| Full name: interferon gamma inducible protein 16 | Alias Symbol: IFNGIP1|PYHIN2 | ||
| Type: protein-coding gene | Cytoband: 1q23.1 | ||
| Entrez ID: 3428 | HGNC ID: HGNC:5395 | Ensembl Gene: ENSG00000163565 | OMIM ID: 147586 |
| Drug and gene relationship at DGIdb | |||
Expression of IFI16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IFI16 | 3428 | 208966_x_at | 0.8638 | 0.0653 | |
| GSE20347 | IFI16 | 3428 | 208966_x_at | 0.8509 | 0.0001 | |
| GSE23400 | IFI16 | 3428 | 208966_x_at | 1.1080 | 0.0000 | |
| GSE26886 | IFI16 | 3428 | 208966_x_at | 0.9065 | 0.0147 | |
| GSE29001 | IFI16 | 3428 | 208966_x_at | 1.0578 | 0.0006 | |
| GSE38129 | IFI16 | 3428 | 208966_x_at | 0.9400 | 0.0000 | |
| GSE45670 | IFI16 | 3428 | 208966_x_at | 0.8908 | 0.0000 | |
| GSE53622 | IFI16 | 3428 | 123351 | 0.9893 | 0.0000 | |
| GSE53624 | IFI16 | 3428 | 123351 | 1.1173 | 0.0000 | |
| GSE63941 | IFI16 | 3428 | 206332_s_at | -0.3887 | 0.8195 | |
| GSE77861 | IFI16 | 3428 | 208966_x_at | 0.7215 | 0.0501 | |
| GSE97050 | IFI16 | 3428 | A_23_P160025 | 1.0334 | 0.1065 | |
| SRP007169 | IFI16 | 3428 | RNAseq | 1.1246 | 0.0153 | |
| SRP008496 | IFI16 | 3428 | RNAseq | 0.9031 | 0.0153 | |
| SRP064894 | IFI16 | 3428 | RNAseq | 0.7411 | 0.0012 | |
| SRP133303 | IFI16 | 3428 | RNAseq | 0.7160 | 0.0001 | |
| SRP159526 | IFI16 | 3428 | RNAseq | 0.3878 | 0.3588 | |
| SRP193095 | IFI16 | 3428 | RNAseq | 1.0338 | 0.0000 | |
| SRP219564 | IFI16 | 3428 | RNAseq | 0.5008 | 0.3300 | |
| TCGA | IFI16 | 3428 | RNAseq | 0.5653 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by IFI16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IFI16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IFI16 | 3428 | 9 | 0 | 21 | |
| GSE20123 | IFI16 | 3428 | 9 | 0 | 21 | |
| GSE43470 | IFI16 | 3428 | 7 | 2 | 34 | |
| GSE46452 | IFI16 | 3428 | 2 | 1 | 56 | |
| GSE47630 | IFI16 | 3428 | 14 | 0 | 26 | |
| GSE54993 | IFI16 | 3428 | 0 | 5 | 65 | |
| GSE54994 | IFI16 | 3428 | 16 | 0 | 37 | |
| GSE60625 | IFI16 | 3428 | 0 | 0 | 11 | |
| GSE74703 | IFI16 | 3428 | 7 | 2 | 27 | |
| GSE74704 | IFI16 | 3428 | 3 | 0 | 17 | |
| TCGA | IFI16 | 3428 | 42 | 4 | 50 |
Total number of gains: 109; Total number of losses: 14; Total Number of normals: 365.
Somatic mutations of IFI16:
Generating mutation plots.
Highly correlated genes for IFI16:
Showing top 20/1776 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IFI16 | FAM89A | 0.77795 | 3 | 0 | 3 |
| IFI16 | PSPC1 | 0.767487 | 4 | 0 | 4 |
| IFI16 | ANKFY1 | 0.743765 | 3 | 0 | 3 |
| IFI16 | PARP12 | 0.730944 | 11 | 0 | 11 |
| IFI16 | UHMK1 | 0.730533 | 7 | 0 | 6 |
| IFI16 | RNMT | 0.729858 | 4 | 0 | 4 |
| IFI16 | NUF2 | 0.729494 | 7 | 0 | 6 |
| IFI16 | CDH3 | 0.72546 | 9 | 0 | 9 |
| IFI16 | ZBTB9 | 0.724642 | 5 | 0 | 5 |
| IFI16 | CDC42SE2 | 0.724492 | 4 | 0 | 4 |
| IFI16 | CEP55 | 0.723244 | 10 | 0 | 10 |
| IFI16 | HEATR1 | 0.721739 | 12 | 0 | 11 |
| IFI16 | CDC37 | 0.721598 | 3 | 0 | 3 |
| IFI16 | TMTC4 | 0.72135 | 3 | 0 | 3 |
| IFI16 | ATAD2 | 0.71991 | 10 | 0 | 10 |
| IFI16 | PLAU | 0.716765 | 11 | 0 | 11 |
| IFI16 | CPSF6 | 0.713518 | 10 | 0 | 10 |
| IFI16 | C12orf49 | 0.71323 | 5 | 0 | 5 |
| IFI16 | TOP2A | 0.712386 | 10 | 0 | 10 |
| IFI16 | ASPM | 0.71086 | 11 | 0 | 10 |
For details and further investigation, click here
