| Full name: mediator complex subunit 8 | Alias Symbol: MGC17544|MGC19641|ARC32 | ||
| Type: protein-coding gene | Cytoband: 1p34.2 | ||
| Entrez ID: 112950 | HGNC ID: HGNC:19971 | Ensembl Gene: ENSG00000159479 | OMIM ID: 607956 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MED8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MED8 | 112950 | 213696_s_at | -0.2460 | 0.7075 | |
| GSE20347 | MED8 | 112950 | 213127_s_at | -0.6524 | 0.0000 | |
| GSE23400 | MED8 | 112950 | 213127_s_at | -0.2148 | 0.0000 | |
| GSE26886 | MED8 | 112950 | 213696_s_at | -0.4684 | 0.0238 | |
| GSE29001 | MED8 | 112950 | 213127_s_at | -0.6139 | 0.0213 | |
| GSE38129 | MED8 | 112950 | 213127_s_at | -0.4955 | 0.0000 | |
| GSE45670 | MED8 | 112950 | 213696_s_at | 0.1740 | 0.3625 | |
| GSE53622 | MED8 | 112950 | 139587 | -0.2062 | 0.0118 | |
| GSE53624 | MED8 | 112950 | 139587 | -0.2008 | 0.0051 | |
| GSE63941 | MED8 | 112950 | 213696_s_at | 0.2199 | 0.6437 | |
| GSE77861 | MED8 | 112950 | 213696_s_at | -0.4260 | 0.1499 | |
| GSE97050 | MED8 | 112950 | A_24_P233915 | -0.0363 | 0.9043 | |
| SRP007169 | MED8 | 112950 | RNAseq | -0.9845 | 0.0058 | |
| SRP008496 | MED8 | 112950 | RNAseq | -0.8214 | 0.0000 | |
| SRP064894 | MED8 | 112950 | RNAseq | -0.0532 | 0.7562 | |
| SRP133303 | MED8 | 112950 | RNAseq | -0.1610 | 0.4137 | |
| SRP159526 | MED8 | 112950 | RNAseq | 0.0900 | 0.8530 | |
| SRP193095 | MED8 | 112950 | RNAseq | -0.5626 | 0.0000 | |
| SRP219564 | MED8 | 112950 | RNAseq | 0.1218 | 0.7987 | |
| TCGA | MED8 | 112950 | RNAseq | 0.0484 | 0.3928 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MED8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MED8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MED8 | 112950 | 4 | 3 | 23 | |
| GSE20123 | MED8 | 112950 | 4 | 2 | 24 | |
| GSE43470 | MED8 | 112950 | 7 | 2 | 34 | |
| GSE46452 | MED8 | 112950 | 3 | 1 | 55 | |
| GSE47630 | MED8 | 112950 | 9 | 2 | 29 | |
| GSE54993 | MED8 | 112950 | 0 | 2 | 68 | |
| GSE54994 | MED8 | 112950 | 13 | 2 | 38 | |
| GSE60625 | MED8 | 112950 | 0 | 0 | 11 | |
| GSE74703 | MED8 | 112950 | 6 | 1 | 29 | |
| GSE74704 | MED8 | 112950 | 2 | 0 | 18 | |
| TCGA | MED8 | 112950 | 13 | 16 | 67 |
Total number of gains: 61; Total number of losses: 31; Total Number of normals: 396.
Somatic mutations of MED8:
Generating mutation plots.
Highly correlated genes for MED8:
Showing top 20/975 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MED8 | TRAPPC6B | 0.804822 | 3 | 0 | 3 |
| MED8 | VTI1B | 0.801026 | 3 | 0 | 3 |
| MED8 | PSMD7 | 0.793974 | 3 | 0 | 3 |
| MED8 | CDYL | 0.767742 | 3 | 0 | 3 |
| MED8 | ZDHHC5 | 0.764052 | 4 | 0 | 4 |
| MED8 | UGP2 | 0.761965 | 4 | 0 | 4 |
| MED8 | TTC39B | 0.756944 | 4 | 0 | 4 |
| MED8 | PA2G4 | 0.73845 | 3 | 0 | 3 |
| MED8 | PEPD | 0.71671 | 3 | 0 | 3 |
| MED8 | BTBD7 | 0.71597 | 4 | 0 | 4 |
| MED8 | ELOVL1 | 0.700399 | 4 | 0 | 4 |
| MED8 | CDC37L1 | 0.695285 | 4 | 0 | 4 |
| MED8 | WIPF2 | 0.694551 | 4 | 0 | 3 |
| MED8 | GSKIP | 0.6932 | 5 | 0 | 4 |
| MED8 | COPZ1 | 0.692581 | 4 | 0 | 3 |
| MED8 | GNL2 | 0.688405 | 3 | 0 | 3 |
| MED8 | TET2 | 0.687907 | 4 | 0 | 3 |
| MED8 | SNAPC3 | 0.686695 | 3 | 0 | 3 |
| MED8 | ANAPC7 | 0.686267 | 3 | 0 | 3 |
| MED8 | AKAP9 | 0.682162 | 3 | 0 | 3 |
For details and further investigation, click here
