| Full name: Fc fragment of IgE receptor Ia | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q23.2 | ||
| Entrez ID: 2205 | HGNC ID: HGNC:3609 | Ensembl Gene: ENSG00000179639 | OMIM ID: 147140 |
| Drug and gene relationship at DGIdb | |||
FCER1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04071 | Sphingolipid signaling pathway | |
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04664 | Fc epsilon RI signaling pathway |
Expression of FCER1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FCER1A | 2205 | 211734_s_at | -2.8214 | 0.0523 | |
| GSE20347 | FCER1A | 2205 | 211734_s_at | -2.7237 | 0.0000 | |
| GSE23400 | FCER1A | 2205 | 211734_s_at | -0.6805 | 0.0000 | |
| GSE26886 | FCER1A | 2205 | 211734_s_at | -3.0359 | 0.0000 | |
| GSE29001 | FCER1A | 2205 | 211734_s_at | -2.1138 | 0.0000 | |
| GSE38129 | FCER1A | 2205 | 211734_s_at | -2.5825 | 0.0000 | |
| GSE45670 | FCER1A | 2205 | 211734_s_at | -2.7823 | 0.0001 | |
| GSE53622 | FCER1A | 2205 | 18390 | -3.3925 | 0.0000 | |
| GSE53624 | FCER1A | 2205 | 18390 | -3.9001 | 0.0000 | |
| GSE63941 | FCER1A | 2205 | 1562537_at | 0.2007 | 0.0950 | |
| GSE77861 | FCER1A | 2205 | 1562537_at | 0.0107 | 0.9419 | |
| GSE97050 | FCER1A | 2205 | A_23_P103765 | -1.2565 | 0.1143 | |
| SRP007169 | FCER1A | 2205 | RNAseq | -4.8818 | 0.0000 | |
| SRP064894 | FCER1A | 2205 | RNAseq | -2.4127 | 0.0000 | |
| SRP133303 | FCER1A | 2205 | RNAseq | -3.6935 | 0.0000 | |
| SRP159526 | FCER1A | 2205 | RNAseq | -3.7577 | 0.0000 | |
| SRP219564 | FCER1A | 2205 | RNAseq | -3.0054 | 0.0001 | |
| TCGA | FCER1A | 2205 | RNAseq | -0.7146 | 0.1092 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by FCER1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FCER1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FCER1A | 2205 | 10 | 0 | 20 | |
| GSE20123 | FCER1A | 2205 | 10 | 0 | 20 | |
| GSE43470 | FCER1A | 2205 | 7 | 2 | 34 | |
| GSE46452 | FCER1A | 2205 | 2 | 1 | 56 | |
| GSE47630 | FCER1A | 2205 | 14 | 0 | 26 | |
| GSE54993 | FCER1A | 2205 | 0 | 5 | 65 | |
| GSE54994 | FCER1A | 2205 | 16 | 0 | 37 | |
| GSE60625 | FCER1A | 2205 | 0 | 0 | 11 | |
| GSE74703 | FCER1A | 2205 | 7 | 2 | 27 | |
| GSE74704 | FCER1A | 2205 | 4 | 0 | 16 | |
| TCGA | FCER1A | 2205 | 42 | 3 | 51 |
Total number of gains: 112; Total number of losses: 13; Total Number of normals: 363.
Somatic mutations of FCER1A:
Generating mutation plots.
Highly correlated genes for FCER1A:
Showing top 20/1596 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FCER1A | HPGD | 0.836437 | 10 | 0 | 10 |
| FCER1A | CD207 | 0.817314 | 9 | 0 | 9 |
| FCER1A | SH3BGRL2 | 0.816862 | 6 | 0 | 6 |
| FCER1A | CCDC7 | 0.812535 | 3 | 0 | 3 |
| FCER1A | TFAP2B | 0.805785 | 8 | 0 | 8 |
| FCER1A | FAM214A | 0.804488 | 5 | 0 | 5 |
| FCER1A | BRK1 | 0.801316 | 6 | 0 | 6 |
| FCER1A | CCNG2 | 0.80117 | 10 | 0 | 10 |
| FCER1A | CA13 | 0.800487 | 3 | 0 | 3 |
| FCER1A | KAT2B | 0.799668 | 10 | 0 | 10 |
| FCER1A | NAGK | 0.79845 | 10 | 0 | 10 |
| FCER1A | UBL3 | 0.795597 | 10 | 0 | 9 |
| FCER1A | EPB41L3 | 0.79469 | 10 | 0 | 10 |
| FCER1A | KIAA1211L | 0.793336 | 5 | 0 | 5 |
| FCER1A | PAIP2B | 0.792861 | 10 | 0 | 10 |
| FCER1A | SLC16A6 | 0.79029 | 10 | 0 | 10 |
| FCER1A | ETFDH | 0.788756 | 9 | 0 | 9 |
| FCER1A | CTTNBP2 | 0.787707 | 5 | 0 | 5 |
| FCER1A | SPINK7 | 0.78745 | 5 | 0 | 5 |
| FCER1A | NUCB2 | 0.786235 | 10 | 0 | 10 |
For details and further investigation, click here
