| Full name: oxysterol binding protein 2 | Alias Symbol: KIAA1664|ORP-4|ORP4 | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 23762 | HGNC ID: HGNC:8504 | Ensembl Gene: ENSG00000184792 | OMIM ID: 606729 |
| Drug and gene relationship at DGIdb | |||
Expression of OSBP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OSBP2 | 23762 | 223432_at | 0.1431 | 0.7178 | |
| GSE20347 | OSBP2 | 23762 | 221237_s_at | -0.1244 | 0.1093 | |
| GSE23400 | OSBP2 | 23762 | 221237_s_at | -0.1267 | 0.0006 | |
| GSE26886 | OSBP2 | 23762 | 221237_s_at | 0.0586 | 0.6843 | |
| GSE29001 | OSBP2 | 23762 | 221237_s_at | -0.2289 | 0.1997 | |
| GSE38129 | OSBP2 | 23762 | 221237_s_at | -0.2682 | 0.0009 | |
| GSE45670 | OSBP2 | 23762 | 223432_at | 0.1788 | 0.0941 | |
| GSE53622 | OSBP2 | 23762 | 23196 | 0.2635 | 0.0305 | |
| GSE53624 | OSBP2 | 23762 | 23196 | 0.0006 | 0.9958 | |
| GSE63941 | OSBP2 | 23762 | 221237_s_at | 0.4870 | 0.1127 | |
| GSE77861 | OSBP2 | 23762 | 223432_at | 0.1808 | 0.1764 | |
| GSE97050 | OSBP2 | 23762 | A_23_P321935 | 0.4292 | 0.3820 | |
| SRP007169 | OSBP2 | 23762 | RNAseq | -1.9134 | 0.0064 | |
| SRP064894 | OSBP2 | 23762 | RNAseq | -0.5634 | 0.0497 | |
| SRP133303 | OSBP2 | 23762 | RNAseq | 0.1619 | 0.6531 | |
| SRP159526 | OSBP2 | 23762 | RNAseq | 0.3346 | 0.3021 | |
| SRP193095 | OSBP2 | 23762 | RNAseq | 0.3602 | 0.0814 | |
| SRP219564 | OSBP2 | 23762 | RNAseq | 1.2870 | 0.1382 | |
| TCGA | OSBP2 | 23762 | RNAseq | 0.0809 | 0.6429 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by OSBP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OSBP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OSBP2 | 23762 | 4 | 5 | 21 | |
| GSE20123 | OSBP2 | 23762 | 4 | 4 | 22 | |
| GSE43470 | OSBP2 | 23762 | 4 | 5 | 34 | |
| GSE46452 | OSBP2 | 23762 | 31 | 1 | 27 | |
| GSE47630 | OSBP2 | 23762 | 8 | 5 | 27 | |
| GSE54993 | OSBP2 | 23762 | 3 | 6 | 61 | |
| GSE54994 | OSBP2 | 23762 | 11 | 8 | 34 | |
| GSE60625 | OSBP2 | 23762 | 5 | 0 | 6 | |
| GSE74703 | OSBP2 | 23762 | 4 | 5 | 27 | |
| GSE74704 | OSBP2 | 23762 | 1 | 1 | 18 | |
| TCGA | OSBP2 | 23762 | 28 | 15 | 53 |
Total number of gains: 103; Total number of losses: 55; Total Number of normals: 330.
Somatic mutations of OSBP2:
Generating mutation plots.
Highly correlated genes for OSBP2:
Showing top 20/316 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OSBP2 | ANGPTL3 | 0.715269 | 3 | 0 | 3 |
| OSBP2 | SCLY | 0.706866 | 3 | 0 | 3 |
| OSBP2 | SLC38A3 | 0.694584 | 4 | 0 | 4 |
| OSBP2 | PFKFB2 | 0.69339 | 3 | 0 | 3 |
| OSBP2 | IGH | 0.686223 | 3 | 0 | 3 |
| OSBP2 | IHH | 0.671986 | 3 | 0 | 3 |
| OSBP2 | SNX8 | 0.66154 | 3 | 0 | 3 |
| OSBP2 | PRKACA | 0.652532 | 3 | 0 | 3 |
| OSBP2 | MAPRE3 | 0.644047 | 4 | 0 | 3 |
| OSBP2 | LINC01137 | 0.643587 | 4 | 0 | 3 |
| OSBP2 | ABHD4 | 0.643529 | 3 | 0 | 3 |
| OSBP2 | PRDM11 | 0.640061 | 3 | 0 | 3 |
| OSBP2 | IGHMBP2 | 0.636998 | 4 | 0 | 3 |
| OSBP2 | BIRC7 | 0.636897 | 3 | 0 | 3 |
| OSBP2 | PLIN1 | 0.63149 | 3 | 0 | 3 |
| OSBP2 | CCDC88B | 0.629801 | 6 | 0 | 4 |
| OSBP2 | MAPK11 | 0.628765 | 4 | 0 | 3 |
| OSBP2 | ATN1 | 0.621108 | 3 | 0 | 3 |
| OSBP2 | CLSTN3 | 0.620756 | 3 | 0 | 3 |
| OSBP2 | DUX1 | 0.620615 | 5 | 0 | 5 |
For details and further investigation, click here
