| Full name: alsin Rho guanine nucleotide exchange factor ALS2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q33.1 | ||
| Entrez ID: 57679 | HGNC ID: HGNC:443 | Ensembl Gene: ENSG00000003393 | OMIM ID: 606352 |
| Drug and gene relationship at DGIdb | |||
ALS2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
Expression of ALS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALS2 | 57679 | 226291_at | 0.4707 | 0.2555 | |
| GSE26886 | ALS2 | 57679 | 226291_at | 0.6906 | 0.0479 | |
| GSE45670 | ALS2 | 57679 | 226291_at | 0.3426 | 0.1212 | |
| GSE53622 | ALS2 | 57679 | 33652 | 0.4030 | 0.0000 | |
| GSE53624 | ALS2 | 57679 | 33652 | 0.4873 | 0.0000 | |
| GSE63941 | ALS2 | 57679 | 226291_at | -0.9368 | 0.0544 | |
| GSE77861 | ALS2 | 57679 | 226291_at | 0.8745 | 0.0010 | |
| GSE97050 | ALS2 | 57679 | A_33_P3415345 | 0.1926 | 0.4601 | |
| SRP007169 | ALS2 | 57679 | RNAseq | 0.0283 | 0.9367 | |
| SRP008496 | ALS2 | 57679 | RNAseq | 0.5085 | 0.0710 | |
| SRP064894 | ALS2 | 57679 | RNAseq | 0.0820 | 0.6599 | |
| SRP133303 | ALS2 | 57679 | RNAseq | 0.2806 | 0.0230 | |
| SRP159526 | ALS2 | 57679 | RNAseq | 0.5929 | 0.0100 | |
| SRP193095 | ALS2 | 57679 | RNAseq | 0.2809 | 0.0120 | |
| SRP219564 | ALS2 | 57679 | RNAseq | 0.0622 | 0.8478 | |
| TCGA | ALS2 | 57679 | RNAseq | -0.0112 | 0.8309 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALS2 | 57679 | 6 | 4 | 20 | |
| GSE20123 | ALS2 | 57679 | 6 | 4 | 20 | |
| GSE43470 | ALS2 | 57679 | 1 | 1 | 41 | |
| GSE46452 | ALS2 | 57679 | 1 | 4 | 54 | |
| GSE47630 | ALS2 | 57679 | 4 | 5 | 31 | |
| GSE54993 | ALS2 | 57679 | 0 | 3 | 67 | |
| GSE54994 | ALS2 | 57679 | 10 | 8 | 35 | |
| GSE60625 | ALS2 | 57679 | 0 | 3 | 8 | |
| GSE74703 | ALS2 | 57679 | 1 | 1 | 34 | |
| GSE74704 | ALS2 | 57679 | 3 | 2 | 15 | |
| TCGA | ALS2 | 57679 | 21 | 11 | 64 |
Total number of gains: 53; Total number of losses: 46; Total Number of normals: 389.
Somatic mutations of ALS2:
Generating mutation plots.
Highly correlated genes for ALS2:
Showing top 20/976 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALS2 | STX16 | 0.847334 | 3 | 0 | 3 |
| ALS2 | SFR1 | 0.818825 | 3 | 0 | 3 |
| ALS2 | PRRC2C | 0.811925 | 3 | 0 | 3 |
| ALS2 | LINC00328 | 0.803969 | 3 | 0 | 3 |
| ALS2 | CCDC127 | 0.803585 | 3 | 0 | 3 |
| ALS2 | DHRSX | 0.77662 | 3 | 0 | 3 |
| ALS2 | RFTN1 | 0.769599 | 3 | 0 | 3 |
| ALS2 | UBQLN4 | 0.769137 | 3 | 0 | 3 |
| ALS2 | WDR37 | 0.762984 | 3 | 0 | 3 |
| ALS2 | AKR1B1 | 0.757448 | 4 | 0 | 4 |
| ALS2 | ANXA6 | 0.755968 | 3 | 0 | 3 |
| ALS2 | ATIC | 0.755222 | 4 | 0 | 4 |
| ALS2 | TAP1 | 0.754348 | 3 | 0 | 3 |
| ALS2 | PLEKHO2 | 0.739164 | 3 | 0 | 3 |
| ALS2 | HIRA | 0.738652 | 3 | 0 | 3 |
| ALS2 | SH2B2 | 0.737859 | 3 | 0 | 3 |
| ALS2 | TOMM40L | 0.737738 | 3 | 0 | 3 |
| ALS2 | CELF1 | 0.734694 | 4 | 0 | 4 |
| ALS2 | RBM17 | 0.733191 | 3 | 0 | 3 |
| ALS2 | PDE7A | 0.731637 | 5 | 0 | 5 |
For details and further investigation, click here
