| Full name: coiled-coil-helix-coiled-coil-helix domain containing 1 | Alias Symbol: FLJ25854 | ||
| Type: protein-coding gene | Cytoband: 10q22.2 | ||
| Entrez ID: 118487 | HGNC ID: HGNC:23518 | Ensembl Gene: ENSG00000172586 | OMIM ID: 608842 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CHCHD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHCHD1 | 118487 | 226896_at | -0.0975 | 0.8833 | |
| GSE26886 | CHCHD1 | 118487 | 226896_at | -0.5532 | 0.0012 | |
| GSE45670 | CHCHD1 | 118487 | 226896_at | -0.0940 | 0.4344 | |
| GSE53622 | CHCHD1 | 118487 | 27391 | -0.4622 | 0.0000 | |
| GSE53624 | CHCHD1 | 118487 | 27391 | -0.1397 | 0.0100 | |
| GSE63941 | CHCHD1 | 118487 | 226896_at | 0.3196 | 0.3690 | |
| GSE77861 | CHCHD1 | 118487 | 226896_at | -0.5093 | 0.1064 | |
| GSE97050 | CHCHD1 | 118487 | A_23_P371613 | -0.1590 | 0.6411 | |
| SRP007169 | CHCHD1 | 118487 | RNAseq | -1.2121 | 0.0022 | |
| SRP008496 | CHCHD1 | 118487 | RNAseq | -1.0450 | 0.0000 | |
| SRP064894 | CHCHD1 | 118487 | RNAseq | -0.3455 | 0.1894 | |
| SRP133303 | CHCHD1 | 118487 | RNAseq | -0.0991 | 0.4436 | |
| SRP159526 | CHCHD1 | 118487 | RNAseq | -0.5444 | 0.0380 | |
| SRP193095 | CHCHD1 | 118487 | RNAseq | -0.8157 | 0.0000 | |
| SRP219564 | CHCHD1 | 118487 | RNAseq | -0.3823 | 0.1754 | |
| TCGA | CHCHD1 | 118487 | RNAseq | 0.0496 | 0.4111 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CHCHD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHCHD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHCHD1 | 118487 | 3 | 4 | 23 | |
| GSE20123 | CHCHD1 | 118487 | 3 | 3 | 24 | |
| GSE43470 | CHCHD1 | 118487 | 1 | 8 | 34 | |
| GSE46452 | CHCHD1 | 118487 | 0 | 11 | 48 | |
| GSE47630 | CHCHD1 | 118487 | 2 | 14 | 24 | |
| GSE54993 | CHCHD1 | 118487 | 7 | 0 | 63 | |
| GSE54994 | CHCHD1 | 118487 | 2 | 10 | 41 | |
| GSE60625 | CHCHD1 | 118487 | 0 | 0 | 11 | |
| GSE74703 | CHCHD1 | 118487 | 1 | 5 | 30 | |
| GSE74704 | CHCHD1 | 118487 | 1 | 1 | 18 | |
| TCGA | CHCHD1 | 118487 | 11 | 23 | 62 |
Total number of gains: 31; Total number of losses: 79; Total Number of normals: 378.
Somatic mutations of CHCHD1:
Generating mutation plots.
Highly correlated genes for CHCHD1:
Showing top 20/966 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHCHD1 | RABGGTA | 0.805152 | 3 | 0 | 3 |
| CHCHD1 | C2CD2 | 0.802389 | 3 | 0 | 3 |
| CHCHD1 | NANS | 0.784756 | 4 | 0 | 4 |
| CHCHD1 | COMTD1 | 0.779711 | 4 | 0 | 4 |
| CHCHD1 | MRPS18A | 0.77261 | 3 | 0 | 3 |
| CHCHD1 | DVL1 | 0.771596 | 3 | 0 | 3 |
| CHCHD1 | EPS15L1 | 0.768863 | 4 | 0 | 4 |
| CHCHD1 | PFDN5 | 0.767034 | 3 | 0 | 3 |
| CHCHD1 | FBXW7 | 0.756017 | 3 | 0 | 3 |
| CHCHD1 | WDR47 | 0.754187 | 3 | 0 | 3 |
| CHCHD1 | ANAPC5 | 0.753683 | 3 | 0 | 3 |
| CHCHD1 | WDR77 | 0.747772 | 4 | 0 | 3 |
| CHCHD1 | TMEM120A | 0.746645 | 4 | 0 | 4 |
| CHCHD1 | TP53RK | 0.742839 | 3 | 0 | 3 |
| CHCHD1 | TPCN1 | 0.740991 | 3 | 0 | 3 |
| CHCHD1 | SAR1A | 0.738186 | 3 | 0 | 3 |
| CHCHD1 | EZR | 0.734344 | 3 | 0 | 3 |
| CHCHD1 | HECTD3 | 0.733827 | 4 | 0 | 4 |
| CHCHD1 | STK40 | 0.733025 | 4 | 0 | 4 |
| CHCHD1 | WSB2 | 0.731915 | 3 | 0 | 3 |
For details and further investigation, click here
