| Full name: TM2 domain containing 2 | Alias Symbol: BLP1 | ||
| Type: protein-coding gene | Cytoband: 8p11.22 | ||
| Entrez ID: 83877 | HGNC ID: HGNC:24127 | Ensembl Gene: ENSG00000169490 | OMIM ID: 610081 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TM2D2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TM2D2 | 83877 | 224413_s_at | 0.5402 | 0.2359 | |
| GSE26886 | TM2D2 | 83877 | 224413_s_at | -0.3503 | 0.1709 | |
| GSE45670 | TM2D2 | 83877 | 224413_s_at | 0.4891 | 0.0030 | |
| GSE53622 | TM2D2 | 83877 | 76568 | 0.5807 | 0.0000 | |
| GSE53624 | TM2D2 | 83877 | 76568 | 0.5423 | 0.0000 | |
| GSE63941 | TM2D2 | 83877 | 224413_s_at | -1.2328 | 0.0163 | |
| GSE77861 | TM2D2 | 83877 | 224413_s_at | 0.4545 | 0.0881 | |
| GSE97050 | TM2D2 | 83877 | A_23_P502678 | 0.5852 | 0.1949 | |
| SRP007169 | TM2D2 | 83877 | RNAseq | 0.0213 | 0.9620 | |
| SRP008496 | TM2D2 | 83877 | RNAseq | 0.2286 | 0.3684 | |
| SRP064894 | TM2D2 | 83877 | RNAseq | 0.2495 | 0.1911 | |
| SRP133303 | TM2D2 | 83877 | RNAseq | 0.7886 | 0.0000 | |
| SRP159526 | TM2D2 | 83877 | RNAseq | 0.3995 | 0.0631 | |
| SRP193095 | TM2D2 | 83877 | RNAseq | 0.2076 | 0.2481 | |
| SRP219564 | TM2D2 | 83877 | RNAseq | 0.4830 | 0.1669 | |
| TCGA | TM2D2 | 83877 | RNAseq | 0.0517 | 0.3540 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TM2D2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TM2D2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TM2D2 | 83877 | 10 | 4 | 16 | |
| GSE20123 | TM2D2 | 83877 | 10 | 4 | 16 | |
| GSE43470 | TM2D2 | 83877 | 8 | 6 | 29 | |
| GSE46452 | TM2D2 | 83877 | 20 | 5 | 34 | |
| GSE47630 | TM2D2 | 83877 | 12 | 7 | 21 | |
| GSE54993 | TM2D2 | 83877 | 2 | 16 | 52 | |
| GSE54994 | TM2D2 | 83877 | 16 | 7 | 30 | |
| GSE60625 | TM2D2 | 83877 | 3 | 0 | 8 | |
| GSE74703 | TM2D2 | 83877 | 8 | 5 | 23 | |
| GSE74704 | TM2D2 | 83877 | 9 | 1 | 10 | |
| TCGA | TM2D2 | 83877 | 35 | 23 | 38 |
Total number of gains: 133; Total number of losses: 78; Total Number of normals: 277.
Somatic mutations of TM2D2:
Generating mutation plots.
Highly correlated genes for TM2D2:
Showing top 20/717 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TM2D2 | CDK2AP1 | 0.857691 | 3 | 0 | 3 |
| TM2D2 | RPRD1B | 0.813572 | 3 | 0 | 3 |
| TM2D2 | NECAP2 | 0.784102 | 3 | 0 | 3 |
| TM2D2 | CDV3 | 0.780559 | 3 | 0 | 3 |
| TM2D2 | SLC7A6 | 0.758705 | 3 | 0 | 3 |
| TM2D2 | USP38 | 0.75816 | 3 | 0 | 3 |
| TM2D2 | RAP1GDS1 | 0.753817 | 3 | 0 | 3 |
| TM2D2 | SMC3 | 0.749601 | 4 | 0 | 4 |
| TM2D2 | CLDN12 | 0.74827 | 4 | 0 | 4 |
| TM2D2 | PCTP | 0.747656 | 3 | 0 | 3 |
| TM2D2 | RBM39 | 0.7434 | 3 | 0 | 3 |
| TM2D2 | XPNPEP1 | 0.742388 | 3 | 0 | 3 |
| TM2D2 | CMTM6 | 0.73999 | 3 | 0 | 3 |
| TM2D2 | CDCA2 | 0.737237 | 4 | 0 | 4 |
| TM2D2 | MGAT5 | 0.736126 | 3 | 0 | 3 |
| TM2D2 | ADAM9 | 0.734619 | 6 | 0 | 6 |
| TM2D2 | CENPBD1 | 0.732431 | 3 | 0 | 3 |
| TM2D2 | RAD18 | 0.728706 | 3 | 0 | 3 |
| TM2D2 | DNPEP | 0.725347 | 3 | 0 | 3 |
| TM2D2 | RAD21 | 0.725163 | 3 | 0 | 3 |
For details and further investigation, click here
