| Full name: sonic hedgehog signaling molecule | Alias Symbol: HHG1|SMMCI|TPT|TPTPS|MCOPCB5 | ||
| Type: protein-coding gene | Cytoband: 7q36.3 | ||
| Entrez ID: 6469 | HGNC ID: HGNC:10848 | Ensembl Gene: ENSG00000164690 | OMIM ID: 600725 |
| Drug and gene relationship at DGIdb | |||
SHH involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04340 | Hedgehog signaling pathway | |
| hsa04360 | Axon guidance | |
| hsa05200 | Pathways in cancer | |
| hsa05217 | Basal cell carcinoma |
Expression of SHH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHH | 6469 | 236263_at | -0.0772 | 0.7012 | |
| GSE20347 | SHH | 6469 | 207586_at | 0.0679 | 0.3374 | |
| GSE23400 | SHH | 6469 | 207586_at | -0.1430 | 0.0001 | |
| GSE26886 | SHH | 6469 | 236263_at | 0.2852 | 0.2110 | |
| GSE29001 | SHH | 6469 | 207586_at | 0.0675 | 0.6661 | |
| GSE38129 | SHH | 6469 | 207586_at | -0.0066 | 0.9309 | |
| GSE45670 | SHH | 6469 | 236263_at | 0.1818 | 0.1452 | |
| GSE53622 | SHH | 6469 | 35009 | 0.4841 | 0.0000 | |
| GSE53624 | SHH | 6469 | 91509 | -0.0641 | 0.7516 | |
| GSE63941 | SHH | 6469 | 236263_at | 0.2920 | 0.5887 | |
| GSE77861 | SHH | 6469 | 236263_at | 0.3870 | 0.4807 | |
| GSE97050 | SHH | 6469 | A_23_P111657 | -0.1296 | 0.6499 | |
| SRP133303 | SHH | 6469 | RNAseq | 1.6115 | 0.0013 | |
| SRP159526 | SHH | 6469 | RNAseq | 7.2050 | 0.0000 | |
| TCGA | SHH | 6469 | RNAseq | -1.8809 | 0.0417 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by SHH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHH | 6469 | 3 | 3 | 24 | |
| GSE20123 | SHH | 6469 | 2 | 3 | 25 | |
| GSE43470 | SHH | 6469 | 2 | 5 | 36 | |
| GSE46452 | SHH | 6469 | 7 | 2 | 50 | |
| GSE47630 | SHH | 6469 | 6 | 9 | 25 | |
| GSE54993 | SHH | 6469 | 3 | 3 | 64 | |
| GSE54994 | SHH | 6469 | 6 | 8 | 39 | |
| GSE60625 | SHH | 6469 | 0 | 0 | 11 | |
| GSE74703 | SHH | 6469 | 2 | 4 | 30 | |
| GSE74704 | SHH | 6469 | 0 | 3 | 17 | |
| TCGA | SHH | 6469 | 27 | 26 | 43 |
Total number of gains: 58; Total number of losses: 66; Total Number of normals: 364.
Somatic mutations of SHH:
Generating mutation plots.
Highly correlated genes for SHH:
Showing top 20/182 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHH | CDH2 | 0.725332 | 3 | 0 | 3 |
| SHH | ALPL | 0.712375 | 3 | 0 | 3 |
| SHH | PRODH2 | 0.707926 | 4 | 0 | 4 |
| SHH | CELF5 | 0.706975 | 3 | 0 | 3 |
| SHH | KATNAL2 | 0.704086 | 3 | 0 | 3 |
| SHH | FOXA2 | 0.693918 | 5 | 0 | 5 |
| SHH | LACRT | 0.693359 | 3 | 0 | 3 |
| SHH | KCTD19 | 0.685133 | 3 | 0 | 3 |
| SHH | GPR146 | 0.673652 | 3 | 0 | 3 |
| SHH | RAD52 | 0.662145 | 3 | 0 | 3 |
| SHH | PKDCC | 0.662078 | 3 | 0 | 3 |
| SHH | SCTR | 0.654275 | 3 | 0 | 3 |
| SHH | CLDN19 | 0.652906 | 3 | 0 | 3 |
| SHH | CPN1 | 0.648227 | 3 | 0 | 3 |
| SHH | CEND1 | 0.64391 | 4 | 0 | 3 |
| SHH | KCNMB2 | 0.643642 | 4 | 0 | 3 |
| SHH | TESC | 0.642462 | 5 | 0 | 4 |
| SHH | MROH7 | 0.637085 | 4 | 0 | 3 |
| SHH | SHC2 | 0.635922 | 4 | 0 | 3 |
| SHH | VWA2 | 0.634727 | 3 | 0 | 3 |
For details and further investigation, click here
