| Full name: intercellular adhesion molecule 1 | Alias Symbol: BB2|CD54 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 3383 | HGNC ID: HGNC:5344 | Ensembl Gene: ENSG00000090339 | OMIM ID: 147840 |
| Drug and gene relationship at DGIdb | |||
ICAM1 involved pathways:
Expression of ICAM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ICAM1 | 3383 | 202637_s_at | 0.3366 | 0.7140 | |
| GSE20347 | ICAM1 | 3383 | 202637_s_at | 0.5438 | 0.0015 | |
| GSE23400 | ICAM1 | 3383 | 202637_s_at | 0.4689 | 0.0001 | |
| GSE26886 | ICAM1 | 3383 | 215485_s_at | 0.2820 | 0.0105 | |
| GSE29001 | ICAM1 | 3383 | 202637_s_at | 0.9695 | 0.0020 | |
| GSE38129 | ICAM1 | 3383 | 202637_s_at | 0.3786 | 0.1802 | |
| GSE45670 | ICAM1 | 3383 | 202637_s_at | 0.5651 | 0.1394 | |
| GSE63941 | ICAM1 | 3383 | 202637_s_at | 0.4522 | 0.7357 | |
| GSE77861 | ICAM1 | 3383 | 215485_s_at | 0.0750 | 0.3650 | |
| GSE97050 | ICAM1 | 3383 | A_23_P153320 | 1.0617 | 0.0555 | |
| SRP007169 | ICAM1 | 3383 | RNAseq | 2.2266 | 0.0000 | |
| SRP008496 | ICAM1 | 3383 | RNAseq | 1.5319 | 0.0010 | |
| SRP064894 | ICAM1 | 3383 | RNAseq | 1.3825 | 0.0000 | |
| SRP133303 | ICAM1 | 3383 | RNAseq | 1.4939 | 0.0000 | |
| SRP159526 | ICAM1 | 3383 | RNAseq | 1.4518 | 0.0003 | |
| SRP193095 | ICAM1 | 3383 | RNAseq | 2.2873 | 0.0000 | |
| SRP219564 | ICAM1 | 3383 | RNAseq | 2.7090 | 0.0000 | |
| TCGA | ICAM1 | 3383 | RNAseq | 0.3914 | 0.0004 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by ICAM1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ICAM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ICAM1 | 3383 | 4 | 3 | 23 | |
| GSE20123 | ICAM1 | 3383 | 3 | 1 | 26 | |
| GSE43470 | ICAM1 | 3383 | 3 | 6 | 34 | |
| GSE46452 | ICAM1 | 3383 | 47 | 1 | 11 | |
| GSE47630 | ICAM1 | 3383 | 4 | 7 | 29 | |
| GSE54993 | ICAM1 | 3383 | 16 | 3 | 51 | |
| GSE54994 | ICAM1 | 3383 | 7 | 13 | 33 | |
| GSE60625 | ICAM1 | 3383 | 9 | 0 | 2 | |
| GSE74703 | ICAM1 | 3383 | 3 | 4 | 29 | |
| GSE74704 | ICAM1 | 3383 | 0 | 1 | 19 | |
| TCGA | ICAM1 | 3383 | 13 | 15 | 68 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of ICAM1:
Generating mutation plots.
Highly correlated genes for ICAM1:
Showing top 20/833 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ICAM1 | LYAR | 0.771794 | 3 | 0 | 3 |
| ICAM1 | FBLIM1 | 0.742212 | 3 | 0 | 3 |
| ICAM1 | RAVER1 | 0.742006 | 3 | 0 | 3 |
| ICAM1 | TMEM176A | 0.732711 | 5 | 0 | 5 |
| ICAM1 | CTRB2 | 0.728794 | 3 | 0 | 3 |
| ICAM1 | EGFLAM | 0.724049 | 4 | 0 | 3 |
| ICAM1 | GTF2E1 | 0.714191 | 3 | 0 | 3 |
| ICAM1 | POLR2J | 0.712689 | 3 | 0 | 3 |
| ICAM1 | TAF2 | 0.701133 | 3 | 0 | 3 |
| ICAM1 | NEIL2 | 0.700933 | 3 | 0 | 3 |
| ICAM1 | PPP1R35 | 0.698874 | 3 | 0 | 3 |
| ICAM1 | TPM3 | 0.698709 | 3 | 0 | 3 |
| ICAM1 | DCTN6 | 0.69806 | 3 | 0 | 3 |
| ICAM1 | PROX1 | 0.696267 | 4 | 0 | 4 |
| ICAM1 | CXCL11 | 0.691958 | 7 | 0 | 7 |
| ICAM1 | C3AR1 | 0.691554 | 5 | 0 | 4 |
| ICAM1 | FAU | 0.690034 | 3 | 0 | 3 |
| ICAM1 | TMEM176B | 0.688725 | 5 | 0 | 5 |
| ICAM1 | NAB2 | 0.68806 | 3 | 0 | 3 |
| ICAM1 | GLB1L | 0.686401 | 3 | 0 | 3 |
For details and further investigation, click here
