SP110

 

Full name: SP110 nuclear body protein Alias Symbol: 
Type: protein-coding gene Cytoband: 2q37.1
Entrez ID: 3431 HGNC ID: HGNC:5401 Ensembl Gene: ENSG00000135899 OMIM ID: 604457
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of SP110:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SP110 3431 208012_x_at 0.3406 0.4702
GSE20347 SP110 3431 208012_x_at 0.0354 0.8930
GSE23400 SP110 3431 208012_x_at 0.3174 0.0009
GSE26886 SP110 3431 208012_x_at 0.8643 0.0159
GSE29001 SP110 3431 208012_x_at 0.7624 0.0287
GSE38129 SP110 3431 208012_x_at -0.0063 0.9759
GSE45670 SP110 3431 208012_x_at 1.0259 0.0006
GSE53622 SP110 3431 113138 0.4919 0.0000
GSE53624 SP110 3431 113138 0.6367 0.0000
GSE63941 SP110 3431 208012_x_at -0.6885 0.4456
GSE77861 SP110 3431 208012_x_at 0.0110 0.9703
GSE97050 SP110 3431 A_23_P120002 0.5908 0.2316
SRP007169 SP110 3431 RNAseq 1.0914 0.0689
SRP008496 SP110 3431 RNAseq 0.5777 0.1678
SRP064894 SP110 3431 RNAseq 1.2256 0.0000
SRP133303 SP110 3431 RNAseq 0.4892 0.0112
SRP159526 SP110 3431 RNAseq -0.1412 0.7626
SRP193095 SP110 3431 RNAseq 0.7501 0.0001
SRP219564 SP110 3431 RNAseq 1.3354 0.0063
TCGA SP110 3431 RNAseq 0.2258 0.0138

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by SP110 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SP110:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SP110 3431 1 13 16
GSE20123 SP110 3431 1 13 16
GSE43470 SP110 3431 2 8 33
GSE46452 SP110 3431 0 5 54
GSE47630 SP110 3431 4 5 31
GSE54993 SP110 3431 2 2 66
GSE54994 SP110 3431 6 11 36
GSE60625 SP110 3431 0 3 8
GSE74703 SP110 3431 2 6 28
GSE74704 SP110 3431 1 6 13
TCGA SP110 3431 13 27 56

Total number of gains: 32; Total number of losses: 99; Total Number of normals: 357.  

 

Somatic mutations of SP110:

 

Generating mutation plots.

 

Highly correlated genes for SP110:

 

Showing top 20/513 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SP110DDX60L0.787942605
SP110AGFG10.777987303
SP110STAMBP0.764056303
SP110DDX600.7584912011
SP110STAT10.74812312011
SP110SP1000.7395813011
SP110ANKFY10.729189404
SP110GBP10.72689711010
SP110PARP90.726235807
SP110GTPBP80.712567404
SP110XAF10.71204713012
SP110EME10.710805303
SP110CMPK20.709447806
SP110MNT0.707636303
SP110IFIH10.7069581109
SP110PSME20.702921303
SP110FARS20.698884303
SP110IFI440.69885512012
SP110EPSTI10.69836805
SP110IFI60.69800912011

For details and further investigation, click here