| Full name: branched chain keto acid dehydrogenase kinase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 10295 | HGNC ID: HGNC:16902 | Ensembl Gene: ENSG00000103507 | OMIM ID: 614901 |
| Drug and gene relationship at DGIdb | |||
Expression of BCKDK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BCKDK | 10295 | 202030_at | 0.0829 | 0.8735 | |
| GSE20347 | BCKDK | 10295 | 202030_at | -0.0517 | 0.7474 | |
| GSE23400 | BCKDK | 10295 | 202030_at | 0.1131 | 0.0880 | |
| GSE26886 | BCKDK | 10295 | 202030_at | 0.1056 | 0.6023 | |
| GSE29001 | BCKDK | 10295 | 202030_at | -0.0929 | 0.6416 | |
| GSE38129 | BCKDK | 10295 | 202030_at | -0.0281 | 0.8236 | |
| GSE45670 | BCKDK | 10295 | 202030_at | 0.3046 | 0.0409 | |
| GSE53622 | BCKDK | 10295 | 132848 | 0.2658 | 0.0000 | |
| GSE53624 | BCKDK | 10295 | 69184 | 0.0317 | 0.5872 | |
| GSE63941 | BCKDK | 10295 | 202030_at | 0.1772 | 0.6977 | |
| GSE77861 | BCKDK | 10295 | 202030_at | -0.1379 | 0.5237 | |
| GSE97050 | BCKDK | 10295 | A_23_P365149 | 0.3275 | 0.1965 | |
| SRP007169 | BCKDK | 10295 | RNAseq | -0.7217 | 0.0430 | |
| SRP008496 | BCKDK | 10295 | RNAseq | -0.6770 | 0.0016 | |
| SRP064894 | BCKDK | 10295 | RNAseq | 0.4083 | 0.0605 | |
| SRP133303 | BCKDK | 10295 | RNAseq | 0.2311 | 0.1592 | |
| SRP159526 | BCKDK | 10295 | RNAseq | -0.1250 | 0.4548 | |
| SRP193095 | BCKDK | 10295 | RNAseq | 0.1349 | 0.2635 | |
| SRP219564 | BCKDK | 10295 | RNAseq | -0.0213 | 0.9446 | |
| TCGA | BCKDK | 10295 | RNAseq | -0.0964 | 0.0550 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BCKDK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BCKDK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BCKDK | 10295 | 4 | 5 | 21 | |
| GSE20123 | BCKDK | 10295 | 4 | 4 | 22 | |
| GSE43470 | BCKDK | 10295 | 3 | 3 | 37 | |
| GSE46452 | BCKDK | 10295 | 38 | 1 | 20 | |
| GSE47630 | BCKDK | 10295 | 11 | 7 | 22 | |
| GSE54993 | BCKDK | 10295 | 2 | 5 | 63 | |
| GSE54994 | BCKDK | 10295 | 5 | 9 | 39 | |
| GSE60625 | BCKDK | 10295 | 4 | 0 | 7 | |
| GSE74703 | BCKDK | 10295 | 3 | 2 | 31 | |
| GSE74704 | BCKDK | 10295 | 3 | 2 | 15 | |
| TCGA | BCKDK | 10295 | 20 | 10 | 66 |
Total number of gains: 97; Total number of losses: 48; Total Number of normals: 343.
Somatic mutations of BCKDK:
Generating mutation plots.
Highly correlated genes for BCKDK:
Showing top 20/240 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BCKDK | USP3 | 0.755009 | 3 | 0 | 3 |
| BCKDK | PCDH12 | 0.742501 | 3 | 0 | 3 |
| BCKDK | SUPT4H1 | 0.732839 | 4 | 0 | 4 |
| BCKDK | NDUFV1 | 0.730865 | 3 | 0 | 3 |
| BCKDK | AMPD3 | 0.72166 | 3 | 0 | 3 |
| BCKDK | FBRS | 0.719511 | 3 | 0 | 3 |
| BCKDK | ELFN1 | 0.711327 | 3 | 0 | 3 |
| BCKDK | SLC24A1 | 0.71112 | 3 | 0 | 3 |
| BCKDK | ZNF213 | 0.699213 | 3 | 0 | 3 |
| BCKDK | MRPS11 | 0.698394 | 3 | 0 | 3 |
| BCKDK | ROBO4 | 0.69217 | 3 | 0 | 3 |
| BCKDK | COPZ1 | 0.691575 | 4 | 0 | 4 |
| BCKDK | ALDOA | 0.687519 | 8 | 0 | 8 |
| BCKDK | UCKL1 | 0.686532 | 3 | 0 | 3 |
| BCKDK | PCCB | 0.683219 | 3 | 0 | 3 |
| BCKDK | TCEANC2 | 0.681798 | 4 | 0 | 3 |
| BCKDK | HERPUD1 | 0.680675 | 3 | 0 | 3 |
| BCKDK | AKT1S1 | 0.678925 | 3 | 0 | 3 |
| BCKDK | HIRA | 0.677443 | 3 | 0 | 3 |
| BCKDK | FAM171B | 0.67739 | 3 | 0 | 3 |
For details and further investigation, click here
