| Full name: sodium voltage-gated channel beta subunit 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.11 | ||
| Entrez ID: 6324 | HGNC ID: HGNC:10586 | Ensembl Gene: ENSG00000105711 | OMIM ID: 600235 |
| Drug and gene relationship at DGIdb | |||
SCN1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04261 | Adrenergic signaling in cardiomyocytes |
Expression of SCN1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCN1B | 6324 | 205508_at | -0.1442 | 0.7026 | |
| GSE20347 | SCN1B | 6324 | 205508_at | 0.2489 | 0.0073 | |
| GSE23400 | SCN1B | 6324 | 205508_at | 0.0535 | 0.2958 | |
| GSE26886 | SCN1B | 6324 | 205508_at | 0.5972 | 0.0167 | |
| GSE29001 | SCN1B | 6324 | 205508_at | 0.2184 | 0.4409 | |
| GSE38129 | SCN1B | 6324 | 205508_at | -0.0272 | 0.8575 | |
| GSE45670 | SCN1B | 6324 | 205508_at | -0.2911 | 0.1040 | |
| GSE53622 | SCN1B | 6324 | 110801 | -0.3537 | 0.0001 | |
| GSE53624 | SCN1B | 6324 | 110801 | -0.1970 | 0.0044 | |
| GSE63941 | SCN1B | 6324 | 205508_at | -0.2710 | 0.5159 | |
| GSE77861 | SCN1B | 6324 | 205508_at | 0.2381 | 0.2241 | |
| GSE97050 | SCN1B | 6324 | A_23_P79015 | -0.1221 | 0.5704 | |
| SRP007169 | SCN1B | 6324 | RNAseq | 3.7060 | 0.0000 | |
| SRP064894 | SCN1B | 6324 | RNAseq | 1.0867 | 0.0043 | |
| SRP133303 | SCN1B | 6324 | RNAseq | -0.0026 | 0.9920 | |
| SRP159526 | SCN1B | 6324 | RNAseq | 0.4695 | 0.2277 | |
| SRP193095 | SCN1B | 6324 | RNAseq | 1.0961 | 0.0000 | |
| SRP219564 | SCN1B | 6324 | RNAseq | 0.5565 | 0.4783 | |
| TCGA | SCN1B | 6324 | RNAseq | -0.4033 | 0.0283 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SCN1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCN1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCN1B | 6324 | 6 | 5 | 19 | |
| GSE20123 | SCN1B | 6324 | 6 | 4 | 20 | |
| GSE43470 | SCN1B | 6324 | 4 | 7 | 32 | |
| GSE46452 | SCN1B | 6324 | 48 | 1 | 10 | |
| GSE47630 | SCN1B | 6324 | 8 | 6 | 26 | |
| GSE54993 | SCN1B | 6324 | 17 | 3 | 50 | |
| GSE54994 | SCN1B | 6324 | 9 | 9 | 35 | |
| GSE60625 | SCN1B | 6324 | 9 | 0 | 2 | |
| GSE74703 | SCN1B | 6324 | 4 | 4 | 28 | |
| GSE74704 | SCN1B | 6324 | 6 | 2 | 12 | |
| TCGA | SCN1B | 6324 | 21 | 11 | 64 |
Total number of gains: 138; Total number of losses: 52; Total Number of normals: 298.
Somatic mutations of SCN1B:
Generating mutation plots.
Highly correlated genes for SCN1B:
Showing top 20/482 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCN1B | PGLYRP1 | 0.787831 | 3 | 0 | 3 |
| SCN1B | TREM1 | 0.783822 | 3 | 0 | 3 |
| SCN1B | SCARA5 | 0.765596 | 3 | 0 | 3 |
| SCN1B | DOK7 | 0.763279 | 3 | 0 | 3 |
| SCN1B | ALKBH5 | 0.754754 | 3 | 0 | 3 |
| SCN1B | AGAP2 | 0.729739 | 4 | 0 | 3 |
| SCN1B | LRRN4 | 0.720808 | 3 | 0 | 3 |
| SCN1B | DPYSL4 | 0.713319 | 4 | 0 | 4 |
| SCN1B | ANKDD1A | 0.701752 | 4 | 0 | 4 |
| SCN1B | LIM2 | 0.700832 | 3 | 0 | 3 |
| SCN1B | KCNK9 | 0.699273 | 3 | 0 | 3 |
| SCN1B | CTRL | 0.691869 | 3 | 0 | 3 |
| SCN1B | TXNDC2 | 0.689053 | 3 | 0 | 3 |
| SCN1B | TOX2 | 0.686809 | 4 | 0 | 4 |
| SCN1B | CHSY3 | 0.686746 | 3 | 0 | 3 |
| SCN1B | FSCN2 | 0.684432 | 3 | 0 | 3 |
| SCN1B | GLI1 | 0.678972 | 3 | 0 | 3 |
| SCN1B | HSF4 | 0.67827 | 5 | 0 | 4 |
| SCN1B | TEKT2 | 0.677237 | 3 | 0 | 3 |
| SCN1B | IL20 | 0.666247 | 3 | 0 | 3 |
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