MAGI3

 

Full name: membrane associated guanylate kinase, WW and PDZ domain containing 3 Alias Symbol: MAGI-3
Type: protein-coding gene Cytoband: 1p13.2
Entrez ID: 260425 HGNC ID: HGNC:29647 Ensembl Gene: ENSG00000081026 OMIM ID: 615943
Drug and gene relationship at DGIdb

 

MAGI3 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04530Tight junction

 

Expression of MAGI3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAGI3 260425 226770_at -0.8578 0.2008
GSE26886 MAGI3 260425 226770_at -1.7043 0.0000
GSE45670 MAGI3 260425 226770_at -0.8224 0.0004
GSE53622 MAGI3 260425 92570 -1.2141 0.0000
GSE53624 MAGI3 260425 35220 -1.2885 0.0000
GSE63941 MAGI3 260425 226770_at 0.6519 0.3438
GSE77861 MAGI3 260425 226770_at -1.1185 0.0011
GSE97050 MAGI3 260425 A_33_P3369520 -0.3378 0.2765
SRP007169 MAGI3 260425 RNAseq -1.2995 0.0054
SRP008496 MAGI3 260425 RNAseq -1.5293 0.0000
SRP064894 MAGI3 260425 RNAseq -2.0372 0.0000
SRP133303 MAGI3 260425 RNAseq -0.8541 0.0000
SRP159526 MAGI3 260425 RNAseq -2.0055 0.0000
SRP193095 MAGI3 260425 RNAseq -1.6892 0.0000
SRP219564 MAGI3 260425 RNAseq -0.9634 0.1390
TCGA MAGI3 260425 RNAseq -0.4381 0.0000

Upregulated datasets: 0; Downregulated datasets: 9.  

 

Survival by MAGI3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAGI3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAGI3 260425 0 9 21
GSE20123 MAGI3 260425 0 10 20
GSE43470 MAGI3 260425 0 8 35
GSE46452 MAGI3 260425 2 1 56
GSE47630 MAGI3 260425 9 5 26
GSE54993 MAGI3 260425 0 1 69
GSE54994 MAGI3 260425 7 3 43
GSE60625 MAGI3 260425 0 0 11
GSE74703 MAGI3 260425 0 7 29
GSE74704 MAGI3 260425 0 6 14
TCGA MAGI3 260425 11 29 56

Total number of gains: 29; Total number of losses: 79; Total Number of normals: 380.  

 

Somatic mutations of MAGI3:

 

Generating mutation plots.

 

Highly correlated genes for MAGI3:

 

Showing top 20/1371 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAGI3UBL30.826063707
MAGI3PHACTR40.82226606
MAGI3PADI10.821471404
MAGI3FAM3D0.806876707
MAGI3KAT2B0.805157606
MAGI3SOCS60.802072404
MAGI3C18orf250.797832606
MAGI3SCP20.796624606
MAGI3CAB39L0.795865606
MAGI3C5orf66-AS10.794714606
MAGI3CCNG20.792841606
MAGI3CHP10.791641606
MAGI3ABHD50.786743606
MAGI3ANXA110.78552606
MAGI3FCHO20.7852606
MAGI3CTTNBP2NL0.783232606
MAGI3VSIG20.782238707
MAGI3MPP70.781965606
MAGI3KRT780.781921707
MAGI3MKRN20.781636404

For details and further investigation, click here