| Full name: carbonic anhydrase 1 | Alias Symbol: Car1 | ||
| Type: protein-coding gene | Cytoband: 8q21.2 | ||
| Entrez ID: 759 | HGNC ID: HGNC:1368 | Ensembl Gene: ENSG00000133742 | OMIM ID: 114800 |
| Drug and gene relationship at DGIdb | |||
Expression of CA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CA1 | 759 | 205950_s_at | -0.0571 | 0.8771 | |
| GSE20347 | CA1 | 759 | 205950_s_at | 0.0078 | 0.9383 | |
| GSE23400 | CA1 | 759 | 205950_s_at | -0.0650 | 0.0552 | |
| GSE26886 | CA1 | 759 | 205950_s_at | -0.2650 | 0.1116 | |
| GSE29001 | CA1 | 759 | 205949_at | -0.2570 | 0.0702 | |
| GSE38129 | CA1 | 759 | 205950_s_at | -0.1414 | 0.0210 | |
| GSE45670 | CA1 | 759 | 205950_s_at | 0.1752 | 0.0578 | |
| GSE53622 | CA1 | 759 | 43582 | -0.5435 | 0.0064 | |
| GSE53624 | CA1 | 759 | 43582 | -0.0888 | 0.3564 | |
| GSE63941 | CA1 | 759 | 205950_s_at | 0.2914 | 0.0451 | |
| GSE77861 | CA1 | 759 | 205950_s_at | -0.0854 | 0.3746 | |
| SRP133303 | CA1 | 759 | RNAseq | -1.5092 | 0.0000 | |
| SRP193095 | CA1 | 759 | RNAseq | -0.6589 | 0.0189 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CA1 | 759 | 13 | 2 | 15 | |
| GSE20123 | CA1 | 759 | 15 | 2 | 13 | |
| GSE43470 | CA1 | 759 | 18 | 1 | 24 | |
| GSE46452 | CA1 | 759 | 21 | 0 | 38 | |
| GSE47630 | CA1 | 759 | 23 | 0 | 17 | |
| GSE54993 | CA1 | 759 | 0 | 19 | 51 | |
| GSE54994 | CA1 | 759 | 33 | 1 | 19 | |
| GSE60625 | CA1 | 759 | 0 | 4 | 7 | |
| GSE74703 | CA1 | 759 | 15 | 1 | 20 | |
| GSE74704 | CA1 | 759 | 10 | 0 | 10 | |
| TCGA | CA1 | 759 | 54 | 2 | 40 |
Total number of gains: 202; Total number of losses: 32; Total Number of normals: 254.
Somatic mutations of CA1:
Generating mutation plots.
Highly correlated genes for CA1:
Showing top 20/1047 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CA1 | ADM2 | 0.700851 | 5 | 0 | 5 |
| CA1 | IFNA17 | 0.695571 | 6 | 0 | 6 |
| CA1 | MPV17L | 0.692436 | 4 | 0 | 4 |
| CA1 | FAM124B | 0.690226 | 4 | 0 | 4 |
| CA1 | EPOR | 0.688356 | 8 | 0 | 7 |
| CA1 | KCNJ10 | 0.686847 | 4 | 0 | 4 |
| CA1 | HSPB6 | 0.684203 | 5 | 0 | 5 |
| CA1 | MUC5AC | 0.683984 | 6 | 0 | 6 |
| CA1 | LGI2 | 0.681111 | 4 | 0 | 3 |
| CA1 | CCDC7 | 0.679207 | 5 | 0 | 5 |
| CA1 | PDE3B | 0.679172 | 4 | 0 | 4 |
| CA1 | OLFM1 | 0.67515 | 3 | 0 | 3 |
| CA1 | WNK2 | 0.673626 | 4 | 0 | 3 |
| CA1 | MAP3K19 | 0.67271 | 8 | 0 | 8 |
| CA1 | ITGA10 | 0.672493 | 6 | 0 | 5 |
| CA1 | CIITA | 0.671442 | 6 | 0 | 6 |
| CA1 | CCL16 | 0.670523 | 4 | 0 | 4 |
| CA1 | TCTN2 | 0.670459 | 5 | 0 | 5 |
| CA1 | CHRNA2 | 0.669125 | 8 | 0 | 7 |
| CA1 | FSCN3 | 0.667897 | 5 | 0 | 5 |
For details and further investigation, click here
