| Full name: aldolase, fructose-bisphosphate A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 226 | HGNC ID: HGNC:414 | Ensembl Gene: ENSG00000149925 | OMIM ID: 103850 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ALDOA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway |
Expression of ALDOA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDOA | 226 | 214687_x_at | -0.1771 | 0.6860 | |
| GSE20347 | ALDOA | 226 | 214687_x_at | -0.3161 | 0.0029 | |
| GSE23400 | ALDOA | 226 | 200966_x_at | -0.0874 | 0.1358 | |
| GSE26886 | ALDOA | 226 | 214687_x_at | -0.5112 | 0.0011 | |
| GSE29001 | ALDOA | 226 | 214687_x_at | -0.3565 | 0.2462 | |
| GSE38129 | ALDOA | 226 | 214687_x_at | -0.1263 | 0.3571 | |
| GSE45670 | ALDOA | 226 | 214687_x_at | 0.1592 | 0.2801 | |
| GSE53622 | ALDOA | 226 | 31350 | -0.0235 | 0.8052 | |
| GSE53624 | ALDOA | 226 | 31350 | 0.3105 | 0.0000 | |
| GSE63941 | ALDOA | 226 | 200966_x_at | 0.6826 | 0.0346 | |
| GSE77861 | ALDOA | 226 | 214687_x_at | -0.1086 | 0.6847 | |
| GSE97050 | ALDOA | 226 | A_23_P88963 | -0.1024 | 0.7357 | |
| SRP007169 | ALDOA | 226 | RNAseq | -1.2795 | 0.0000 | |
| SRP008496 | ALDOA | 226 | RNAseq | -1.3618 | 0.0000 | |
| SRP064894 | ALDOA | 226 | RNAseq | -0.3890 | 0.1343 | |
| SRP133303 | ALDOA | 226 | RNAseq | 0.1891 | 0.3363 | |
| SRP159526 | ALDOA | 226 | RNAseq | -0.3242 | 0.3816 | |
| SRP193095 | ALDOA | 226 | RNAseq | -0.3808 | 0.0183 | |
| SRP219564 | ALDOA | 226 | RNAseq | -0.3237 | 0.2822 | |
| TCGA | ALDOA | 226 | RNAseq | 0.1115 | 0.0175 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ALDOA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDOA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDOA | 226 | 5 | 5 | 20 | |
| GSE20123 | ALDOA | 226 | 5 | 4 | 21 | |
| GSE43470 | ALDOA | 226 | 3 | 3 | 37 | |
| GSE46452 | ALDOA | 226 | 38 | 1 | 20 | |
| GSE47630 | ALDOA | 226 | 11 | 7 | 22 | |
| GSE54993 | ALDOA | 226 | 3 | 5 | 62 | |
| GSE54994 | ALDOA | 226 | 5 | 9 | 39 | |
| GSE60625 | ALDOA | 226 | 4 | 0 | 7 | |
| GSE74703 | ALDOA | 226 | 3 | 2 | 31 | |
| GSE74704 | ALDOA | 226 | 3 | 2 | 15 | |
| TCGA | ALDOA | 226 | 20 | 11 | 65 |
Total number of gains: 100; Total number of losses: 49; Total Number of normals: 339.
Somatic mutations of ALDOA:
Generating mutation plots.
Highly correlated genes for ALDOA:
Showing top 20/585 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDOA | THAP2 | 0.796556 | 3 | 0 | 3 |
| ALDOA | MFF | 0.791974 | 3 | 0 | 3 |
| ALDOA | ERI2 | 0.755818 | 3 | 0 | 3 |
| ALDOA | FASTKD2 | 0.752502 | 3 | 0 | 3 |
| ALDOA | ZFC3H1 | 0.734812 | 3 | 0 | 3 |
| ALDOA | HSDL2 | 0.731559 | 3 | 0 | 3 |
| ALDOA | CCNYL1 | 0.729615 | 3 | 0 | 3 |
| ALDOA | PALMD | 0.720854 | 5 | 0 | 5 |
| ALDOA | TINF2 | 0.720628 | 3 | 0 | 3 |
| ALDOA | TMEM59 | 0.719575 | 4 | 0 | 4 |
| ALDOA | KCTD2 | 0.709741 | 3 | 0 | 3 |
| ALDOA | TWF2 | 0.706855 | 5 | 0 | 5 |
| ALDOA | RLF | 0.702775 | 3 | 0 | 3 |
| ALDOA | STAU2 | 0.694893 | 4 | 0 | 4 |
| ALDOA | NSA2 | 0.690457 | 3 | 0 | 3 |
| ALDOA | RHBDD1 | 0.688952 | 3 | 0 | 3 |
| ALDOA | ZNF213 | 0.688498 | 4 | 0 | 4 |
| ALDOA | RAB7A | 0.688035 | 3 | 0 | 3 |
| ALDOA | BCKDK | 0.687519 | 8 | 0 | 8 |
| ALDOA | USP3 | 0.686271 | 3 | 0 | 3 |
For details and further investigation, click here
