| Full name: 1-acylglycerol-3-phosphate O-acyltransferase 1 | Alias Symbol: LPAAT-alpha | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 10554 | HGNC ID: HGNC:324 | Ensembl Gene: ENSG00000204310 | OMIM ID: 603099 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of AGPAT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AGPAT1 | 10554 | 32836_at | 0.2387 | 0.6388 | |
| GSE20347 | AGPAT1 | 10554 | 32836_at | 0.2271 | 0.0281 | |
| GSE23400 | AGPAT1 | 10554 | 32836_at | 0.1673 | 0.0005 | |
| GSE26886 | AGPAT1 | 10554 | 32836_at | -0.1746 | 0.2457 | |
| GSE29001 | AGPAT1 | 10554 | 32836_at | -0.0493 | 0.8045 | |
| GSE38129 | AGPAT1 | 10554 | 32836_at | 0.0461 | 0.7814 | |
| GSE45670 | AGPAT1 | 10554 | 32836_at | 0.0943 | 0.3465 | |
| GSE63941 | AGPAT1 | 10554 | 32836_at | -0.4646 | 0.2770 | |
| GSE77861 | AGPAT1 | 10554 | 32836_at | 0.1139 | 0.6002 | |
| GSE97050 | AGPAT1 | 10554 | A_23_P258093 | 0.0135 | 0.9534 | |
| SRP007169 | AGPAT1 | 10554 | RNAseq | 0.3695 | 0.2759 | |
| SRP008496 | AGPAT1 | 10554 | RNAseq | 0.4466 | 0.0290 | |
| SRP064894 | AGPAT1 | 10554 | RNAseq | 0.7671 | 0.0030 | |
| SRP133303 | AGPAT1 | 10554 | RNAseq | 0.2012 | 0.1525 | |
| SRP159526 | AGPAT1 | 10554 | RNAseq | 0.3933 | 0.0692 | |
| SRP193095 | AGPAT1 | 10554 | RNAseq | 0.3162 | 0.0628 | |
| SRP219564 | AGPAT1 | 10554 | RNAseq | -0.0287 | 0.9511 | |
| TCGA | AGPAT1 | 10554 | RNAseq | -0.1988 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AGPAT1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of AGPAT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AGPAT1 | 10554 | 5 | 1 | 24 | |
| GSE20123 | AGPAT1 | 10554 | 5 | 1 | 24 | |
| GSE43470 | AGPAT1 | 10554 | 5 | 1 | 37 | |
| GSE46452 | AGPAT1 | 10554 | 1 | 10 | 48 | |
| GSE47630 | AGPAT1 | 10554 | 7 | 4 | 29 | |
| GSE54993 | AGPAT1 | 10554 | 2 | 1 | 67 | |
| GSE54994 | AGPAT1 | 10554 | 11 | 4 | 38 | |
| GSE60625 | AGPAT1 | 10554 | 0 | 1 | 10 | |
| GSE74703 | AGPAT1 | 10554 | 5 | 0 | 31 | |
| GSE74704 | AGPAT1 | 10554 | 2 | 0 | 18 | |
| TCGA | AGPAT1 | 10554 | 16 | 16 | 64 |
Total number of gains: 59; Total number of losses: 39; Total Number of normals: 390.
Somatic mutations of AGPAT1:
Generating mutation plots.
Highly correlated genes for AGPAT1:
Showing top 20/128 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AGPAT1 | SLC35G1 | 0.760814 | 3 | 0 | 3 |
| AGPAT1 | ZNF526 | 0.722215 | 3 | 0 | 3 |
| AGPAT1 | ALKBH5 | 0.716773 | 3 | 0 | 3 |
| AGPAT1 | PTPN18 | 0.710326 | 3 | 0 | 3 |
| AGPAT1 | ADCY1 | 0.708429 | 3 | 0 | 3 |
| AGPAT1 | SV2B | 0.705884 | 4 | 0 | 4 |
| AGPAT1 | IFT27 | 0.691616 | 4 | 0 | 3 |
| AGPAT1 | FBXL15 | 0.686033 | 4 | 0 | 3 |
| AGPAT1 | SLC22A16 | 0.677514 | 3 | 0 | 3 |
| AGPAT1 | POLD1 | 0.675221 | 3 | 0 | 3 |
| AGPAT1 | LMAN1L | 0.672529 | 3 | 0 | 3 |
| AGPAT1 | ASTN2 | 0.671974 | 4 | 0 | 3 |
| AGPAT1 | MIIP | 0.668154 | 3 | 0 | 3 |
| AGPAT1 | CHTF8 | 0.667413 | 3 | 0 | 3 |
| AGPAT1 | SYPL2 | 0.664058 | 4 | 0 | 3 |
| AGPAT1 | RANBP3 | 0.662677 | 5 | 0 | 3 |
| AGPAT1 | SAMD4A | 0.661545 | 4 | 0 | 3 |
| AGPAT1 | TESC | 0.660237 | 3 | 0 | 3 |
| AGPAT1 | CHST10 | 0.659849 | 4 | 0 | 3 |
| AGPAT1 | LY6G5C | 0.659549 | 4 | 0 | 3 |
For details and further investigation, click here
