| Full name: ALX homeobox 4 | Alias Symbol: FPP|PFM|KIAA1788 | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 60529 | HGNC ID: HGNC:450 | Ensembl Gene: ENSG00000052850 | OMIM ID: 605420 |
| Drug and gene relationship at DGIdb | |||
Expression of ALX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALX4 | 60529 | 208330_at | 0.0040 | 0.9920 | |
| GSE20347 | ALX4 | 60529 | 208330_at | 0.0363 | 0.6807 | |
| GSE23400 | ALX4 | 60529 | 208330_at | -0.1408 | 0.0000 | |
| GSE26886 | ALX4 | 60529 | 208330_at | 0.2584 | 0.0356 | |
| GSE29001 | ALX4 | 60529 | 208330_at | 0.0377 | 0.8115 | |
| GSE38129 | ALX4 | 60529 | 208330_at | -0.0808 | 0.3532 | |
| GSE45670 | ALX4 | 60529 | 208330_at | 0.0108 | 0.9216 | |
| GSE53622 | ALX4 | 60529 | 28379 | -0.0691 | 0.3460 | |
| GSE53624 | ALX4 | 60529 | 28379 | -0.4215 | 0.0000 | |
| GSE63941 | ALX4 | 60529 | 208330_at | 0.2460 | 0.0376 | |
| GSE77861 | ALX4 | 60529 | 208330_at | 0.0145 | 0.9245 | |
| SRP133303 | ALX4 | 60529 | RNAseq | 2.0679 | 0.0017 | |
| TCGA | ALX4 | 60529 | RNAseq | 3.5410 | 0.0002 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ALX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALX4 | 60529 | 2 | 8 | 20 | |
| GSE20123 | ALX4 | 60529 | 2 | 7 | 21 | |
| GSE43470 | ALX4 | 60529 | 2 | 4 | 37 | |
| GSE46452 | ALX4 | 60529 | 8 | 5 | 46 | |
| GSE47630 | ALX4 | 60529 | 3 | 9 | 28 | |
| GSE54993 | ALX4 | 60529 | 3 | 0 | 67 | |
| GSE54994 | ALX4 | 60529 | 3 | 9 | 41 | |
| GSE60625 | ALX4 | 60529 | 0 | 0 | 11 | |
| GSE74703 | ALX4 | 60529 | 2 | 2 | 32 | |
| GSE74704 | ALX4 | 60529 | 2 | 5 | 13 | |
| TCGA | ALX4 | 60529 | 15 | 20 | 61 |
Total number of gains: 42; Total number of losses: 69; Total Number of normals: 377.
Somatic mutations of ALX4:
Generating mutation plots.
Highly correlated genes for ALX4:
Showing top 20/981 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALX4 | KCTD19 | 0.735785 | 4 | 0 | 4 |
| ALX4 | SLC22A12 | 0.70937 | 4 | 0 | 4 |
| ALX4 | ZEB1-AS1 | 0.692715 | 3 | 0 | 3 |
| ALX4 | FAM222A-AS1 | 0.678477 | 3 | 0 | 3 |
| ALX4 | ZNF460 | 0.6778 | 4 | 0 | 3 |
| ALX4 | CHST4 | 0.670727 | 4 | 0 | 4 |
| ALX4 | OR1F1 | 0.669241 | 8 | 0 | 7 |
| ALX4 | GAD2 | 0.667616 | 5 | 0 | 5 |
| ALX4 | SLC22A7 | 0.665947 | 7 | 0 | 5 |
| ALX4 | KRTAP3-1 | 0.663606 | 3 | 0 | 3 |
| ALX4 | CLDN9 | 0.662871 | 8 | 0 | 7 |
| ALX4 | ARHGEF15 | 0.659228 | 4 | 0 | 4 |
| ALX4 | CHRM5 | 0.658831 | 6 | 0 | 6 |
| ALX4 | KCNV1 | 0.653361 | 3 | 0 | 3 |
| ALX4 | ADM2 | 0.653339 | 7 | 0 | 7 |
| ALX4 | SHISA8 | 0.650934 | 4 | 0 | 3 |
| ALX4 | NR2E3 | 0.648946 | 7 | 0 | 6 |
| ALX4 | ICAM1 | 0.648922 | 3 | 0 | 3 |
| ALX4 | PRG3 | 0.648701 | 5 | 0 | 5 |
| ALX4 | TSPAN10 | 0.647536 | 3 | 0 | 3 |
For details and further investigation, click here
