| Full name: RANBP2-type and C3HC4-type zinc finger containing 1 | Alias Symbol: RBCK2|XAP4|RNF54|ZRANB4|UBCE7IP3|HOIL1 | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 10616 | HGNC ID: HGNC:15864 | Ensembl Gene: ENSG00000125826 | OMIM ID: 610924 |
| Drug and gene relationship at DGIdb | |||
Expression of RBCK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RBCK1 | 10616 | 221827_at | 0.3561 | 0.4342 | |
| GSE20347 | RBCK1 | 10616 | 221827_at | 0.2783 | 0.1623 | |
| GSE23400 | RBCK1 | 10616 | 221827_at | 0.4670 | 0.0000 | |
| GSE26886 | RBCK1 | 10616 | 221827_at | 0.7877 | 0.0079 | |
| GSE29001 | RBCK1 | 10616 | 221827_at | 0.5108 | 0.0381 | |
| GSE38129 | RBCK1 | 10616 | 221827_at | 0.5670 | 0.0006 | |
| GSE45670 | RBCK1 | 10616 | 221827_at | 0.5418 | 0.0304 | |
| GSE53622 | RBCK1 | 10616 | 50396 | 0.6660 | 0.0000 | |
| GSE53624 | RBCK1 | 10616 | 50396 | 0.6755 | 0.0000 | |
| GSE63941 | RBCK1 | 10616 | 221827_at | 0.7639 | 0.3386 | |
| GSE77861 | RBCK1 | 10616 | 221827_at | 0.2713 | 0.4039 | |
| GSE97050 | RBCK1 | 10616 | A_23_P166051 | 0.3829 | 0.3518 | |
| SRP007169 | RBCK1 | 10616 | RNAseq | -1.0724 | 0.0135 | |
| SRP008496 | RBCK1 | 10616 | RNAseq | -0.7676 | 0.0068 | |
| SRP064894 | RBCK1 | 10616 | RNAseq | 0.6753 | 0.0032 | |
| SRP133303 | RBCK1 | 10616 | RNAseq | 0.4782 | 0.0004 | |
| SRP159526 | RBCK1 | 10616 | RNAseq | 0.3903 | 0.1076 | |
| SRP193095 | RBCK1 | 10616 | RNAseq | 0.2725 | 0.0180 | |
| SRP219564 | RBCK1 | 10616 | RNAseq | 0.4955 | 0.0796 | |
| TCGA | RBCK1 | 10616 | RNAseq | 0.0596 | 0.2206 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RBCK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RBCK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RBCK1 | 10616 | 12 | 4 | 14 | |
| GSE20123 | RBCK1 | 10616 | 13 | 4 | 13 | |
| GSE43470 | RBCK1 | 10616 | 11 | 1 | 31 | |
| GSE46452 | RBCK1 | 10616 | 26 | 1 | 32 | |
| GSE47630 | RBCK1 | 10616 | 19 | 4 | 17 | |
| GSE54993 | RBCK1 | 10616 | 2 | 15 | 53 | |
| GSE54994 | RBCK1 | 10616 | 24 | 2 | 27 | |
| GSE60625 | RBCK1 | 10616 | 0 | 0 | 11 | |
| GSE74703 | RBCK1 | 10616 | 10 | 1 | 25 | |
| GSE74704 | RBCK1 | 10616 | 8 | 2 | 10 | |
| TCGA | RBCK1 | 10616 | 41 | 11 | 44 |
Total number of gains: 166; Total number of losses: 45; Total Number of normals: 277.
Somatic mutations of RBCK1:
Generating mutation plots.
Highly correlated genes for RBCK1:
Showing top 20/778 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RBCK1 | MCTP1 | 0.798771 | 3 | 0 | 3 |
| RBCK1 | TRAF7 | 0.788879 | 4 | 0 | 4 |
| RBCK1 | TPMT | 0.772445 | 3 | 0 | 3 |
| RBCK1 | RBM33 | 0.737187 | 3 | 0 | 3 |
| RBCK1 | PLXNB2 | 0.725903 | 3 | 0 | 3 |
| RBCK1 | RNASEH2B | 0.71966 | 3 | 0 | 3 |
| RBCK1 | ROMO1 | 0.718139 | 3 | 0 | 3 |
| RBCK1 | NOP56 | 0.715661 | 3 | 0 | 3 |
| RBCK1 | MVP | 0.703678 | 5 | 0 | 4 |
| RBCK1 | ITGB8 | 0.696233 | 3 | 0 | 3 |
| RBCK1 | POLG | 0.695496 | 3 | 0 | 3 |
| RBCK1 | PACS1 | 0.692873 | 3 | 0 | 3 |
| RBCK1 | UTP23 | 0.690738 | 3 | 0 | 3 |
| RBCK1 | TP53I13 | 0.679347 | 4 | 0 | 4 |
| RBCK1 | MRPL55 | 0.677425 | 4 | 0 | 3 |
| RBCK1 | PET117 | 0.672138 | 5 | 0 | 4 |
| RBCK1 | GNB5 | 0.670719 | 3 | 0 | 3 |
| RBCK1 | BIRC3 | 0.669543 | 3 | 0 | 3 |
| RBCK1 | VAPB | 0.666878 | 6 | 0 | 5 |
| RBCK1 | PYCR2 | 0.665188 | 3 | 0 | 3 |
For details and further investigation, click here
