| Full name: anaphase promoting complex subunit 7 | Alias Symbol: APC7 | ||
| Type: protein-coding gene | Cytoband: 12q24.11 | ||
| Entrez ID: 51434 | HGNC ID: HGNC:17380 | Ensembl Gene: ENSG00000196510 | OMIM ID: 606949 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ANAPC7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation | |
| hsa05166 | HTLV-I infection |
Expression of ANAPC7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANAPC7 | 51434 | 225554_s_at | 0.0075 | 0.9891 | |
| GSE26886 | ANAPC7 | 51434 | 225554_s_at | -0.0479 | 0.8432 | |
| GSE45670 | ANAPC7 | 51434 | 225554_s_at | 0.1257 | 0.3846 | |
| GSE53622 | ANAPC7 | 51434 | 85535 | -0.0834 | 0.2839 | |
| GSE53624 | ANAPC7 | 51434 | 85535 | -0.3128 | 0.0000 | |
| GSE63941 | ANAPC7 | 51434 | 225554_s_at | 0.2275 | 0.4013 | |
| GSE77861 | ANAPC7 | 51434 | 225554_s_at | -0.0098 | 0.9538 | |
| GSE97050 | ANAPC7 | 51434 | A_23_P44643 | 0.0740 | 0.7166 | |
| SRP007169 | ANAPC7 | 51434 | RNAseq | -0.0889 | 0.7851 | |
| SRP008496 | ANAPC7 | 51434 | RNAseq | -0.2578 | 0.1110 | |
| SRP064894 | ANAPC7 | 51434 | RNAseq | -0.2153 | 0.1222 | |
| SRP133303 | ANAPC7 | 51434 | RNAseq | -0.2976 | 0.0525 | |
| SRP159526 | ANAPC7 | 51434 | RNAseq | -0.1135 | 0.4672 | |
| SRP193095 | ANAPC7 | 51434 | RNAseq | -0.2209 | 0.1133 | |
| SRP219564 | ANAPC7 | 51434 | RNAseq | -0.3297 | 0.3036 | |
| TCGA | ANAPC7 | 51434 | RNAseq | 0.2143 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ANAPC7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANAPC7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANAPC7 | 51434 | 5 | 3 | 22 | |
| GSE20123 | ANAPC7 | 51434 | 5 | 3 | 22 | |
| GSE43470 | ANAPC7 | 51434 | 2 | 1 | 40 | |
| GSE46452 | ANAPC7 | 51434 | 9 | 1 | 49 | |
| GSE47630 | ANAPC7 | 51434 | 9 | 3 | 28 | |
| GSE54993 | ANAPC7 | 51434 | 0 | 5 | 65 | |
| GSE54994 | ANAPC7 | 51434 | 4 | 3 | 46 | |
| GSE60625 | ANAPC7 | 51434 | 0 | 0 | 11 | |
| GSE74703 | ANAPC7 | 51434 | 2 | 0 | 34 | |
| GSE74704 | ANAPC7 | 51434 | 2 | 2 | 16 | |
| TCGA | ANAPC7 | 51434 | 22 | 10 | 64 |
Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.
Somatic mutations of ANAPC7:
Generating mutation plots.
Highly correlated genes for ANAPC7:
Showing top 20/178 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANAPC7 | MKKS | 0.719756 | 3 | 0 | 3 |
| ANAPC7 | TRUB2 | 0.709559 | 3 | 0 | 3 |
| ANAPC7 | FGGY | 0.7076 | 4 | 0 | 3 |
| ANAPC7 | PSMD9 | 0.702014 | 3 | 0 | 3 |
| ANAPC7 | AP4E1 | 0.694941 | 3 | 0 | 3 |
| ANAPC7 | LCMT1 | 0.68943 | 3 | 0 | 3 |
| ANAPC7 | MED8 | 0.686267 | 3 | 0 | 3 |
| ANAPC7 | SMARCAL1 | 0.682445 | 3 | 0 | 3 |
| ANAPC7 | GTF3C4 | 0.678899 | 3 | 0 | 3 |
| ANAPC7 | MYSM1 | 0.675033 | 3 | 0 | 3 |
| ANAPC7 | ALG6 | 0.674803 | 3 | 0 | 3 |
| ANAPC7 | SMURF1 | 0.671146 | 3 | 0 | 3 |
| ANAPC7 | ABHD12 | 0.668164 | 3 | 0 | 3 |
| ANAPC7 | RAB35 | 0.661462 | 3 | 0 | 3 |
| ANAPC7 | RBCK1 | 0.659448 | 3 | 0 | 3 |
| ANAPC7 | MAP2K6 | 0.654735 | 3 | 0 | 3 |
| ANAPC7 | RMND1 | 0.654512 | 3 | 0 | 3 |
| ANAPC7 | GSPT1 | 0.654306 | 3 | 0 | 3 |
| ANAPC7 | ATG2B | 0.654131 | 3 | 0 | 3 |
| ANAPC7 | ZNF200 | 0.653636 | 3 | 0 | 3 |
For details and further investigation, click here
