| Full name: aldehyde dehydrogenase 2 family member | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q24.12 | ||
| Entrez ID: 217 | HGNC ID: HGNC:404 | Ensembl Gene: ENSG00000111275 | OMIM ID: 100650 |
| Drug and gene relationship at DGIdb | |||
Expression of ALDH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH2 | 217 | 201425_at | -0.1313 | 0.8277 | |
| GSE20347 | ALDH2 | 217 | 201425_at | -1.0588 | 0.0000 | |
| GSE23400 | ALDH2 | 217 | 201425_at | -0.6808 | 0.0000 | |
| GSE26886 | ALDH2 | 217 | 201425_at | -1.3500 | 0.0008 | |
| GSE29001 | ALDH2 | 217 | 201425_at | -0.8152 | 0.0480 | |
| GSE38129 | ALDH2 | 217 | 201425_at | -1.1691 | 0.0000 | |
| GSE45670 | ALDH2 | 217 | 201425_at | -0.7923 | 0.0004 | |
| GSE53622 | ALDH2 | 217 | 67472 | -1.0453 | 0.0000 | |
| GSE53624 | ALDH2 | 217 | 67472 | -1.2156 | 0.0000 | |
| GSE63941 | ALDH2 | 217 | 201425_at | -2.6903 | 0.0697 | |
| GSE77861 | ALDH2 | 217 | 201425_at | -1.0603 | 0.0464 | |
| GSE97050 | ALDH2 | 217 | A_23_P36753 | -0.8629 | 0.1608 | |
| SRP007169 | ALDH2 | 217 | RNAseq | -1.9333 | 0.0000 | |
| SRP008496 | ALDH2 | 217 | RNAseq | -1.7799 | 0.0000 | |
| SRP064894 | ALDH2 | 217 | RNAseq | -0.9397 | 0.0000 | |
| SRP133303 | ALDH2 | 217 | RNAseq | -0.7625 | 0.0000 | |
| SRP159526 | ALDH2 | 217 | RNAseq | -1.1750 | 0.0000 | |
| SRP193095 | ALDH2 | 217 | RNAseq | -0.7394 | 0.0000 | |
| SRP219564 | ALDH2 | 217 | RNAseq | -1.1340 | 0.0255 | |
| TCGA | ALDH2 | 217 | RNAseq | -0.4303 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by ALDH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH2 | 217 | 5 | 3 | 22 | |
| GSE20123 | ALDH2 | 217 | 5 | 3 | 22 | |
| GSE43470 | ALDH2 | 217 | 2 | 1 | 40 | |
| GSE46452 | ALDH2 | 217 | 9 | 1 | 49 | |
| GSE47630 | ALDH2 | 217 | 9 | 3 | 28 | |
| GSE54993 | ALDH2 | 217 | 0 | 5 | 65 | |
| GSE54994 | ALDH2 | 217 | 4 | 2 | 47 | |
| GSE60625 | ALDH2 | 217 | 0 | 0 | 11 | |
| GSE74703 | ALDH2 | 217 | 2 | 0 | 34 | |
| GSE74704 | ALDH2 | 217 | 2 | 2 | 16 | |
| TCGA | ALDH2 | 217 | 22 | 11 | 63 |
Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.
Somatic mutations of ALDH2:
Generating mutation plots.
Highly correlated genes for ALDH2:
Showing top 20/890 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH2 | FYTTD1 | 0.781869 | 3 | 0 | 3 |
| ALDH2 | UQCRC2 | 0.763789 | 3 | 0 | 3 |
| ALDH2 | CSNK1A1 | 0.743149 | 4 | 0 | 4 |
| ALDH2 | TPD52L2 | 0.732944 | 3 | 0 | 3 |
| ALDH2 | FBXW5 | 0.731212 | 4 | 0 | 4 |
| ALDH2 | NFIA | 0.71708 | 6 | 0 | 6 |
| ALDH2 | CLEC3B | 0.702151 | 3 | 0 | 3 |
| ALDH2 | GPSM2 | 0.694795 | 5 | 0 | 5 |
| ALDH2 | NSFL1C | 0.690177 | 3 | 0 | 3 |
| ALDH2 | GRHPR | 0.688479 | 4 | 0 | 4 |
| ALDH2 | PPP1R3D | 0.685002 | 3 | 0 | 3 |
| ALDH2 | RIOK2 | 0.676913 | 3 | 0 | 3 |
| ALDH2 | C1QTNF7 | 0.675341 | 4 | 0 | 4 |
| ALDH2 | FCER1A | 0.674751 | 9 | 0 | 8 |
| ALDH2 | SORCS1 | 0.674477 | 3 | 0 | 3 |
| ALDH2 | MPP7 | 0.673682 | 6 | 0 | 5 |
| ALDH2 | ATP6V1H | 0.672478 | 4 | 0 | 3 |
| ALDH2 | ZNF547 | 0.671925 | 3 | 0 | 3 |
| ALDH2 | SETD2 | 0.67133 | 4 | 0 | 4 |
| ALDH2 | XKR4 | 0.671172 | 4 | 0 | 3 |
For details and further investigation, click here
