557_at | -0.0731 | 0.4534 | |
| GSE53622 | VAMP2 | 6844 | 31502 | -0.6011 | 0.0000 | |
| GSE53624 | VAMP2 | 6844 | 31502 | -0.4173 | 0.0000 | |
| GSE63941 | VAMP2 | 6844 | 201556_s_at | 0.9051 | 0.0177 | |
| GSE77861 | VAMP2 | 6844 | 201557_at | -0.0372 | 0.8949 | |
| GSE97050 | VAMP2 | 6844 | A_33_P3213493 | -0.3120 | 0.3040 | |
| SRP007169 | VAMP2 | 6844 | RNAseq | -0.8368 | 0.0153 | |
| SRP008496 | VAMP2 | 6844 | RNAseq | -0.5758 | 0.0074 | |
| SRP064894 | VAMP2 | 6844 | RNAseq | -0.2363 | 0.2694 | |
| SRP133303 | VAMP2 | 6844 | RNAseq | -0.6542 | 0.0001 | |
| SRP159526 | VAMP2 | 6844 | RNAseq | -0.2223 | 0.3101 | |
| SRP193095 | VAMP2 | 6844 | RNAseq | -0.0966 | 0.4275 | |
| SRP219564 | VAMP2 | 6844 | RNAseq | 0.1253 | 0.7518 | |
| TCGA | VAMP2 | 6844 | RNAseq | -0.3085 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VAMP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VAMP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VAMP2 | 6844 | 4 | 2 | 24 | |
| GSE20123 | VAMP2 | 6844 | 4 | 3 | 23 | |
| GSE43470 | VAMP2 | 6844 | 1 | 6 | 36 | |
| GSE46452 | VAMP2 | 6844 | 34 | 1 | 24 | |
| GSE47630 | VAMP2 | 6844 | 7 | 1 | 32 | |
| GSE54993 | VAMP2 | 6844 | 4 | 3 | 63 | |
| GSE54994 | VAMP2 | 6844 | 5 | 8 | 40 | |
| GSE60625 | VAMP2 | 6844 | 4 | 0 | 7 | |
| GSE74703 | VAMP2 | 6844 | 1 | 3 | 32 | |
| GSE74704 | VAMP2 | 6844 | 2 | 1 | 17 | |
| TCGA | VAMP2 | 6844 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of VAMP2:
Generating mutation plots.
Highly correlated genes for VAMP2:
Showing top 20/502 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VAMP2 | PRR12 | 0.808573 | 3 | 0 | 3 |
| VAMP2 | PCGF2 | 0.777391 | 3 | 0 | 3 |
| VAMP2 | ZNF417 | 0.775392 | 3 | 0 | 3 |
| VAMP2 | BSN | 0.770618 | 5 | 0 | 4 |
| VAMP2 | INO80E | 0.770341 | 4 | 0 | 4 |
| VAMP2 | XRRA1 | 0.76464 | 3 | 0 | 3 |
| VAMP2 | AHSP | 0.754683 | 3 | 0 | 3 |
| VAMP2 | PDE3B | 0.749236 | 3 | 0 | 3 |
| VAMP2 | LINGO1 | 0.74614 | 3 | 0 | 3 |
| VAMP2 | TLN2 | 0.732534 | 3 | 0 | 3 |
| VAMP2 | AKAP8L | 0.732025 | 3 | 0 | 3 |
| VAMP2 | PXK | 0.728735 | 3 | 0 | 3 |
| VAMP2 | BCL7B | 0.727815 | 3 | 0 | 3 |
| VAMP2 | GDF5 | 0.725838 | 3 | 0 | 3 |
| VAMP2 | PPARA | 0.724976 | 3 | 0 | 3 |
| VAMP2 | MEIS3 | 0.722928 | 3 | 0 | 3 |
| VAMP2 | CAMTA2 | 0.722793 | 5 | 0 | 5 |
| VAMP2 | NFAM1 | 0.717579 | 3 | 0 | 3 |
| VAMP2 | SH3BP2 | 0.716125 | 3 | 0 | 3 |
| VAMP2 | CLDND2 | 0.715484 | 3 | 0 | 3 |
For details and further investigation, click here
