| Full name: aldo-keto reductase family 1 member B | Alias Symbol: AR | ||
| Type: protein-coding gene | Cytoband: 7q33 | ||
| Entrez ID: 231 | HGNC ID: HGNC:381 | Ensembl Gene: ENSG00000085662 | OMIM ID: 103880 |
| Drug and gene relationship at DGIdb | |||
Expression of AKR1B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKR1B1 | 231 | 201272_at | 1.0111 | 0.1913 | |
| GSE20347 | AKR1B1 | 231 | 201272_at | 1.5812 | 0.0000 | |
| GSE23400 | AKR1B1 | 231 | 201272_at | 1.1129 | 0.0000 | |
| GSE26886 | AKR1B1 | 231 | 201272_at | 1.4941 | 0.0000 | |
| GSE29001 | AKR1B1 | 231 | 201272_at | 0.9747 | 0.0014 | |
| GSE38129 | AKR1B1 | 231 | 201272_at | 1.4822 | 0.0000 | |
| GSE45670 | AKR1B1 | 231 | 201272_at | 0.9983 | 0.0161 | |
| GSE53622 | AKR1B1 | 231 | 65390 | 0.5043 | 0.0053 | |
| GSE53624 | AKR1B1 | 231 | 65390 | 0.4370 | 0.0011 | |
| GSE63941 | AKR1B1 | 231 | 201272_at | -1.7479 | 0.1988 | |
| GSE77861 | AKR1B1 | 231 | 201272_at | 2.3989 | 0.0001 | |
| GSE97050 | AKR1B1 | 231 | A_23_P258190 | 0.9300 | 0.1057 | |
| SRP007169 | AKR1B1 | 231 | RNAseq | 1.9930 | 0.0000 | |
| SRP008496 | AKR1B1 | 231 | RNAseq | 2.1537 | 0.0000 | |
| SRP064894 | AKR1B1 | 231 | RNAseq | 1.4873 | 0.0000 | |
| SRP133303 | AKR1B1 | 231 | RNAseq | 1.1447 | 0.0000 | |
| SRP159526 | AKR1B1 | 231 | RNAseq | 2.3077 | 0.0000 | |
| SRP193095 | AKR1B1 | 231 | RNAseq | 1.7474 | 0.0000 | |
| SRP219564 | AKR1B1 | 231 | RNAseq | 0.8943 | 0.1416 | |
| TCGA | AKR1B1 | 231 | RNAseq | 0.2264 | 0.0374 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by AKR1B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKR1B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKR1B1 | 231 | 6 | 2 | 22 | |
| GSE20123 | AKR1B1 | 231 | 6 | 2 | 22 | |
| GSE43470 | AKR1B1 | 231 | 2 | 3 | 38 | |
| GSE46452 | AKR1B1 | 231 | 7 | 2 | 50 | |
| GSE47630 | AKR1B1 | 231 | 7 | 4 | 29 | |
| GSE54993 | AKR1B1 | 231 | 3 | 5 | 62 | |
| GSE54994 | AKR1B1 | 231 | 6 | 8 | 39 | |
| GSE60625 | AKR1B1 | 231 | 0 | 0 | 11 | |
| GSE74703 | AKR1B1 | 231 | 2 | 3 | 31 | |
| GSE74704 | AKR1B1 | 231 | 2 | 2 | 16 | |
| TCGA | AKR1B1 | 231 | 28 | 23 | 45 |
Total number of gains: 69; Total number of losses: 54; Total Number of normals: 365.
Somatic mutations of AKR1B1:
Generating mutation plots.
Highly correlated genes for AKR1B1:
Showing top 20/1667 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKR1B1 | PDPR | 0.814182 | 3 | 0 | 3 |
| AKR1B1 | CDCA2 | 0.774307 | 4 | 0 | 4 |
| AKR1B1 | ALS2 | 0.757448 | 4 | 0 | 4 |
| AKR1B1 | XPR1 | 0.757385 | 5 | 0 | 5 |
| AKR1B1 | TBX1 | 0.756049 | 4 | 0 | 4 |
| AKR1B1 | SLC37A3 | 0.746589 | 4 | 0 | 4 |
| AKR1B1 | SRGN | 0.742637 | 3 | 0 | 3 |
| AKR1B1 | HEY1 | 0.739843 | 9 | 0 | 9 |
| AKR1B1 | C18orf54 | 0.739389 | 4 | 0 | 3 |
| AKR1B1 | FHL3 | 0.73929 | 3 | 0 | 3 |
| AKR1B1 | CPT1C | 0.738676 | 3 | 0 | 3 |
| AKR1B1 | PLD3 | 0.735523 | 4 | 0 | 4 |
| AKR1B1 | WDR81 | 0.735345 | 4 | 0 | 4 |
| AKR1B1 | IDS | 0.734701 | 3 | 0 | 3 |
| AKR1B1 | PHLDB2 | 0.734629 | 5 | 0 | 5 |
| AKR1B1 | MSANTD3 | 0.730823 | 4 | 0 | 4 |
| AKR1B1 | RAB2B | 0.73052 | 3 | 0 | 3 |
| AKR1B1 | NONO | 0.730416 | 6 | 0 | 6 |
| AKR1B1 | SLC39A13 | 0.730018 | 3 | 0 | 3 |
| AKR1B1 | ELFN1 | 0.726096 | 3 | 0 | 3 |
For details and further investigation, click here
