| Full name: aldehyde dehydrogenase 18 family member A1 | Alias Symbol: P5CS | ||
| Type: protein-coding gene | Cytoband: 10q24.1 | ||
| Entrez ID: 5832 | HGNC ID: HGNC:9722 | Ensembl Gene: ENSG00000059573 | OMIM ID: 138250 |
| Drug and gene relationship at DGIdb | |||
Expression of ALDH18A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH18A1 | 5832 | 222416_at | 0.4901 | 0.3398 | |
| GSE20347 | ALDH18A1 | 5832 | 217791_s_at | 0.0386 | 0.8564 | |
| GSE23400 | ALDH18A1 | 5832 | 217791_s_at | 0.2998 | 0.0000 | |
| GSE26886 | ALDH18A1 | 5832 | 222416_at | 0.5619 | 0.0211 | |
| GSE29001 | ALDH18A1 | 5832 | 217791_s_at | 0.2162 | 0.4828 | |
| GSE38129 | ALDH18A1 | 5832 | 217791_s_at | 0.3576 | 0.0266 | |
| GSE45670 | ALDH18A1 | 5832 | 222416_at | 0.2828 | 0.0434 | |
| GSE53622 | ALDH18A1 | 5832 | 4008 | 0.3783 | 0.0000 | |
| GSE53624 | ALDH18A1 | 5832 | 4008 | 0.3185 | 0.0001 | |
| GSE63941 | ALDH18A1 | 5832 | 222416_at | -0.3585 | 0.2380 | |
| GSE77861 | ALDH18A1 | 5832 | 217791_s_at | -0.0184 | 0.9532 | |
| GSE97050 | ALDH18A1 | 5832 | A_23_P1361 | 0.7076 | 0.1294 | |
| SRP007169 | ALDH18A1 | 5832 | RNAseq | 0.3887 | 0.2498 | |
| SRP008496 | ALDH18A1 | 5832 | RNAseq | 0.6767 | 0.0042 | |
| SRP064894 | ALDH18A1 | 5832 | RNAseq | 0.0915 | 0.5652 | |
| SRP133303 | ALDH18A1 | 5832 | RNAseq | 0.2389 | 0.0561 | |
| SRP159526 | ALDH18A1 | 5832 | RNAseq | 0.3524 | 0.0247 | |
| SRP193095 | ALDH18A1 | 5832 | RNAseq | -0.2769 | 0.1195 | |
| SRP219564 | ALDH18A1 | 5832 | RNAseq | 0.4290 | 0.1471 | |
| TCGA | ALDH18A1 | 5832 | RNAseq | -0.0809 | 0.0769 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALDH18A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH18A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH18A1 | 5832 | 0 | 8 | 22 | |
| GSE20123 | ALDH18A1 | 5832 | 0 | 7 | 23 | |
| GSE43470 | ALDH18A1 | 5832 | 0 | 7 | 36 | |
| GSE46452 | ALDH18A1 | 5832 | 0 | 11 | 48 | |
| GSE47630 | ALDH18A1 | 5832 | 2 | 14 | 24 | |
| GSE54993 | ALDH18A1 | 5832 | 7 | 0 | 63 | |
| GSE54994 | ALDH18A1 | 5832 | 2 | 10 | 41 | |
| GSE60625 | ALDH18A1 | 5832 | 0 | 0 | 11 | |
| GSE74703 | ALDH18A1 | 5832 | 0 | 5 | 31 | |
| GSE74704 | ALDH18A1 | 5832 | 0 | 4 | 16 | |
| TCGA | ALDH18A1 | 5832 | 6 | 27 | 63 |
Total number of gains: 17; Total number of losses: 93; Total Number of normals: 378.
Somatic mutations of ALDH18A1:
Generating mutation plots.
Highly correlated genes for ALDH18A1:
Showing top 20/916 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH18A1 | ACBD5 | 0.811376 | 3 | 0 | 3 |
| ALDH18A1 | TCF19 | 0.769026 | 3 | 0 | 3 |
| ALDH18A1 | CEP350 | 0.749277 | 3 | 0 | 3 |
| ALDH18A1 | CLIC1 | 0.748326 | 3 | 0 | 3 |
| ALDH18A1 | KTI12 | 0.741512 | 3 | 0 | 3 |
| ALDH18A1 | SMARCAD1 | 0.735709 | 4 | 0 | 4 |
| ALDH18A1 | ZNF764 | 0.731134 | 3 | 0 | 3 |
| ALDH18A1 | SUFU | 0.729747 | 3 | 0 | 3 |
| ALDH18A1 | TMTC3 | 0.717686 | 3 | 0 | 3 |
| ALDH18A1 | PHF20 | 0.713769 | 3 | 0 | 3 |
| ALDH18A1 | SFT2D3 | 0.712864 | 3 | 0 | 3 |
| ALDH18A1 | KRTCAP2 | 0.709877 | 3 | 0 | 3 |
| ALDH18A1 | SLC30A7 | 0.707231 | 4 | 0 | 4 |
| ALDH18A1 | DHRS13 | 0.705146 | 3 | 0 | 3 |
| ALDH18A1 | TM2D2 | 0.698717 | 4 | 0 | 3 |
| ALDH18A1 | ZNF700 | 0.690881 | 3 | 0 | 3 |
| ALDH18A1 | ERCC6 | 0.69033 | 4 | 0 | 4 |
| ALDH18A1 | ALG10 | 0.689261 | 4 | 0 | 4 |
| ALDH18A1 | UPF1 | 0.68727 | 3 | 0 | 3 |
| ALDH18A1 | ACAP2 | 0.687089 | 3 | 0 | 3 |
For details and further investigation, click here
