| Full name: CD274 molecule | Alias Symbol: B7-H|B7H1|PD-L1|PDL1|B7-H1 | ||
| Type: protein-coding gene | Cytoband: 9p24.1 | ||
| Entrez ID: 29126 | HGNC ID: HGNC:17635 | Ensembl Gene: ENSG00000120217 | OMIM ID: 605402 |
| Drug and gene relationship at DGIdb | |||
Expression of CD274:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD274 | 29126 | 227458_at | 0.3010 | 0.7300 | |
| GSE26886 | CD274 | 29126 | 227458_at | -0.6533 | 0.2661 | |
| GSE45670 | CD274 | 29126 | 227458_at | 0.7579 | 0.0787 | |
| GSE53622 | CD274 | 29126 | 81434 | 0.5665 | 0.0001 | |
| GSE53624 | CD274 | 29126 | 81434 | 0.6228 | 0.0000 | |
| GSE63941 | CD274 | 29126 | 227458_at | -3.6332 | 0.0076 | |
| GSE77861 | CD274 | 29126 | 223834_at | -0.0651 | 0.6893 | |
| GSE97050 | CD274 | 29126 | A_23_P338479 | 0.5931 | 0.4887 | |
| SRP007169 | CD274 | 29126 | RNAseq | 2.4753 | 0.0005 | |
| SRP064894 | CD274 | 29126 | RNAseq | 0.4573 | 0.1916 | |
| SRP133303 | CD274 | 29126 | RNAseq | 0.5641 | 0.0059 | |
| SRP159526 | CD274 | 29126 | RNAseq | 0.4111 | 0.5144 | |
| SRP193095 | CD274 | 29126 | RNAseq | 0.8036 | 0.0007 | |
| SRP219564 | CD274 | 29126 | RNAseq | 0.6953 | 0.3862 | |
| TCGA | CD274 | 29126 | RNAseq | 0.7175 | 0.0029 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CD274 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD274:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD274 | 29126 | 1 | 17 | 12 | |
| GSE20123 | CD274 | 29126 | 1 | 17 | 12 | |
| GSE43470 | CD274 | 29126 | 5 | 11 | 27 | |
| GSE46452 | CD274 | 29126 | 2 | 23 | 34 | |
| GSE47630 | CD274 | 29126 | 5 | 26 | 9 | |
| GSE54993 | CD274 | 29126 | 6 | 3 | 61 | |
| GSE54994 | CD274 | 29126 | 9 | 17 | 27 | |
| GSE60625 | CD274 | 29126 | 0 | 2 | 9 | |
| GSE74703 | CD274 | 29126 | 5 | 8 | 23 | |
| GSE74704 | CD274 | 29126 | 0 | 13 | 7 | |
| TCGA | CD274 | 29126 | 14 | 50 | 32 |
Total number of gains: 48; Total number of losses: 187; Total Number of normals: 253.
Somatic mutations of CD274:
Generating mutation plots.
Highly correlated genes for CD274:
Showing top 20/28 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD274 | UBASH3B | 0.743526 | 3 | 0 | 3 |
| CD274 | ALPL | 0.739566 | 3 | 0 | 3 |
| CD274 | MMP19 | 0.652905 | 3 | 0 | 3 |
| CD274 | LST1 | 0.648717 | 3 | 0 | 3 |
| CD274 | ARSA | 0.640923 | 5 | 0 | 3 |
| CD274 | PTGER1 | 0.624311 | 3 | 0 | 3 |
| CD274 | GPR35 | 0.624059 | 3 | 0 | 3 |
| CD274 | DTNB | 0.620215 | 3 | 0 | 3 |
| CD274 | IL15RA | 0.617733 | 4 | 0 | 3 |
| CD274 | BCL6B | 0.601232 | 3 | 0 | 3 |
| CD274 | CC2D1B | 0.584059 | 4 | 0 | 3 |
| CD274 | HYAL2 | 0.583398 | 4 | 0 | 3 |
| CD274 | CD72 | 0.574618 | 4 | 0 | 3 |
| CD274 | SLC5A5 | 0.57126 | 3 | 0 | 3 |
| CD274 | CYB561D2 | 0.568918 | 5 | 0 | 3 |
| CD274 | BMP10 | 0.558429 | 4 | 0 | 3 |
| CD274 | TMEM105 | 0.555769 | 4 | 0 | 3 |
| CD274 | SIRPA | 0.546982 | 4 | 0 | 3 |
| CD274 | FFAR2 | 0.542248 | 4 | 0 | 3 |
| CD274 | IDO1 | 0.541638 | 5 | 0 | 4 |
For details and further investigation, click here
