| Full name: ALG6 alpha-1,3-glucosyltransferase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 29929 | HGNC ID: HGNC:23157 | Ensembl Gene: ENSG00000088035 | OMIM ID: 604566 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ALG6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALG6 | 29929 | 219649_at | 0.3386 | 0.5923 | |
| GSE20347 | ALG6 | 29929 | 219649_at | 0.3408 | 0.0702 | |
| GSE23400 | ALG6 | 29929 | 219649_at | 0.3596 | 0.0000 | |
| GSE26886 | ALG6 | 29929 | 219649_at | -1.0192 | 0.0013 | |
| GSE29001 | ALG6 | 29929 | 219649_at | 0.4526 | 0.0483 | |
| GSE38129 | ALG6 | 29929 | 219649_at | 0.4756 | 0.0131 | |
| GSE45670 | ALG6 | 29929 | 219649_at | 0.4223 | 0.0010 | |
| GSE53622 | ALG6 | 29929 | 6729 | 0.1313 | 0.0610 | |
| GSE53624 | ALG6 | 29929 | 6729 | 0.2358 | 0.0004 | |
| GSE63941 | ALG6 | 29929 | 219649_at | 0.4798 | 0.2636 | |
| GSE77861 | ALG6 | 29929 | 219649_at | -0.2723 | 0.5168 | |
| GSE97050 | ALG6 | 29929 | A_23_P35168 | 0.1043 | 0.8315 | |
| SRP007169 | ALG6 | 29929 | RNAseq | 0.1874 | 0.6885 | |
| SRP008496 | ALG6 | 29929 | RNAseq | 0.0438 | 0.8720 | |
| SRP064894 | ALG6 | 29929 | RNAseq | 0.4866 | 0.0178 | |
| SRP133303 | ALG6 | 29929 | RNAseq | 0.4103 | 0.0662 | |
| SRP159526 | ALG6 | 29929 | RNAseq | -0.3340 | 0.2758 | |
| SRP193095 | ALG6 | 29929 | RNAseq | -0.2452 | 0.0143 | |
| SRP219564 | ALG6 | 29929 | RNAseq | 0.3674 | 0.4116 | |
| TCGA | ALG6 | 29929 | RNAseq | 0.2184 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ALG6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALG6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALG6 | 29929 | 3 | 6 | 21 | |
| GSE20123 | ALG6 | 29929 | 3 | 5 | 22 | |
| GSE43470 | ALG6 | 29929 | 5 | 4 | 34 | |
| GSE46452 | ALG6 | 29929 | 1 | 1 | 57 | |
| GSE47630 | ALG6 | 29929 | 8 | 5 | 27 | |
| GSE54993 | ALG6 | 29929 | 0 | 0 | 70 | |
| GSE54994 | ALG6 | 29929 | 6 | 4 | 43 | |
| GSE60625 | ALG6 | 29929 | 0 | 0 | 11 | |
| GSE74703 | ALG6 | 29929 | 4 | 3 | 29 | |
| GSE74704 | ALG6 | 29929 | 2 | 2 | 16 | |
| TCGA | ALG6 | 29929 | 10 | 20 | 66 |
Total number of gains: 42; Total number of losses: 50; Total Number of normals: 396.
Somatic mutations of ALG6:
Generating mutation plots.
Highly correlated genes for ALG6:
Showing top 20/711 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALG6 | BROX | 0.846318 | 3 | 0 | 3 |
| ALG6 | BLOC1S2 | 0.809257 | 3 | 0 | 3 |
| ALG6 | PITHD1 | 0.799132 | 3 | 0 | 3 |
| ALG6 | TET2 | 0.79228 | 3 | 0 | 3 |
| ALG6 | THRAP3 | 0.786365 | 3 | 0 | 3 |
| ALG6 | AGPAT3 | 0.764405 | 3 | 0 | 3 |
| ALG6 | SIAE | 0.759391 | 3 | 0 | 3 |
| ALG6 | MRI1 | 0.747382 | 3 | 0 | 3 |
| ALG6 | SCAF4 | 0.746121 | 3 | 0 | 3 |
| ALG6 | LMBRD2 | 0.7448 | 3 | 0 | 3 |
| ALG6 | C2CD2 | 0.743231 | 4 | 0 | 3 |
| ALG6 | MKRN1 | 0.741657 | 3 | 0 | 3 |
| ALG6 | TMEM219 | 0.739457 | 3 | 0 | 3 |
| ALG6 | USP16 | 0.736961 | 3 | 0 | 3 |
| ALG6 | TAB3 | 0.731355 | 3 | 0 | 3 |
| ALG6 | WDFY1 | 0.727422 | 3 | 0 | 3 |
| ALG6 | ALG10 | 0.724815 | 4 | 0 | 3 |
| ALG6 | RPS24 | 0.723323 | 3 | 0 | 3 |
| ALG6 | ZNF257 | 0.71284 | 3 | 0 | 3 |
| ALG6 | TATDN2 | 0.707473 | 4 | 0 | 3 |
For details and further investigation, click here
