| Full name: SH2 domain containing adaptor protein B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9p13.1 | ||
| Entrez ID: 6461 | HGNC ID: HGNC:10838 | Ensembl Gene: ENSG00000107338 | OMIM ID: 600314 |
| Drug and gene relationship at DGIdb | |||
Expression of SHB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHB | 6461 | 1557458_s_at | -0.1993 | 0.7268 | |
| GSE20347 | SHB | 6461 | 204656_at | -0.4722 | 0.0015 | |
| GSE23400 | SHB | 6461 | 204656_at | -0.1036 | 0.0505 | |
| GSE26886 | SHB | 6461 | 1557458_s_at | 0.2272 | 0.3330 | |
| GSE29001 | SHB | 6461 | 204656_at | -0.2808 | 0.1672 | |
| GSE38129 | SHB | 6461 | 204656_at | -0.2096 | 0.0955 | |
| GSE45670 | SHB | 6461 | 1557458_s_at | -0.1133 | 0.6174 | |
| GSE53622 | SHB | 6461 | 27519 | -0.1988 | 0.0290 | |
| GSE53624 | SHB | 6461 | 27519 | -0.2754 | 0.0012 | |
| GSE63941 | SHB | 6461 | 1557458_s_at | 0.0820 | 0.9167 | |
| GSE77861 | SHB | 6461 | 204657_s_at | -0.4024 | 0.0929 | |
| GSE97050 | SHB | 6461 | A_23_P257743 | 0.2506 | 0.4659 | |
| SRP007169 | SHB | 6461 | RNAseq | -1.1950 | 0.0115 | |
| SRP008496 | SHB | 6461 | RNAseq | -0.6599 | 0.0746 | |
| SRP064894 | SHB | 6461 | RNAseq | -0.4164 | 0.0627 | |
| SRP133303 | SHB | 6461 | RNAseq | -0.4037 | 0.2429 | |
| SRP159526 | SHB | 6461 | RNAseq | -0.3487 | 0.3783 | |
| SRP193095 | SHB | 6461 | RNAseq | -0.4490 | 0.0286 | |
| SRP219564 | SHB | 6461 | RNAseq | -0.5033 | 0.3290 | |
| TCGA | SHB | 6461 | RNAseq | 0.1105 | 0.0803 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SHB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHB | 6461 | 3 | 14 | 13 | |
| GSE20123 | SHB | 6461 | 3 | 14 | 13 | |
| GSE43470 | SHB | 6461 | 0 | 14 | 29 | |
| GSE46452 | SHB | 6461 | 6 | 15 | 38 | |
| GSE47630 | SHB | 6461 | 1 | 20 | 19 | |
| GSE54993 | SHB | 6461 | 6 | 0 | 64 | |
| GSE54994 | SHB | 6461 | 6 | 13 | 34 | |
| GSE60625 | SHB | 6461 | 0 | 0 | 11 | |
| GSE74703 | SHB | 6461 | 0 | 10 | 26 | |
| GSE74704 | SHB | 6461 | 0 | 10 | 10 | |
| TCGA | SHB | 6461 | 16 | 44 | 36 |
Total number of gains: 41; Total number of losses: 154; Total Number of normals: 293.
Somatic mutations of SHB:
Generating mutation plots.
Highly correlated genes for SHB:
Showing top 20/405 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHB | LY9 | 0.775397 | 3 | 0 | 3 |
| SHB | SUSD1 | 0.739718 | 3 | 0 | 3 |
| SHB | SNX15 | 0.734997 | 3 | 0 | 3 |
| SHB | CYP2C19 | 0.728664 | 3 | 0 | 3 |
| SHB | SCFD2 | 0.725378 | 3 | 0 | 3 |
| SHB | QPCTL | 0.725258 | 3 | 0 | 3 |
| SHB | MAPK11 | 0.722929 | 3 | 0 | 3 |
| SHB | HECW2 | 0.714245 | 3 | 0 | 3 |
| SHB | RNLS | 0.714186 | 3 | 0 | 3 |
| SHB | AKR7A2 | 0.710954 | 3 | 0 | 3 |
| SHB | CISH | 0.70534 | 3 | 0 | 3 |
| SHB | PLA2G2A | 0.702163 | 3 | 0 | 3 |
| SHB | DMBT1 | 0.69757 | 3 | 0 | 3 |
| SHB | FAM193B | 0.693782 | 3 | 0 | 3 |
| SHB | ACTR3C | 0.689146 | 3 | 0 | 3 |
| SHB | UTF1 | 0.682751 | 4 | 0 | 3 |
| SHB | OR2F1 | 0.681561 | 3 | 0 | 3 |
| SHB | CD3E | 0.679163 | 3 | 0 | 3 |
| SHB | ATP6V1C2 | 0.677693 | 3 | 0 | 3 |
| SHB | CLDN11 | 0.672657 | 3 | 0 | 3 |
For details and further investigation, click here
