| Full name: alkB homolog 8, tRNA methyltransferase | Alias Symbol: MGC10235|TRM9|TRMT9A | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 91801 | HGNC ID: HGNC:25189 | Ensembl Gene: ENSG00000137760 | OMIM ID: 613306 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ALKBH8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALKBH8 | 91801 | 235713_at | -0.0973 | 0.7870 | |
| GSE26886 | ALKBH8 | 91801 | 235713_at | -0.8461 | 0.0000 | |
| GSE45670 | ALKBH8 | 91801 | 235713_at | -0.2362 | 0.1367 | |
| GSE53622 | ALKBH8 | 91801 | 158710 | -0.2264 | 0.0121 | |
| GSE53624 | ALKBH8 | 91801 | 160939 | 0.0024 | 0.9787 | |
| GSE63941 | ALKBH8 | 91801 | 235713_at | 0.1475 | 0.7461 | |
| GSE77861 | ALKBH8 | 91801 | 235713_at | -0.0566 | 0.6815 | |
| GSE97050 | ALKBH8 | 91801 | A_33_P3318357 | 0.1918 | 0.6083 | |
| SRP007169 | ALKBH8 | 91801 | RNAseq | 0.5609 | 0.3069 | |
| SRP008496 | ALKBH8 | 91801 | RNAseq | 0.4025 | 0.2876 | |
| SRP064894 | ALKBH8 | 91801 | RNAseq | -0.1535 | 0.4732 | |
| SRP133303 | ALKBH8 | 91801 | RNAseq | -0.1821 | 0.1968 | |
| SRP159526 | ALKBH8 | 91801 | RNAseq | -0.7231 | 0.0015 | |
| SRP193095 | ALKBH8 | 91801 | RNAseq | -0.5193 | 0.0000 | |
| SRP219564 | ALKBH8 | 91801 | RNAseq | -0.2973 | 0.1816 | |
| TCGA | ALKBH8 | 91801 | RNAseq | -0.0568 | 0.4215 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALKBH8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALKBH8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALKBH8 | 91801 | 0 | 13 | 17 | |
| GSE20123 | ALKBH8 | 91801 | 0 | 13 | 17 | |
| GSE43470 | ALKBH8 | 91801 | 2 | 6 | 35 | |
| GSE46452 | ALKBH8 | 91801 | 3 | 26 | 30 | |
| GSE47630 | ALKBH8 | 91801 | 2 | 19 | 19 | |
| GSE54993 | ALKBH8 | 91801 | 9 | 1 | 60 | |
| GSE54994 | ALKBH8 | 91801 | 5 | 19 | 29 | |
| GSE60625 | ALKBH8 | 91801 | 0 | 3 | 8 | |
| GSE74703 | ALKBH8 | 91801 | 1 | 4 | 31 | |
| GSE74704 | ALKBH8 | 91801 | 0 | 9 | 11 | |
| TCGA | ALKBH8 | 91801 | 6 | 48 | 42 |
Total number of gains: 28; Total number of losses: 161; Total Number of normals: 299.
Somatic mutations of ALKBH8:
Generating mutation plots.
Highly correlated genes for ALKBH8:
Showing top 20/86 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALKBH8 | RBM5 | 0.784184 | 3 | 0 | 3 |
| ALKBH8 | PLXNA2 | 0.767044 | 3 | 0 | 3 |
| ALKBH8 | C1orf21 | 0.751562 | 3 | 0 | 3 |
| ALKBH8 | STX17 | 0.748372 | 3 | 0 | 3 |
| ALKBH8 | FBXW7 | 0.729542 | 3 | 0 | 3 |
| ALKBH8 | PRKAG1 | 0.724113 | 3 | 0 | 3 |
| ALKBH8 | ZBED6 | 0.722514 | 3 | 0 | 3 |
| ALKBH8 | PRADC1 | 0.722265 | 3 | 0 | 3 |
| ALKBH8 | GLUD2 | 0.719588 | 3 | 0 | 3 |
| ALKBH8 | RUFY3 | 0.716474 | 3 | 0 | 3 |
| ALKBH8 | HIBCH | 0.715277 | 3 | 0 | 3 |
| ALKBH8 | DALRD3 | 0.713344 | 3 | 0 | 3 |
| ALKBH8 | RBM7 | 0.711077 | 3 | 0 | 3 |
| ALKBH8 | RABGAP1 | 0.708493 | 3 | 0 | 3 |
| ALKBH8 | PLXNB1 | 0.707538 | 3 | 0 | 3 |
| ALKBH8 | NDUFA10 | 0.70577 | 3 | 0 | 3 |
| ALKBH8 | ENSA | 0.696333 | 3 | 0 | 3 |
| ALKBH8 | SLC16A14 | 0.695938 | 3 | 0 | 3 |
| ALKBH8 | CNST | 0.691372 | 3 | 0 | 3 |
| ALKBH8 | ZFP3 | 0.685071 | 3 | 0 | 3 |
For details and further investigation, click here
