| Full name: RAB7A, member RAS oncogene family | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q21.3 | ||
| Entrez ID: 7879 | HGNC ID: HGNC:9788 | Ensembl Gene: ENSG00000075785 | OMIM ID: 602298 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RAB7A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05152 | Tuberculosis |
Expression of RAB7A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAB7A | 7879 | 211961_s_at | 0.2816 | 0.3317 | |
| GSE20347 | RAB7A | 7879 | 211961_s_at | 0.0697 | 0.5107 | |
| GSE23400 | RAB7A | 7879 | 211961_s_at | 0.1915 | 0.0036 | |
| GSE26886 | RAB7A | 7879 | 211961_s_at | -0.4429 | 0.0173 | |
| GSE29001 | RAB7A | 7879 | 211961_s_at | 0.1048 | 0.7596 | |
| GSE38129 | RAB7A | 7879 | 211961_s_at | 0.0728 | 0.4354 | |
| GSE45670 | RAB7A | 7879 | 211960_s_at | 0.2696 | 0.0579 | |
| GSE53622 | RAB7A | 7879 | 7545 | -0.1678 | 0.0021 | |
| GSE53624 | RAB7A | 7879 | 7545 | 0.0609 | 0.3556 | |
| GSE63941 | RAB7A | 7879 | 211961_s_at | -0.0014 | 0.9974 | |
| GSE77861 | RAB7A | 7879 | 211961_s_at | 0.1876 | 0.4520 | |
| GSE97050 | RAB7A | 7879 | A_33_P3361851 | -0.1471 | 0.5294 | |
| SRP007169 | RAB7A | 7879 | RNAseq | -0.8149 | 0.0360 | |
| SRP008496 | RAB7A | 7879 | RNAseq | -0.5848 | 0.0149 | |
| SRP064894 | RAB7A | 7879 | RNAseq | 0.0474 | 0.7751 | |
| SRP133303 | RAB7A | 7879 | RNAseq | 0.3376 | 0.0914 | |
| SRP159526 | RAB7A | 7879 | RNAseq | -0.1645 | 0.5864 | |
| SRP193095 | RAB7A | 7879 | RNAseq | -0.1623 | 0.3301 | |
| SRP219564 | RAB7A | 7879 | RNAseq | -0.1599 | 0.5419 | |
| TCGA | RAB7A | 7879 | RNAseq | 0.1418 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RAB7A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAB7A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAB7A | 7879 | 17 | 0 | 13 | |
| GSE20123 | RAB7A | 7879 | 17 | 0 | 13 | |
| GSE43470 | RAB7A | 7879 | 19 | 0 | 24 | |
| GSE46452 | RAB7A | 7879 | 14 | 5 | 40 | |
| GSE47630 | RAB7A | 7879 | 18 | 3 | 19 | |
| GSE54993 | RAB7A | 7879 | 2 | 7 | 61 | |
| GSE54994 | RAB7A | 7879 | 31 | 3 | 19 | |
| GSE60625 | RAB7A | 7879 | 0 | 6 | 5 | |
| GSE74703 | RAB7A | 7879 | 17 | 0 | 19 | |
| GSE74704 | RAB7A | 7879 | 13 | 0 | 7 | |
| TCGA | RAB7A | 7879 | 58 | 5 | 33 |
Total number of gains: 206; Total number of losses: 29; Total Number of normals: 253.
Somatic mutations of RAB7A:
Generating mutation plots.
Highly correlated genes for RAB7A:
Showing top 20/282 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAB7A | RAB1B | 0.825446 | 3 | 0 | 3 |
| RAB7A | BANF1 | 0.814095 | 3 | 0 | 3 |
| RAB7A | PRKCSH | 0.798985 | 3 | 0 | 3 |
| RAB7A | ARID1A | 0.79789 | 3 | 0 | 3 |
| RAB7A | ARHGEF11 | 0.786513 | 3 | 0 | 3 |
| RAB7A | FAM89B | 0.776231 | 3 | 0 | 3 |
| RAB7A | RUNDC1 | 0.774842 | 3 | 0 | 3 |
| RAB7A | ANKRD54 | 0.757606 | 3 | 0 | 3 |
| RAB7A | BAZ1B | 0.75604 | 3 | 0 | 3 |
| RAB7A | KPNA6 | 0.746363 | 4 | 0 | 4 |
| RAB7A | PIP5K1C | 0.74137 | 3 | 0 | 3 |
| RAB7A | DUSP18 | 0.73944 | 3 | 0 | 3 |
| RAB7A | ZFYVE27 | 0.739075 | 3 | 0 | 3 |
| RAB7A | IFT80 | 0.738149 | 3 | 0 | 3 |
| RAB7A | PTPN23 | 0.736815 | 3 | 0 | 3 |
| RAB7A | TMEM41A | 0.736331 | 5 | 0 | 5 |
| RAB7A | AGPAT3 | 0.733382 | 3 | 0 | 3 |
| RAB7A | ZNF787 | 0.727618 | 4 | 0 | 3 |
| RAB7A | TRIAP1 | 0.723704 | 3 | 0 | 3 |
| RAB7A | THADA | 0.721797 | 3 | 0 | 3 |
For details and further investigation, click here
