| Full name: aldo-keto reductase family 7 member A2 | Alias Symbol: AFAR | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 8574 | HGNC ID: HGNC:389 | Ensembl Gene: ENSG00000053371 | OMIM ID: 603418 |
| Drug and gene relationship at DGIdb | |||
Expression of AKR7A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKR7A2 | 8574 | 214259_s_at | -0.3314 | 0.6276 | |
| GSE20347 | AKR7A2 | 8574 | 214259_s_at | -0.6437 | 0.0002 | |
| GSE23400 | AKR7A2 | 8574 | 214259_s_at | -0.3803 | 0.0000 | |
| GSE26886 | AKR7A2 | 8574 | 214259_s_at | 0.0857 | 0.7562 | |
| GSE29001 | AKR7A2 | 8574 | 214259_s_at | -0.8038 | 0.0045 | |
| GSE38129 | AKR7A2 | 8574 | 214259_s_at | -0.4696 | 0.0001 | |
| GSE45670 | AKR7A2 | 8574 | 214259_s_at | -0.5234 | 0.0005 | |
| GSE53622 | AKR7A2 | 8574 | 30253 | -0.3998 | 0.0000 | |
| GSE53624 | AKR7A2 | 8574 | 30253 | -0.6859 | 0.0000 | |
| GSE63941 | AKR7A2 | 8574 | 214259_s_at | 0.2263 | 0.6453 | |
| GSE77861 | AKR7A2 | 8574 | 214259_s_at | -1.1408 | 0.0046 | |
| GSE97050 | AKR7A2 | 8574 | A_23_P115356 | 0.0079 | 0.9761 | |
| SRP007169 | AKR7A2 | 8574 | RNAseq | -1.7228 | 0.0001 | |
| SRP008496 | AKR7A2 | 8574 | RNAseq | -1.5279 | 0.0000 | |
| SRP064894 | AKR7A2 | 8574 | RNAseq | -0.1278 | 0.6477 | |
| SRP133303 | AKR7A2 | 8574 | RNAseq | -0.4003 | 0.0010 | |
| SRP159526 | AKR7A2 | 8574 | RNAseq | -0.3962 | 0.1168 | |
| SRP193095 | AKR7A2 | 8574 | RNAseq | -0.8402 | 0.0000 | |
| SRP219564 | AKR7A2 | 8574 | RNAseq | -0.7128 | 0.0042 | |
| TCGA | AKR7A2 | 8574 | RNAseq | -0.1095 | 0.0479 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by AKR7A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKR7A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKR7A2 | 8574 | 0 | 5 | 25 | |
| GSE20123 | AKR7A2 | 8574 | 0 | 4 | 26 | |
| GSE43470 | AKR7A2 | 8574 | 0 | 8 | 35 | |
| GSE46452 | AKR7A2 | 8574 | 5 | 1 | 53 | |
| GSE47630 | AKR7A2 | 8574 | 8 | 3 | 29 | |
| GSE54993 | AKR7A2 | 8574 | 3 | 1 | 66 | |
| GSE54994 | AKR7A2 | 8574 | 11 | 4 | 38 | |
| GSE60625 | AKR7A2 | 8574 | 0 | 0 | 11 | |
| GSE74703 | AKR7A2 | 8574 | 0 | 5 | 31 | |
| GSE74704 | AKR7A2 | 8574 | 0 | 0 | 20 | |
| TCGA | AKR7A2 | 8574 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of AKR7A2:
Generating mutation plots.
Highly correlated genes for AKR7A2:
Showing top 20/1007 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKR7A2 | SH2B1 | 0.7722 | 3 | 0 | 3 |
| AKR7A2 | WDFY1 | 0.771717 | 3 | 0 | 3 |
| AKR7A2 | RBPJL | 0.747326 | 3 | 0 | 3 |
| AKR7A2 | PITHD1 | 0.730558 | 6 | 0 | 6 |
| AKR7A2 | CDC14A | 0.717609 | 3 | 0 | 3 |
| AKR7A2 | SAMD8 | 0.711336 | 3 | 0 | 3 |
| AKR7A2 | SHB | 0.710954 | 3 | 0 | 3 |
| AKR7A2 | ZFAND2B | 0.707657 | 6 | 0 | 6 |
| AKR7A2 | ZNF626 | 0.707637 | 4 | 0 | 3 |
| AKR7A2 | SLC24A1 | 0.696026 | 3 | 0 | 3 |
| AKR7A2 | ATG2B | 0.694748 | 3 | 0 | 3 |
| AKR7A2 | ARSG | 0.694715 | 3 | 0 | 3 |
| AKR7A2 | GPR108 | 0.690978 | 3 | 0 | 3 |
| AKR7A2 | FMO4 | 0.690659 | 3 | 0 | 3 |
| AKR7A2 | VPS33A | 0.682207 | 3 | 0 | 3 |
| AKR7A2 | CNPPD1 | 0.682113 | 9 | 0 | 9 |
| AKR7A2 | BLOC1S1 | 0.68093 | 10 | 0 | 9 |
| AKR7A2 | TCEANC2 | 0.680443 | 4 | 0 | 3 |
| AKR7A2 | RPUSD3 | 0.678377 | 4 | 0 | 3 |
| AKR7A2 | KIF24 | 0.67652 | 3 | 0 | 3 |
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