| Full name: ubiquinol-cytochrome c reductase core protein 2 | Alias Symbol: QCR2|UQCR2 | ||
| Type: protein-coding gene | Cytoband: 16p12.2 | ||
| Entrez ID: 7385 | HGNC ID: HGNC:12586 | Ensembl Gene: ENSG00000140740 | OMIM ID: 191329 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UQCRC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UQCRC2 | 7385 | 212600_s_at | -0.3926 | 0.2061 | |
| GSE20347 | UQCRC2 | 7385 | 212600_s_at | -0.1245 | 0.3192 | |
| GSE23400 | UQCRC2 | 7385 | 212600_s_at | -0.0125 | 0.8756 | |
| GSE26886 | UQCRC2 | 7385 | 212600_s_at | -0.8267 | 0.0000 | |
| GSE29001 | UQCRC2 | 7385 | 212600_s_at | -0.0432 | 0.9094 | |
| GSE38129 | UQCRC2 | 7385 | 212600_s_at | -0.2258 | 0.0202 | |
| GSE45670 | UQCRC2 | 7385 | 212600_s_at | -0.1433 | 0.1904 | |
| GSE53622 | UQCRC2 | 7385 | 102130 | -0.6466 | 0.0000 | |
| GSE53624 | UQCRC2 | 7385 | 102130 | -0.1501 | 0.0093 | |
| GSE63941 | UQCRC2 | 7385 | 212600_s_at | 0.4924 | 0.0512 | |
| GSE77861 | UQCRC2 | 7385 | 212600_s_at | -0.4022 | 0.2912 | |
| GSE97050 | UQCRC2 | 7385 | A_23_P118002 | -0.5029 | 0.1922 | |
| SRP007169 | UQCRC2 | 7385 | RNAseq | -0.6886 | 0.0500 | |
| SRP008496 | UQCRC2 | 7385 | RNAseq | -0.9260 | 0.0000 | |
| SRP064894 | UQCRC2 | 7385 | RNAseq | -0.6071 | 0.0000 | |
| SRP133303 | UQCRC2 | 7385 | RNAseq | -0.1554 | 0.3228 | |
| SRP159526 | UQCRC2 | 7385 | RNAseq | -0.2332 | 0.4630 | |
| SRP193095 | UQCRC2 | 7385 | RNAseq | -0.7132 | 0.0000 | |
| SRP219564 | UQCRC2 | 7385 | RNAseq | -0.7762 | 0.0322 | |
| TCGA | UQCRC2 | 7385 | RNAseq | -0.1720 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UQCRC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UQCRC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UQCRC2 | 7385 | 6 | 3 | 21 | |
| GSE20123 | UQCRC2 | 7385 | 6 | 2 | 22 | |
| GSE43470 | UQCRC2 | 7385 | 3 | 3 | 37 | |
| GSE46452 | UQCRC2 | 7385 | 38 | 1 | 20 | |
| GSE47630 | UQCRC2 | 7385 | 11 | 6 | 23 | |
| GSE54993 | UQCRC2 | 7385 | 3 | 5 | 62 | |
| GSE54994 | UQCRC2 | 7385 | 3 | 10 | 40 | |
| GSE60625 | UQCRC2 | 7385 | 4 | 0 | 7 | |
| GSE74703 | UQCRC2 | 7385 | 3 | 2 | 31 | |
| GSE74704 | UQCRC2 | 7385 | 3 | 1 | 16 | |
| TCGA | UQCRC2 | 7385 | 19 | 13 | 64 |
Total number of gains: 99; Total number of losses: 46; Total Number of normals: 343.
Somatic mutations of UQCRC2:
Generating mutation plots.
Highly correlated genes for UQCRC2:
Showing top 20/821 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UQCRC2 | SLC12A6 | 0.8159 | 3 | 0 | 3 |
| UQCRC2 | CBR4 | 0.794302 | 3 | 0 | 3 |
| UQCRC2 | WASF2 | 0.773253 | 3 | 0 | 3 |
| UQCRC2 | OSBPL2 | 0.766536 | 4 | 0 | 4 |
| UQCRC2 | ALDH2 | 0.763789 | 3 | 0 | 3 |
| UQCRC2 | RASSF3 | 0.748105 | 3 | 0 | 3 |
| UQCRC2 | HIPK1 | 0.74604 | 4 | 0 | 4 |
| UQCRC2 | CERS3 | 0.740424 | 3 | 0 | 3 |
| UQCRC2 | HBP1 | 0.729541 | 4 | 0 | 4 |
| UQCRC2 | HIGD1A | 0.724449 | 6 | 0 | 5 |
| UQCRC2 | NAA20 | 0.717312 | 3 | 0 | 3 |
| UQCRC2 | CHMP4B | 0.71689 | 4 | 0 | 4 |
| UQCRC2 | FRA10AC1 | 0.716148 | 3 | 0 | 3 |
| UQCRC2 | NCOA4 | 0.711981 | 7 | 0 | 5 |
| UQCRC2 | AP1AR | 0.711756 | 3 | 0 | 3 |
| UQCRC2 | AHNAK | 0.708115 | 3 | 0 | 3 |
| UQCRC2 | FASTKD2 | 0.707269 | 3 | 0 | 3 |
| UQCRC2 | ZNF175 | 0.701351 | 3 | 0 | 3 |
| UQCRC2 | PPP2CA | 0.699746 | 5 | 0 | 5 |
| UQCRC2 | MAL | 0.696282 | 4 | 0 | 4 |
For details and further investigation, click here
