| Full name: F-box and WD repeat domain containing 7 | Alias Symbol: AGO|FLJ11071|SEL-10|SEL10|FBW7|FBX30|CDC4|FBXW6 | ||
| Type: protein-coding gene | Cytoband: 4q31.3 | ||
| Entrez ID: 55294 | HGNC ID: HGNC:16712 | Ensembl Gene: ENSG00000109670 | OMIM ID: 606278 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of FBXW7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXW7 | 55294 | 218751_s_at | -0.2803 | 0.5495 | |
| GSE20347 | FBXW7 | 55294 | 218751_s_at | -0.7348 | 0.0001 | |
| GSE23400 | FBXW7 | 55294 | 218751_s_at | -0.5280 | 0.0000 | |
| GSE26886 | FBXW7 | 55294 | 229419_at | -1.5643 | 0.0000 | |
| GSE29001 | FBXW7 | 55294 | 218751_s_at | -1.0414 | 0.0004 | |
| GSE38129 | FBXW7 | 55294 | 218751_s_at | -0.6412 | 0.0000 | |
| GSE45670 | FBXW7 | 55294 | 229419_at | -0.3818 | 0.0969 | |
| GSE53622 | FBXW7 | 55294 | 61066 | -0.8445 | 0.0000 | |
| GSE53624 | FBXW7 | 55294 | 61066 | -1.0097 | 0.0000 | |
| GSE63941 | FBXW7 | 55294 | 229419_at | -1.5561 | 0.0007 | |
| GSE77861 | FBXW7 | 55294 | 218751_s_at | -0.4811 | 0.0213 | |
| GSE97050 | FBXW7 | 55294 | A_24_P174613 | -0.4063 | 0.1931 | |
| SRP007169 | FBXW7 | 55294 | RNAseq | -1.1520 | 0.0005 | |
| SRP008496 | FBXW7 | 55294 | RNAseq | -0.5825 | 0.0126 | |
| SRP064894 | FBXW7 | 55294 | RNAseq | -0.7177 | 0.0000 | |
| SRP133303 | FBXW7 | 55294 | RNAseq | -0.0219 | 0.8996 | |
| SRP159526 | FBXW7 | 55294 | RNAseq | -0.7412 | 0.0000 | |
| SRP193095 | FBXW7 | 55294 | RNAseq | -0.5277 | 0.0013 | |
| SRP219564 | FBXW7 | 55294 | RNAseq | -1.0050 | 0.0027 | |
| TCGA | FBXW7 | 55294 | RNAseq | -0.1667 | 0.0122 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by FBXW7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXW7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXW7 | 55294 | 0 | 14 | 16 | |
| GSE20123 | FBXW7 | 55294 | 0 | 14 | 16 | |
| GSE43470 | FBXW7 | 55294 | 0 | 14 | 29 | |
| GSE46452 | FBXW7 | 55294 | 1 | 36 | 22 | |
| GSE47630 | FBXW7 | 55294 | 0 | 23 | 17 | |
| GSE54993 | FBXW7 | 55294 | 10 | 0 | 60 | |
| GSE54994 | FBXW7 | 55294 | 1 | 13 | 39 | |
| GSE60625 | FBXW7 | 55294 | 0 | 1 | 10 | |
| GSE74703 | FBXW7 | 55294 | 0 | 12 | 24 | |
| GSE74704 | FBXW7 | 55294 | 0 | 7 | 13 | |
| TCGA | FBXW7 | 55294 | 11 | 36 | 49 |
Total number of gains: 23; Total number of losses: 170; Total Number of normals: 295.
Somatic mutations of FBXW7:
Generating mutation plots.
Highly correlated genes for FBXW7:
Showing top 20/1309 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXW7 | WDR27 | 0.804749 | 3 | 0 | 3 |
| FBXW7 | SLC25A27 | 0.802976 | 3 | 0 | 3 |
| FBXW7 | CHCHD1 | 0.756017 | 3 | 0 | 3 |
| FBXW7 | TMEM38A | 0.753483 | 3 | 0 | 3 |
| FBXW7 | IPMK | 0.752414 | 3 | 0 | 3 |
| FBXW7 | EEPD1 | 0.751535 | 3 | 0 | 3 |
| FBXW7 | TAB3 | 0.741791 | 6 | 0 | 6 |
| FBXW7 | ZBED6 | 0.737712 | 3 | 0 | 3 |
| FBXW7 | GPCPD1 | 0.737504 | 4 | 0 | 4 |
| FBXW7 | ESYT2 | 0.736496 | 4 | 0 | 4 |
| FBXW7 | CA13 | 0.733094 | 3 | 0 | 3 |
| FBXW7 | ALKBH8 | 0.729542 | 3 | 0 | 3 |
| FBXW7 | GTPBP1 | 0.727745 | 3 | 0 | 3 |
| FBXW7 | ICA1L | 0.721819 | 3 | 0 | 3 |
| FBXW7 | EIF4E3 | 0.720199 | 6 | 0 | 6 |
| FBXW7 | RAB10 | 0.720083 | 4 | 0 | 4 |
| FBXW7 | ZNF416 | 0.718222 | 4 | 0 | 3 |
| FBXW7 | NAA35 | 0.717862 | 3 | 0 | 3 |
| FBXW7 | PDLIM2 | 0.715465 | 8 | 0 | 7 |
| FBXW7 | PITHD1 | 0.714957 | 6 | 0 | 5 |
For details and further investigation, click here
