| Full name: methylenetetrahydrofolate reductase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 4524 | HGNC ID: HGNC:7436 | Ensembl Gene: ENSG00000177000 | OMIM ID: 607093 |
| Drug and gene relationship at DGIdb | |||
Expression of MTHFR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTHFR | 4524 | 226929_at | 0.2052 | 0.4019 | |
| GSE20347 | MTHFR | 4524 | 206800_at | -0.1618 | 0.0428 | |
| GSE23400 | MTHFR | 4524 | 206800_at | -0.0978 | 0.0035 | |
| GSE26886 | MTHFR | 4524 | 226929_at | -1.1998 | 0.0000 | |
| GSE29001 | MTHFR | 4524 | 206800_at | -0.3631 | 0.0081 | |
| GSE38129 | MTHFR | 4524 | 217070_at | -0.0378 | 0.6501 | |
| GSE45670 | MTHFR | 4524 | 226929_at | 0.0726 | 0.6783 | |
| GSE53622 | MTHFR | 4524 | 149188 | -0.0356 | 0.6035 | |
| GSE53624 | MTHFR | 4524 | 149188 | -0.0000 | 0.9998 | |
| GSE63941 | MTHFR | 4524 | 226929_at | 0.1720 | 0.7597 | |
| GSE77861 | MTHFR | 4524 | 217070_at | 0.0427 | 0.7756 | |
| GSE97050 | MTHFR | 4524 | A_23_P404045 | -0.2245 | 0.4359 | |
| SRP007169 | MTHFR | 4524 | RNAseq | -0.9819 | 0.0362 | |
| SRP008496 | MTHFR | 4524 | RNAseq | -0.9888 | 0.0012 | |
| SRP064894 | MTHFR | 4524 | RNAseq | -0.2792 | 0.1939 | |
| SRP133303 | MTHFR | 4524 | RNAseq | -0.4550 | 0.0036 | |
| SRP159526 | MTHFR | 4524 | RNAseq | -0.7349 | 0.0020 | |
| SRP193095 | MTHFR | 4524 | RNAseq | -0.1099 | 0.5137 | |
| SRP219564 | MTHFR | 4524 | RNAseq | -0.2957 | 0.3116 | |
| TCGA | MTHFR | 4524 | RNAseq | -0.4165 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MTHFR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MTHFR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTHFR | 4524 | 0 | 5 | 25 | |
| GSE20123 | MTHFR | 4524 | 0 | 4 | 26 | |
| GSE43470 | MTHFR | 4524 | 4 | 6 | 33 | |
| GSE46452 | MTHFR | 4524 | 7 | 1 | 51 | |
| GSE47630 | MTHFR | 4524 | 8 | 4 | 28 | |
| GSE54993 | MTHFR | 4524 | 3 | 1 | 66 | |
| GSE54994 | MTHFR | 4524 | 11 | 4 | 38 | |
| GSE60625 | MTHFR | 4524 | 0 | 0 | 11 | |
| GSE74703 | MTHFR | 4524 | 3 | 4 | 29 | |
| GSE74704 | MTHFR | 4524 | 0 | 0 | 20 | |
| TCGA | MTHFR | 4524 | 10 | 22 | 64 |
Total number of gains: 46; Total number of losses: 51; Total Number of normals: 391.
Somatic mutations of MTHFR:
Generating mutation plots.
Highly correlated genes for MTHFR:
Showing top 20/396 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTHFR | TMEM80 | 0.795572 | 3 | 0 | 3 |
| MTHFR | KCTD15 | 0.773538 | 3 | 0 | 3 |
| MTHFR | SGSH | 0.769823 | 3 | 0 | 3 |
| MTHFR | PDLIM2 | 0.752852 | 3 | 0 | 3 |
| MTHFR | FAM174A | 0.744202 | 3 | 0 | 3 |
| MTHFR | PLEKHM1 | 0.74301 | 4 | 0 | 3 |
| MTHFR | DVL1 | 0.740495 | 3 | 0 | 3 |
| MTHFR | AMOTL2 | 0.731378 | 3 | 0 | 3 |
| MTHFR | NLRX1 | 0.723074 | 4 | 0 | 3 |
| MTHFR | PPP1R16A | 0.718985 | 3 | 0 | 3 |
| MTHFR | ZNF607 | 0.717528 | 3 | 0 | 3 |
| MTHFR | CPEB2 | 0.716037 | 3 | 0 | 3 |
| MTHFR | GORASP2 | 0.712623 | 3 | 0 | 3 |
| MTHFR | XRRA1 | 0.710984 | 3 | 0 | 3 |
| MTHFR | TSHR | 0.708808 | 3 | 0 | 3 |
| MTHFR | AKAP17A | 0.704083 | 3 | 0 | 3 |
| MTHFR | MMAA | 0.702751 | 3 | 0 | 3 |
| MTHFR | TMEM167A | 0.701507 | 3 | 0 | 3 |
| MTHFR | FN3K | 0.700231 | 5 | 0 | 4 |
| MTHFR | RRP9 | 0.696813 | 3 | 0 | 3 |
For details and further investigation, click here
