| Full name: adaptor related protein complex 3 subunit beta 1 | Alias Symbol: ADTB3A|HPS2 | ||
| Type: protein-coding gene | Cytoband: 5q14.1 | ||
| Entrez ID: 8546 | HGNC ID: HGNC:566 | Ensembl Gene: ENSG00000132842 | OMIM ID: 603401 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of AP3B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AP3B1 | 8546 | 203142_s_at | -0.3969 | 0.5494 | |
| GSE20347 | AP3B1 | 8546 | 203142_s_at | -0.7493 | 0.0000 | |
| GSE23400 | AP3B1 | 8546 | 203142_s_at | -0.2105 | 0.0000 | |
| GSE26886 | AP3B1 | 8546 | 203142_s_at | -1.1165 | 0.0001 | |
| GSE29001 | AP3B1 | 8546 | 203142_s_at | -0.4843 | 0.0333 | |
| GSE38129 | AP3B1 | 8546 | 203142_s_at | -0.4362 | 0.0014 | |
| GSE45670 | AP3B1 | 8546 | 203142_s_at | -0.1243 | 0.3204 | |
| GSE53622 | AP3B1 | 8546 | 7559 | -0.5975 | 0.0000 | |
| GSE53624 | AP3B1 | 8546 | 7559 | -0.6312 | 0.0000 | |
| GSE63941 | AP3B1 | 8546 | 203142_s_at | -0.0399 | 0.9249 | |
| GSE77861 | AP3B1 | 8546 | 203142_s_at | -0.4545 | 0.0886 | |
| GSE97050 | AP3B1 | 8546 | A_23_P136635 | -0.1420 | 0.5599 | |
| SRP007169 | AP3B1 | 8546 | RNAseq | -0.5140 | 0.1426 | |
| SRP008496 | AP3B1 | 8546 | RNAseq | -0.5177 | 0.0164 | |
| SRP064894 | AP3B1 | 8546 | RNAseq | -0.3715 | 0.0350 | |
| SRP133303 | AP3B1 | 8546 | RNAseq | -0.1437 | 0.3777 | |
| SRP159526 | AP3B1 | 8546 | RNAseq | -0.6061 | 0.1276 | |
| SRP193095 | AP3B1 | 8546 | RNAseq | -0.5850 | 0.0000 | |
| SRP219564 | AP3B1 | 8546 | RNAseq | -0.6043 | 0.1100 | |
| TCGA | AP3B1 | 8546 | RNAseq | -0.0921 | 0.0435 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AP3B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AP3B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AP3B1 | 8546 | 1 | 13 | 16 | |
| GSE20123 | AP3B1 | 8546 | 1 | 13 | 16 | |
| GSE43470 | AP3B1 | 8546 | 1 | 13 | 29 | |
| GSE46452 | AP3B1 | 8546 | 0 | 28 | 31 | |
| GSE47630 | AP3B1 | 8546 | 1 | 19 | 20 | |
| GSE54993 | AP3B1 | 8546 | 8 | 1 | 61 | |
| GSE54994 | AP3B1 | 8546 | 1 | 19 | 33 | |
| GSE60625 | AP3B1 | 8546 | 0 | 0 | 11 | |
| GSE74703 | AP3B1 | 8546 | 1 | 9 | 26 | |
| GSE74704 | AP3B1 | 8546 | 1 | 6 | 13 | |
| TCGA | AP3B1 | 8546 | 5 | 50 | 41 |
Total number of gains: 20; Total number of losses: 171; Total Number of normals: 297.
Somatic mutations of AP3B1:
Generating mutation plots.
Highly correlated genes for AP3B1:
Showing top 20/1495 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AP3B1 | SIAE | 0.76151 | 5 | 0 | 5 |
| AP3B1 | GPR108 | 0.753581 | 3 | 0 | 3 |
| AP3B1 | ZCCHC9 | 0.753133 | 7 | 0 | 6 |
| AP3B1 | HERPUD1 | 0.749721 | 3 | 0 | 3 |
| AP3B1 | WDR77 | 0.74767 | 3 | 0 | 3 |
| AP3B1 | CCNYL1 | 0.739829 | 5 | 0 | 5 |
| AP3B1 | ITGA2 | 0.738495 | 3 | 0 | 3 |
| AP3B1 | CCDC7 | 0.719904 | 3 | 0 | 3 |
| AP3B1 | CA13 | 0.708231 | 3 | 0 | 3 |
| AP3B1 | FAM174A | 0.70764 | 8 | 0 | 8 |
| AP3B1 | ALKBH7 | 0.706669 | 4 | 0 | 4 |
| AP3B1 | TMEM219 | 0.706378 | 4 | 0 | 4 |
| AP3B1 | DHRS4L2 | 0.704685 | 3 | 0 | 3 |
| AP3B1 | UBE2E1 | 0.702399 | 9 | 0 | 8 |
| AP3B1 | RPS9 | 0.701019 | 4 | 0 | 4 |
| AP3B1 | CGRRF1 | 0.700607 | 3 | 0 | 3 |
| AP3B1 | ARPC1A | 0.700136 | 4 | 0 | 3 |
| AP3B1 | SPRYD4 | 0.699776 | 4 | 0 | 3 |
| AP3B1 | NIPSNAP3A | 0.696778 | 6 | 0 | 6 |
| AP3B1 | ZNF57 | 0.693939 | 4 | 0 | 4 |
For details and further investigation, click here
