DRG2

 

Full name: developmentally regulated GTP binding protein 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 17p11.2
Entrez ID: 1819 HGNC ID: HGNC:3030 Ensembl Gene: ENSG00000108591 OMIM ID: 602986
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of DRG2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DRG2 1819 203267_s_at 0.1634 0.5325
GSE20347 DRG2 1819 203267_s_at 0.0832 0.5971
GSE23400 DRG2 1819 203268_s_at 0.0051 0.8986
GSE26886 DRG2 1819 203268_s_at 0.2514 0.1530
GSE29001 DRG2 1819 203268_s_at 0.0286 0.8942
GSE38129 DRG2 1819 203267_s_at 0.0776 0.5195
GSE45670 DRG2 1819 203267_s_at 0.2285 0.0684
GSE63941 DRG2 1819 203267_s_at 1.5045 0.0163
GSE77861 DRG2 1819 203267_s_at 0.1083 0.5253
GSE97050 DRG2 1819 A_23_P141656 0.1612 0.5302
SRP007169 DRG2 1819 RNAseq -0.3057 0.3452
SRP008496 DRG2 1819 RNAseq -0.4893 0.0375
SRP064894 DRG2 1819 RNAseq 0.8041 0.0005
SRP133303 DRG2 1819 RNAseq 0.3031 0.0334
SRP159526 DRG2 1819 RNAseq 0.3071 0.1245
SRP193095 DRG2 1819 RNAseq 0.2016 0.0374
SRP219564 DRG2 1819 RNAseq 0.2461 0.3518
TCGA DRG2 1819 RNAseq 0.0908 0.0934

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by DRG2 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of DRG2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DRG2 1819 3 3 24
GSE20123 DRG2 1819 3 4 23
GSE43470 DRG2 1819 1 5 37
GSE46452 DRG2 1819 34 1 24
GSE47630 DRG2 1819 7 1 32
GSE54993 DRG2 1819 3 3 64
GSE54994 DRG2 1819 6 6 41
GSE60625 DRG2 1819 4 0 7
GSE74703 DRG2 1819 1 2 33
GSE74704 DRG2 1819 2 1 17
TCGA DRG2 1819 18 23 55

Total number of gains: 82; Total number of losses: 49; Total Number of normals: 357.  

 

Somatic mutations of DRG2:

 

Generating mutation plots.

 

Highly correlated genes for DRG2:

 

Showing top 20/181 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DRG2PSPN0.768896303
DRG2ADAMTS130.760636303
DRG2ABCC60.752025303
DRG2ZFAT0.750293303
DRG2ALKBH50.727377404
DRG2LILRA10.71206303
DRG2JAKMIP30.709449303
DRG2RNF1230.706585303
DRG2CEMP10.699464303
DRG2CNOT30.687863303
DRG2KCNC30.686389303
DRG2LIM20.677894403
DRG2ADRA2C0.673044303
DRG2NUBP20.671069303
DRG2ABCC20.668144303
DRG2SLC22A110.667705403
DRG2TEX13B0.663547403
DRG2EFNB10.663472504
DRG2VAV20.661379403
DRG2MTFP10.660464403

For details and further investigation, click here