| Full name: twinfilin actin binding protein 2 | Alias Symbol: A6RP|A6r | ||
| Type: protein-coding gene | Cytoband: 3p21.2 | ||
| Entrez ID: 11344 | HGNC ID: HGNC:9621 | Ensembl Gene: ENSG00000247596 | OMIM ID: 607433 |
| Drug and gene relationship at DGIdb | |||
Expression of TWF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TWF2 | 11344 | 202009_at | -0.0083 | 0.9826 | |
| GSE20347 | TWF2 | 11344 | 202009_at | -0.4178 | 0.0000 | |
| GSE23400 | TWF2 | 11344 | 202009_at | -0.0562 | 0.1455 | |
| GSE26886 | TWF2 | 11344 | 202009_at | -0.2873 | 0.0323 | |
| GSE29001 | TWF2 | 11344 | 202009_at | -0.4854 | 0.0037 | |
| GSE38129 | TWF2 | 11344 | 202009_at | -0.2134 | 0.0012 | |
| GSE45670 | TWF2 | 11344 | 202009_at | -0.1001 | 0.2578 | |
| GSE63941 | TWF2 | 11344 | 202009_at | -0.5553 | 0.1032 | |
| GSE77861 | TWF2 | 11344 | 202009_at | -0.1849 | 0.2798 | |
| GSE97050 | TWF2 | 11344 | A_23_P121265 | 0.1967 | 0.4147 | |
| SRP007169 | TWF2 | 11344 | RNAseq | -0.7512 | 0.0939 | |
| SRP008496 | TWF2 | 11344 | RNAseq | -0.7964 | 0.0055 | |
| SRP064894 | TWF2 | 11344 | RNAseq | 0.5001 | 0.0761 | |
| SRP133303 | TWF2 | 11344 | RNAseq | -0.2428 | 0.0919 | |
| SRP159526 | TWF2 | 11344 | RNAseq | -0.8212 | 0.0008 | |
| SRP193095 | TWF2 | 11344 | RNAseq | -0.4077 | 0.0004 | |
| SRP219564 | TWF2 | 11344 | RNAseq | -0.2980 | 0.3001 | |
| TCGA | TWF2 | 11344 | RNAseq | 0.0870 | 0.1270 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TWF2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TWF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TWF2 | 11344 | 0 | 18 | 12 | |
| GSE20123 | TWF2 | 11344 | 0 | 19 | 11 | |
| GSE43470 | TWF2 | 11344 | 0 | 18 | 25 | |
| GSE46452 | TWF2 | 11344 | 2 | 17 | 40 | |
| GSE47630 | TWF2 | 11344 | 1 | 24 | 15 | |
| GSE54993 | TWF2 | 11344 | 6 | 2 | 62 | |
| GSE54994 | TWF2 | 11344 | 0 | 34 | 19 | |
| GSE60625 | TWF2 | 11344 | 5 | 0 | 6 | |
| GSE74703 | TWF2 | 11344 | 0 | 14 | 22 | |
| GSE74704 | TWF2 | 11344 | 0 | 12 | 8 | |
| TCGA | TWF2 | 11344 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 236; Total Number of normals: 238.
Somatic mutations of TWF2:
Generating mutation plots.
Highly correlated genes for TWF2:
Showing top 20/577 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TWF2 | RBPJL | 0.728815 | 3 | 0 | 3 |
| TWF2 | ALDOA | 0.706855 | 5 | 0 | 5 |
| TWF2 | HSBP1 | 0.706828 | 3 | 0 | 3 |
| TWF2 | HK1 | 0.701764 | 4 | 0 | 4 |
| TWF2 | AP1B1 | 0.695645 | 7 | 0 | 7 |
| TWF2 | FHL3 | 0.695253 | 3 | 0 | 3 |
| TWF2 | GIPC1 | 0.691664 | 5 | 0 | 4 |
| TWF2 | PHKB | 0.685644 | 4 | 0 | 4 |
| TWF2 | WNT5A | 0.684345 | 3 | 0 | 3 |
| TWF2 | GPSM2 | 0.684256 | 3 | 0 | 3 |
| TWF2 | LDHD | 0.681983 | 4 | 0 | 4 |
| TWF2 | WDR41 | 0.680754 | 4 | 0 | 3 |
| TWF2 | MAP3K1 | 0.677375 | 4 | 0 | 4 |
| TWF2 | MVP | 0.675385 | 5 | 0 | 4 |
| TWF2 | PRDX2 | 0.674981 | 3 | 0 | 3 |
| TWF2 | ITPRIP | 0.674488 | 3 | 0 | 3 |
| TWF2 | SNX33 | 0.672675 | 4 | 0 | 3 |
| TWF2 | TMEM141 | 0.671255 | 3 | 0 | 3 |
| TWF2 | PFKL | 0.67112 | 7 | 0 | 5 |
| TWF2 | PRRC1 | 0.670435 | 4 | 0 | 3 |
For details and further investigation, click here
